Crescent Biopharma Doses First Patient in ASCEND Phase 1/2 Trial of CR-001 for Advanced Solid Tumors

Reuters

Feb 18

Crescent Biopharma Doses First Patient in ASCEND Phase 1/2 Trial of CR-001 for Advanced Solid Tumors

Crescent Biopharma Inc. announced that the first patient has been dosed in ASCEND, a global open-label Phase 1/2 trial (NCT07335497) evaluating CR-001, an investigational PD-1 x VEGF bispecific antibody, in advanced solid tumors including non-small cell lung cancer and gastrointestinal and gynecological cancers. The study plans to enroll up to 290 patients across dose-escalation, backfill and dose-optimization cohorts in the U.S., Europe and Asia Pacific, with primary endpoints focused on safety and tolerability and secondary endpoints including pharmacokinetics/pharmacodynamics, recommended Phase 2 dose, and preliminary antitumor activity. Results have not yet been presented; the company expects to report proof-of-concept data in the first quarter of 2027.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Crescent Biopharma Inc. published the original content used to generate this news brief via GlobeNewswire (Ref. ID: GNW9656499-en) on February 18, 2026, and is solely responsible for the information contained therein.

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