药捷安康-B(02617)在自然杂志子刊发表核心产品替恩戈替尼单药及联合阿替利珠单抗治疗晚期实体瘤的探索性临床结果

智通财经

May 17

智通财经APP讯，药捷安康-B(02617)发布公告，在Nature Communications(IF=15.7)发表核心产品替恩戈替尼单药及联合阿替利珠单抗治疗晚期实体瘤的探索性临床结果。

替恩戈替尼是一种激酶谱选择性多激酶抑制剂，可靶向成纤维细胞生长因子受体1-3(FGFR1-3)、 Janus激酶1/2(JAK1/2)、血管内皮生长因子受体(VEGFRs) 以及极光激酶A/B(Aurora A/B)。本项中国开展的Ib/II期临床试验(试验编号： NCT05253053)评估了替恩戈替尼单药治疗(A组，53例晚期实体瘤患者)及联合阿替利珠单抗治疗(B组，31例晚期胆道系统肿瘤患者)的疗效。

替恩戈替尼单药治疗A组的客观缓解率(ORR)达到为16.7%，联合阿替利珠单抗用药B组的客观缓解率为22.6%，均展现出抗肿瘤活性。在预设探索性亚组分析中，胆管癌患者疗效显著，A组(n=13)客观缓解率达到30.8%;B组( n=28)客观缓解率达到25.0%。对于既往经FGFR抑制剂治疗后进展、携带FGFR2融合突变的胆管癌患者，替恩戈替尼单药治疗客观缓解率达66.7%。在既往接受过免疫检查点抑制剂治疗的20例胆管癌患者中，联合方案客观缓解率为20.0%，疾病控制率达75.0%。上述研究结果支持进一步推进替恩戈替尼单药及联合免疫疗法的临床开发。

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