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Vertex Pharmaceuticals

456.20

+8.821.97%

Post-market: 455.90-0.3000-0.07%19:40 EST

Volume:5.56M

Turnover:2.53B

Market Cap:115.75B

PE:32.08

High:460.40

Open:446.86

Low:445.51

Close:447.38

52wk High:519.68

52wk Low:362.50

Shares:253.72M

Float Shares:253.72M

Volume Ratio:4.20

T/O Rate:2.19%

Dividend:- -

Dividend Rate:- -

EPS(TTM):14.22

EPS(LYR):-2.0768

ROE:22.31%

ROA:12.04%

PB:6.68

PE(LYR):-219.67

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Overview Company News Filings

Is CASGEVY’s Pediatric Breakthrough And Priority Review Altering The Investment Case For Vertex (VRTX)?

Simply Wall St.

Vertex Pharmaceuticals Inc. Stock Outperforms Competitors On Strong Trading Day

Post-AI Rally: Four Defensive Stocks to Watch for 2026

Vertex Pharmaceuticals Inc. Stock Underperforms Wednesday When Compared To Competitors

Vertex Pharmaceuticals (VRTX): Valuation Check After Positive Pediatric CASGEVY Data and Priority FDA Review Voucher

Simply Wall St.

Vertex Pharmaceuticals Inc. Stock Outperforms Competitors On Strong Trading Day

Wells Fargo Adjusts PT on Vertex Pharmaceuticals to $515 From $460, Maintains Overweight Rating

MT Newswires Live

Vertex Pharmaceuticals Incorporated : Wells Fargo Raises Target Price to $515 From $460

THOMSON REUTERS

Vertex 1H Net Y1.44B Vs Net Y1.45B

Vertex Pharmaceuticals Inc. Stock Underperforms Monday When Compared To Competitors

Disney, Nu Holdings, Phillips 66 And A Health Care Stock On CNBC's 'Final Trades'

Vertex's Gene Therapy Works In Children With Blood Disorders

Reassessing Vertex Pharmaceuticals After Pipeline Progress and Recent 7% Share Price Jump

Simply Wall St.

Vertex Minerals Says New South Wales Gold Mine Underground Loader Loads Ore from Stope by Remote Control

MT Newswires Live

Vertex (VERX): Valuation Check After Expanded AI Tax Compliance Partnership With CPA.com

Simply Wall St.

Vertex Unveils Positive CASGEVY Data in Children and Plans Global Submissions

Vertex Presents New Data on Casgevy®, Including First-Ever Data in Children Ages 5-11 Years, at the American Society of Hematology Annual Meeting and Announces Plan for Global Regulatory Submissions

THOMSON REUTERS

Vertex Pharmaceuticals: Presents New Data on Casgevy, Including First-Ever Data in Children Ages 5-11 Years

THOMSON REUTERS

Vertex: Consistent With Studies in Older Patients, Children Treated With Casgevy Have Durable Increases in Fetal Hemoglobin & Stable Allelic Editing

