The most-talked-about stocks in the Reddit subforum Wallstreetbets were mostly lower hours before Monday's opening bell.

Nvidia (NVDA) was up 0.2% in premarket hours, following a 1% increase from the previous session.

Novo Nordisk (NVO) fell by 15.3% in pre-bell activity, after closing Friday with a 2.1% decline. The company said its weight-loss treatment CagriSema failed to achieve the primary endpoint of demonstrating that it wasn't inferior to Eli Lilly's (LLY) tirzepatide in a late-stage Redefine 4 study.

Strategy (MSTR) declined by 2% premarket, reversing a 1.2% increase from the previous session.

Robinhood Markets (HOOD) was 1.5% lower pre-bell, after a 0.6% increase from Friday's session.

Antero Midstream (AM) was down 1.4% pre-bell, swinging from a 2.5% increase at Friday's close.

Tesla (TSLA) declined by 0.8% in premarket activity, following a slight increase from the previous session.

Microsoft (MSFT) was 0.3% lower premarket, after a 0.3% decline at Friday's close.

Netflix (NFLX) fell by 0.2% in pre-bell hours, swinging from a 2.2% increase from Friday's session.