Dr. Mehmet Oz took to the stage to promote the administration's initiatives aimed at lowering healthcare costs, such as Trump Rx, the federal government's drug-pricing website. The Centers for Medicare and Medicaid chief also touted administration support for GLP-1s, and the drugs' potential to reduce obesity.

Oz, who helped negotiate lower drug prices for GLP-1s for eligible Medicare and Medicaid recipients, said the weight-loss medications were "contributing to historic American weight loss," while telling the crowd: "So many of you look like gazelles tonight, probably for that reason." On the campaign trail, Trump often tells a story about an overweight wealthy friend who takes "the fat drug" to highlight the GLP-1 price disparity in the U.S. and abroad, although the president has at times quipped that it didn't work.

Oz also highlighted the administration's efforts to crack down on healthcare fraud, repeating a story he often tells about a student basketball player who died after alleged medical malpractice. "We must challenge this evil corruption," Oz said.