THOMSON REUTERS

Vertex's gene therapy shows promise in younger children with blood disorders

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CASGEVY’s Pediatric Breakthrough And Priority Review Altering The Investment Case For Vertex (VRTX)?","url":"https://stock-news.laohu8.com/highlight/detail?id=2593861144","media":"Simply Wall St.","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2593861144?lang=en_us&edition=fundamental","pubTime":"2025-12-21 02:15","pubTimestamp":1766254516,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals recently reported new clinical data showing that all evaluable children aged 5–11 treated with CASGEVY achieved key endpoints in sickle cell disease and transfusion-dependent beta thalassemia, and also secured an FDA National Priority Voucher to accelerate review in this younger age group.\nBy pairing strong pediatric efficacy signals with an expedited U.S. regulatory review pathway, Vertex is strengthening CASGEVY’s potential role in reshaping treatment for severe...","market":"us","thumbnail":"https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/is-casgevys-pediatric-breakthrough-and-priority-review-alter","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/is-casgevys-pediatric-breakthrough-and-priority-review-alter","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["IE00BZ9MQY76.HKD","IE00B19Z9Z06.USD","LU0109394709.USD","LU1035775433.USD","VERX","LU0061475181.USD","LU1585245621.USD","VRTX","LU2362541513.USD","IE0009355771.USD","IE00B2B36J28.USD","LU0889565916.HKD","LU2462157665.USD","IE00BJT1NW94.SGD","IE00BJJMRZ35.SGD","LU2362541273.HKD","LU2456880835.USD","BK4533","BK4023","LU0823416689.USD","BK4585","IE00B4R5TH58.HKD","LU1674673428.USD","LU1815336091.USD","LU0079474960.USD","LU2324357040.USD","BK4567","LU0417517546.SGD","LU2236285917.USD","LU2362540622.SGD","LU1093756168.USD","BK4588","LU0566484027.USD","BK4139","SGXZ57979304.SGD","LU0289739699.SGD","LU1093756325.SGD","LU0234570918.USD","LU0432979614.USD","IE00B894F039.SGD","IE0002141913.USD","IE00BFTCPJ56.SGD","IE00B19Z9P08.USD","LU1674673691.USD","LU1069344957.HKD","SG9999001176.USD","IE00B19Z3B42.SGD","BK4532","LU0256863811.USD","LU0058720904.USD"],"gpt_icon":0},{"id":"2592909821","title":"Vertex Pharmaceuticals Inc. Stock Outperforms Competitors On Strong Trading Day","url":"https://stock-news.laohu8.com/highlight/detail?id=2592909821","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592909821?lang=en_us&edition=fundamental","pubTime":"2025-12-20 05:37","pubTimestamp":1766180220,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Vertex Pharmaceuticals Inc.  rallied 1.97% to $456.20 Friday, on what proved to be an all-around positive trading session for the stock market, with the S&P 500 Index  rising 0.88% to 6,834.50 and the Dow Jones Industrial Average  rising 0.38% to 48,134.89.The stock's rise snapped a three-day losing streak.Vertex Pharmaceuticals Inc. closed 12.22% below its 52-week high of $519.68, which the company reached on March 14th.The stock demonstrated a mixed performance when compared to some of its competitors Friday, as AbbVie Inc.  rose 1.80% to $226.82, Krystal Biotech Inc.  rose 3.18% to $240.80, and Arcturus Therapeutics Holdings Inc.  rose 1.56% to $6.53.Trading volume  eclipsed its 50-day average volume of 1.3 M.Data source: Dow Jones Market Data, FactSet. Data compiled December 19, 2025.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is p","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["VRTX","VERX"],"gpt_icon":0},{"id":"1124158805","title":"Post-AI Rally: Four Defensive Stocks to Watch for 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=1124158805","media":"Stock News","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1124158805?lang=en_us&edition=fundamental","pubTime":"2025-12-19 15:05","pubTimestamp":1766127946,"startTime":"0","endTime":"0","summary":"After significant gains, the AI-driven tech sector is on track for a third consecutive year of over 20% growth. However, December's divergent performance among tech stocks suggests