Bristol Myers Squibb announced positive top-line results from an ongoing ex-U.S. Phase 2 registrational study (NCT05664737) evaluating Reblozyl (luspatercept-aamt) versus placebo for anemia in adults with alpha-thalassemia. The non-transfusion-dependent cohort met its primary endpoint of increased hemoglobin levels, and the transfusion-dependent cohort met its primary endpoint of reduced red blood cell transfusion burden; key secondary endpoints were also met, with safety consistent with the known profile of Reblozyl. The company said the data will be presented at an upcoming medical congress.
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