Inovio reports pDFVIII DNA therapy corrects bleeding in hemophilia A mice

Reuters

Mar 24

Inovio reports pDFVIII DNA therapy corrects bleeding in hemophilia A mice

Inovio reported preclinical results for a plasmid DNA medicine program designed to support long-term factor VIII replacement in hemophilia A, positioning it as a non-viral approach that could differentiate from existing gene therapy strategies.
The company said its delivery platform has shown durability in prior Phase 1 work, with in vivo production of encoded proteins persisting for at least 72 weeks.
Inovio stated the platform could support redosing and has not shown a host immune response against encoded proteins in that earlier clinical study, which may be relevant to competitive positioning in chronic treatment settings.

Disclaimer: This news brief was created by Public Technologies (PUBT) using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Inovio Pharmaceuticals Inc. published the original content used to generate this news brief on March 23, 2026, and is solely responsible for the information contained therein.

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