narrowing...","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU2362541273.HKD","LU1778281490.HKD","LU2456880835.USD","LU1674673691.USD","LU1069344957.HKD","BK4208","IE00BMG7P926.USD","BK4533","LU0432979614.USD","IE00B2B36J28.USD","LU0289739699.SGD","LU2236285917.USD","BK4532","LU2362541513.USD","BK4588","PEG","SG9999001176.SGD","IE00B19Z9Z06.USD","VRTX","LU0079474960.USD","LU0320765992.SGD","LU2237438978.USD","IE00B4R5TH58.HKD","LU0109394709.USD","LU1093756325.SGD","LU2346227817.USD","IE0009355771.USD","IE00B19Z3B42.SGD","IE00BJT1NW94.SGD","LU1585245621.USD","IE00BFTCPJ56.SGD","IE00BD4GTV84.USD","IE00B894F039.SGD","SGXZ57979304.SGD","LU2324357040.USD","LU1035775433.USD","LU0256863811.USD","LU1674673428.USD","IE0002141913.USD","IE00B19Z9P08.USD","IE00BD4GTT62.SGD","BK4585","LU0823416689.USD","LU0234570918.USD","LU0889565916.HKD","BK4567","SG9999013999.USD","IE00BMG7P587.USD","IE00BZ9MQY76.HKD","SG9999001176.USD","LU2417539215.USD","IE00BMG7P819.SGD","EPS","IE00BJJMRZ35.SGD","BK4139","IE0002270589.USD","LU0061475181.USD","LU0417517546.SGD","LU0058720904.USD","LU1430594728.SGD","LU2362540622.SGD","IE00BMG7P694.USD","LU2462157665.USD","IE00B19Z3581.USD","IE00BD4GTW91.USD","LU1093756168.USD"],"gpt_icon":0},{"id":"2592459519","title":"Vertex Pharmaceuticals Inc. Stock Underperforms Wednesday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2592459519","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592459519?lang=en_us&edition=fundamental","pubTime":"2025-12-18 05:38","pubTimestamp":1766007480,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Vertex Pharmaceuticals Inc.  slid 1.20% to $449.52 Wednesday, on what proved to be an all-around poor trading session for the stock market, with the S&P 500 Index  falling 1.16% to 6,721.43 and Dow Jones Industrial Average  falling 0.47% to 47,885.97.This was the stock's second consecutive day of losses.Vertex Pharmaceuticals Inc. closed 13.50% short of its 52-week high of $519.68, which the company reached on March 14th.The stock demonstrated a mixed performance when compared to some of its competitors Wednesday, as AbbVie Inc.  rose 0.29% to $224.31, Krystal Biotech Inc.  fell 1.15% to $235.80, and Arcturus Therapeutics Holdings Inc.  fell 8.56% to $6.52.Data source: Dow Jones Market Data, FactSet. Data compiled December 17, 2025.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The W","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["VERX","VRTX"],"gpt_icon":0},{"id":"2592911603","title":"Vertex Pharmaceuticals (VRTX): Valuation Check After Positive Pediatric CASGEVY Data and Priority FDA Review Voucher","url":"https://stock-news.laohu8.com/highlight/detail?id=2592911603","media":"Simply Wall St.","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592911603?lang=en_us&edition=fundamental","pubTime":"2025-12-17 21:18","pubTimestamp":1765977510,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals (VRTX) just delivered encouraging pediatric data for its gene editing therapy CASGEVY in sickle cell and beta thalassemia, and secured an FDA priority voucher that could accelerate review for children ages 5 to 11.\nSee our latest analysis for Vertex Pharmaceuticals.\nInvestors seem to be warming back up to that growth story, with Vertex’s share price at around $454.96 and a solid 90 day share price return of 17.52 percent. This is occurring even though the 1 year total...","market":"sg","thumbnail":"https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/vertex-pharmaceuticals-vrtx-valuation-check-after-positive-p","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/vertex-pharmaceuticals-vrtx-valuation-check-after-positive-p","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4585","IE00BFTCPJ56.SGD","BK4532","IE00B4R5TH58.HKD","LU0256863811.USD","IE00B19Z3B42.SGD","LU2462157665.USD","IE00BJT1NW94.SGD","LU2456880835.USD","IE0002141913.USD","LU0109394709.USD","SGXZ57979304.SGD","IE00BJJMRZ35.SGD","LU1035775433.USD","LU1674673428.USD","LU0823416689.USD","VERX","IE00B19Z3581.USD","IE00B19Z9Z06.USD","BK4588","LU1778281490.HKD","LU2362541513.USD","LU0289739699.SGD","BK4139","BK4533","LU0566484027.USD","IE00B2B36J28.USD","LU2324357040.USD","LU2417539215.USD","LU0079474960.USD","LU1815336091.USD","BK4023","BK4567","SG9999001176.SGD","LU0417517546.SGD","IE00BZ9MQY76.HKD","LU2237438978.USD","LU0889565916.HKD","SG9999001176.USD","IE0002270589.USD","VRTX","IE0009355771.USD","IE00B19Z9P08.USD","LU1559883803.SGD","LU0234570918.USD","LU1093756325.SGD","SG9999013999.USD","LU1430594728.SGD","LU0320765992.SGD","LU0432979614.USD"],"gpt_icon":0},{"id":"2590269553","title":"Vertex Pharmaceuticals Inc. Stock Outperforms Competitors On Strong Trading Day","url":"https://stock-news.laohu8.com/highlight/detail?id=2590269553","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590269553?lang=en_us&edition=fundamental","pubTime":"2025-12-11 05:39","pubTimestamp":1765402740,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Vertex Pharmaceuticals Inc.  