Skye Bioscience Inc. released a corporate presentation outlining its obesity and metabolic disease pipeline, highlighting nimacimab, a peripherally restricted CB1-inhibiting antibody being evaluated in combination with semaglutide. The presentation summarizes Phase 2a CBeyond data showing 13 percent weight loss at 26 weeks for the combination versus semaglutide alone, and interim extension data indicating 22.3 percent total weight loss at 52 weeks with no plateau observed. It also reports reduced post-treatment weight regain in off-therapy follow-up for the combination versus semaglutide alone, along with a tolerability profile that did not show additive gastrointestinal burden or neuropsychiatric adverse events in the combination arm. You can access the full presentation through the link below.
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