TransCode Therapeutics Inc. announced the submission of an Investigational New Drug $(IND)$ application amendment to the U.S. Food and Drug Administration (FDA) for a planned Phase 2a clinical trial of its lead therapeutic candidate, TTX-MC138. The trial, focused on colorectal cancer patients with positive markers for circulating tumor DNA, will be conducted in collaboration with Quantum Leap Healthcare Collaborative within the PRE-I-SPY program. The Phase 2a trial is expected to enroll up to 45 patients and will be led by Dr. Paula Pohlmann of MD Anderson Cancer Center.
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