rallied 1.75% to $444.64 Wednesday, on what proved to be an all-around great trading session for the stock market, with the S&P 500 Index  rising 0.67% to 6,886.68 and the Dow Jones Industrial Average  rising 1.05% to 48,057.75.The stock's rise snapped a four-day losing streak.Vertex Pharmaceuticals Inc. closed 14.44% short of its 52-week high of $519.68, which the company achieved on March 14th.The stock demonstrated a mixed performance when compared to some of its competitors Wednesday, as AbbVie Inc.  rose 0.98% to $225.18, Krystal Biotech Inc.  rose 2.17% to $239.72, and Arcturus Therapeutics Holdings Inc.  rose 6.53% to $7.67.Trading volume  remained 414,067 below its 50-day average volume of 1.4 M.Data source: Dow Jones Market Data, FactSet. Data compiled December 10, 2025.This content was created by MarketWatch, which is operated by Dow Jones & ","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["VRTX","VERX"],"gpt_icon":0},{"id":"2590058435","title":"Wells Fargo Adjusts PT on Vertex Pharmaceuticals to $515 From $460, Maintains Overweight Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2590058435","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590058435?lang=en_us&edition=fundamental","pubTime":"2025-12-10 20:11","pubTimestamp":1765368673,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals (VRTX) has an average rating of overweight and mean price target of $494.44, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["VRTX","PT","VERX"],"gpt_icon":0},{"id":"2590658914","title":"Vertex Pharmaceuticals Incorporated : Wells Fargo Raises Target Price to $515 From $460","url":"https://stock-news.laohu8.com/highlight/detail?id=2590658914","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590658914?lang=en_us&edition=fundamental","pubTime":"2025-12-10 19:30","pubTimestamp":1765366227,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251210:nAZN4RCSON:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IE00BJJMRZ35.SGD","LU0889565916.HKD","LU1778281490.HKD","BK4585","LU0109394709.USD","IE00B19Z3B42.SGD","IE00BFTCPJ56.SGD","LU0417517546.SGD","LU2324357040.USD","IE00B894F039.SGD","IE0002270589.USD","SGXZ57979304.SGD","IE00B2B36J28.USD","LU2456880835.USD","SG9999013999.USD","IE00B19Z9Z06.USD","BK4533","LU2236285917.USD","BK4139","BK4567","LU0058720904.USD","LU1430594728.SGD","SG9999001176.USD","LU1035775433.USD","LU0256863811.USD","BK4532","IE00BZ9MQY76.HKD","LU1093756168.USD","LU2462157665.USD","LU1585245621.USD","IE0009355771.USD","IE00BJT1NW94.SGD","LU0234570918.USD","LU1674673691.USD","SG9999001176.SGD","LU1674673428.USD","LU2237438978.USD","LU2362541513.USD","LU2417539215.USD","LU0061475181.USD","BK4588","VRTX","LU0079474960.USD","LU0432979614.USD","IE00B19Z9P08.USD","IE00B4R5TH58.HKD","LU0320765992.SGD","LU2362541273.HKD","LU1069344957.HKD","LU1093756325.SGD"],"gpt_icon":0},{"id":"2590307522","title":"Vertex 1H Net Y1.44B Vs Net Y1.45B","url":"https://stock-news.laohu8.com/highlight/detail?id=2590307522","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590307522?lang=en_us&edition=fundamental","pubTime":"2025-12-10 16:43","pubTimestamp":1765356180,"startTime":"0","endTime":"0","summary":"This content was automatically published based on data and/or text from the original source. For feedback, write to singaporeeditors@dowjones.com.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0061475181.USD","LU0566484027.USD","LU0079474960.USD","IE00B19Z9P08.USD","LU0889565916.HKD","IE00B2B36J28.USD","LU1778281490.HKD","IE0002141913.USD","SG9999001176.USD","VERX","LU0823416689.USD","LU2456880835.USD","IE0002270589.USD","IE00B19Z9Z06.USD","BK4533","LU2362541513.USD","LU2362540622.SGD","LU2462157665.USD","LU1559883803.SGD","IE00BFTCPJ56.SGD","LU0109394709.USD","LU1674673428.USD","VRTX","LU0256863811.USD","IE00B19Z3581.USD","LU0757428866.USD","LU1430594728.SGD","BK4023","BK4532","SG9999001176.SGD","IE00BJJMRZ35.SGD","LU1674673691.USD","SGXZ57979304.SGD","LU2236285917.USD","BK4567","IE00B894F039.SGD","LU0432979614.USD","LU0320765992.SGD","BK4139","IE0009355771.USD","LU1093756168.USD","LU2324357040.USD","IE00B4R5TH58.HKD","LU2237438978.USD","IE00B19Z3B42.SGD","LU0289739699.SGD","IE00BZ9MQY76.HKD","LU1093756325.SGD","LU1585245621.USD","LU1815336091.USD"],"gpt_icon":0},{"id":"2590932366","title":"Vertex Pharmaceuticals Inc. Stock Underperforms Monday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2590932366","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590932366?lang=en_us&edition=fundamental","pubTime":"2025-12-09 