宜明昂科-B(01541):IMM0306治疗复发性╱难治性滤泡性淋巴瘤的III期临床试验完成首例患者给药

智通财经
Mar 31

智通财经APP讯,宜明昂科-B(01541)发布公告,IMM0306联合来那度胺治疗复发性╱难治性滤泡性淋巴瘤的III期临床试验顺利完成首例患者给药。

由本集团独立研发的IMM0306是一种靶向分化簇47 (CD47)及分化簇20 (CD20)的双特异性分子,是全球首个进入临床阶段的CD47和CD20双靶向双特异性分子。 IMM0306透过抑制CD47-SIRPα相互作用来阻断“别吃我”讯号,增强Fc-FcɣRIIa和 Fc-FcɣRIIIa相互作用来激活巨噬细胞和NK细胞,并优先结合CD20而非CD47,以有效消除恶性B细胞,同时将毒性降至最低,从而可改善治疗效果。

截至本公告日期,本集团拥有IMM0306的全球知识产权及商业化权利。

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