新京报讯 据“北京昌平”微信公众号消息,未来科学城生命谷企业诺诚健华近日宣布,中国首款、全球第二款进入临床的VAV1分子胶降解剂ICP-538完成首例受试者给药。ICP-538是诺诚健华自主研发的新型口服高效、高选择性靶向VAV1的特异性分子胶降解剂,VAV1是T细胞和B细胞受体下游的关键蛋白。ICP-538通过选择性介导CRBN E3泛素连接酶与VAV1蛋白形成三元复合物,剂量依赖性地诱导...
Source Link新京报讯 据“北京昌平”微信公众号消息,未来科学城生命谷企业诺诚健华近日宣布,中国首款、全球第二款进入临床的VAV1分子胶降解剂ICP-538完成首例受试者给药。ICP-538是诺诚健华自主研发的新型口服高效、高选择性靶向VAV1的特异性分子胶降解剂,VAV1是T细胞和B细胞受体下游的关键蛋白。ICP-538通过选择性介导CRBN E3泛素连接酶与VAV1蛋白形成三元复合物,剂量依赖性地诱导...
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