Vertex Pharmaceuticals Ends Study of Cystic Fibrosis Drug Over Tolerability Issues

Dow Jones

4 hours ago

By Elias Schisgall

Vertex Pharmaceuticals ended a Phase 1/2 study of an inhaled cystic fibrosis treatment developed jointly with Moderna after the study showed "persistent tolerability issues" with the drug.

The pharmaceutical company said Monday that ending the study of the drug, VX-522, "precludes assessment of efficacy and full safety and prevents further development of the VX-522 program."

The news came as the company logged a higher first-quarter profit and rising revenue, boosted in large part by demand for its cystic fibrosis treatments.

Shares fell 0.8% to $426.58 in after-hours trading. The stock closed up 1.4% at $429.85, down 5.2% this year.

Write to Elias Schisgall at elias.schisgall@wsj.com

(END) Dow Jones Newswires

May 04, 2026 18:59 ET (22:59 GMT)

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The stock closed up 1.4% at $429.85, down 5.2% this year. \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  Write to Elias Schisgall at elias.schisgall@wsj.com \n</p>\n<pre style=\"white-space: pre\">\n \n</pre>\n<p>\n  (END) Dow Jones Newswires\n</p>\n<p>\n  May 04, 2026 18:59 ET (22:59 GMT)\n</p>\n<p>\n  Copyright (c) 2026 Dow Jones &amp; Company, Inc.\n</p>\n</font>\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"LU1035775433.USD","symbol_name":"AB SICAV I - AMERICAN GROWTH PORTFOLIO \"AD\" (USD) INC","start_time":0,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","article_id":"2633962173","we_media_id":"106","thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2633962173","pubTimestamp":1777935540,"columns":[],"sourceInfo":null,"weMediaInfo":{"media_name":"Dow Jones","introduction":"Dow Jones publishes the world’s most trusted business news and financial information in a variety of media.","home_visible":0,"id":"106","head_image":"https://static.tigerbbs.com/150f88aa4d182df19190059f4a365e99"},"summary":"Vertex Pharmaceuticals ended a Phase 1/2 study of an inhaled cystic fibrosis treatment developed jointly with Moderna after the study showed \"persistent tolerability issues\" with the drug.The pharmaceutical company said Monday that ending the study of the drug, VX-522, \"precludes assessment of efficacy and full safety and prevents further development of the VX-522 program.\". 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The stock closed up 1.4% at $429.85, down 5.2% this year. \n\n\n \n\n\n  Write to Elias Schisgall at elias.schisgall@wsj.com \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  May 04, 2026 18:59 ET (22:59 GMT)\n\n\n  Copyright (c) 2026 Dow Jones & Company, Inc.","kind":"highlight","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"","news_rank":0,"isVideo":false,"video":null,"symbols":[],"gpt_button":0,"need_auth":true,"need_login_tip":false,"code":"91000000","status":"200"}}}