BCL2(B细胞淋巴瘤2)是抗凋亡蛋白,在多种血液肿瘤中高表达,BCL2抑制剂特异性结合并抑制BCL2蛋白,恢复癌细胞的凋亡程序,让肿瘤细胞自然死亡。索托克拉是一款差异化的BCL2抑制剂,旨在阻断可帮助肿瘤细胞存活的BCL2蛋白,类属BH3类似物,可模拟自然细胞死亡信号。其设计旨在具有比维奈克拉更高的效力和选择性,半衰期较短且无药物蓄积。截至2026年2 月,已针对不同适应症和不同联合治疗入组了2...
Source LinkBCL2(B细胞淋巴瘤2)是抗凋亡蛋白,在多种血液肿瘤中高表达,BCL2抑制剂特异性结合并抑制BCL2蛋白,恢复癌细胞的凋亡程序,让肿瘤细胞自然死亡。索托克拉是一款差异化的BCL2抑制剂,旨在阻断可帮助肿瘤细胞存活的BCL2蛋白,类属BH3类似物,可模拟自然细胞死亡信号。其设计旨在具有比维奈克拉更高的效力和选择性,半衰期较短且无药物蓄积。截至2026年2 月,已针对不同适应症和不同联合治疗入组了2...
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