康诺亚-B(02162.HK)：CMG901(AZD0901)全球III期临床试验CLARITY-Gastric01取得积极顶线结果

智通财经

Jul 28

【康诺亚-B(02162.HK)：CMG901(AZD0901)全球III期临床试验CLARITY-Gastric01取得积极顶线结果】智通财经APP讯，康诺亚-B(02162.HK)发布公告，有关集团与AstraZeneca AB (AstraZeneca，一家全球生物制药公司)合作的CMG901(亦称为sonesitatug vedotin，AZD0901)最新临床进展。CLARITY-Gastric01全球III期临床试验公布的积极顶线结果显示，与研究者选择的治疗方案相比，CMG901(sonesitatug vedotin，AZD0901)在二线及后线 Claudin 18.2(CLDN18.2)阳性晚期胃癌患者中展现出具有统计学显著性且极具临床意义的总生存期(OS)改善。该试验纳入了局部晚期或转移性胃癌、胃食管结合部(GEJ)癌或食管腺癌(EAC)患者，入组标准为任意染色强度下至少25%的肿瘤细胞表达CLDN18.2。据估计，约60%的胃癌╱GEJ癌在≥25%的肿瘤细胞中表达 CLDN18.2。在美国、欧盟、中国和日本，每年约有18.35万名患者因CLDN18.2 阳性、HER2阴性的晚期或转移性胃癌╱GEJ癌接受二线及后线治疗。

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