05:38","pubTimestamp":1765229880,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Vertex Pharmaceuticals Inc.  slid 2.95% to $442.04 Monday, on what proved to be an all-around poor trading session for the stock market, with the S&P 500 Index  falling 0.35% to 6,846.51 and Dow Jones Industrial Average  falling 0.45% to 47,739.32.This was the stock's third consecutive day of losses.Vertex Pharmaceuticals Inc. closed 14.94% below its 52-week high of $519.68, which the company reached on March 14th.The stock underperformed when compared to some of its competitors Monday, as AbbVie Inc.  fell 1.31% to $223.12, Krystal Biotech Inc.  fell 0.03% to $234.05, and Arcturus Therapeutics Holdings Inc.  rose 4.49% to $7.45.Trading volume  eclipsed its 50-day average volume of 1.4 M.Data source: Dow Jones Market Data, FactSet. Data compiled December 8, 2025.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently fro","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["VRTX","VERX"],"gpt_icon":0},{"id":"2590357321","title":"Disney, Nu Holdings, Phillips 66 And A Health Care Stock On CNBC's 'Final Trades'","url":"https://stock-news.laohu8.com/highlight/detail?id=2590357321","media":"Benzinga","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590357321?lang=en_us&edition=fundamental","pubTime":"2025-12-08 23:44","pubTimestamp":1765208640,"startTime":"0","endTime":"0","summary":"Nu Holdings, Phillips 66, Vertex Pharmaceuticals and Disney get shoutouts on CNBC's \"Halftime Report Final Trades.\"","market":"hk","thumbnail":"https://cdn.benzinga.com/files/images/story/2025/12/08/Nu-Holdings.jpeg?optimize=medium&dpr=2&auto=webp&width=260","type":0,"news_type":0,"thumbnails":["https://cdn.benzinga.com/files/images/story/2025/12/08/Nu-Holdings.jpeg?optimize=medium&dpr=2&auto=webp&width=260"],"rights":{"source":"benzinga_hot_news","url":"https://www.benzinga.com/analyst-stock-ratings/analyst-color/25/12/49259985/nu-holdings-disney-phillips-66-health-care-stock-cnbc-final-trades","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/analyst-stock-ratings/analyst-color/25/12/49259985/nu-holdings-disney-phillips-66-health-care-stock-cnbc-final-trades","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_hot_news","symbols":["NU","LU0050427557.USD","LU0109394709.USD","LU2456880835.USD","BK4561","LU0210535034.USD","BK4139","VRTX","LU0072463663.USD","LU2133065610.SGD","IE00B3T34201.USD","LU0742534661.SGD","LU0029864427.USD","SGXZ57979304.SGD","BK4551","IE00BZ1G4Q59.USD","BK4588","LU0196696453.USD","LU0143863784.USD","LU0640476718.USD","IE00BJJMRZ35.SGD","BK4559","LU1720051017.SGD","LU1894683264.USD","BK4207","IE00BFTCPJ56.SGD","LU2045819591.USD","PSX","LU1861217088.USD","IE00B2B36J28.USD","LU0254981946.USD","LU0456842615.SGD","LU0788109048.HKD","LU0980610538.SGD","LU1201861249.SGD","IE00B894F039.SGD","SG9999015986.USD","DIS","LU0048575426.USD","LU0128525929.USD","LU0234570918.USD","LU1732800096.USD","LU1069347547.HKD","IE00B7SZLL34.SGD","LU2347655156.SGD","IE00B19Z9P08.USD","LU0214875030.USD","LU0058720904.USD","BK4108","LU0143863198.USD"],"gpt_icon":1},{"id":"2589554843","title":"Vertex's Gene Therapy Works In Children With Blood Disorders","url":"https://stock-news.laohu8.com/highlight/detail?id=2589554843","media":"Benzinga","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589554843?lang=en_us&edition=fundamental","pubTime":"2025-12-08 21:18","pubTimestamp":1765199880,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals Incorporated  on Saturday presented data from multiple studies demonstrating the clinical benefits of Casgevy  in patients aged 5 years and older with severe sickle cell disease  or transfusion-dependent beta thalassemia .SCD is a severe inherited blood disease that damages red blood cells, limits oxygen delivery, causes intense pain, and can shorten life.TDT is a life-threatening genetic condition that forces patients to rely on regular blood transfusions and lifelong treatment to remove excess iron.Also Read: FDA Fast-Tracks 6 More Drugs – Obesity And Cancer Drugs Included. In children with SCD, 11 patients have been dosed with Casgevy in the Phase 3 CLIMB-151 clinical study, and all (4/4) patients with sufficient follow-up achieved the primary endpoint of being free from vaso-occlusive crises  for at least 12 consecutive months .In children with TDT, 13 patients have been dosed with Casgevy in the Phase 3 CLIMB-141 clinical study, and all (6/6) patients with s","market":"us","thumbnail":"https://cdn.benzinga.com/files/images/story/2025/12/08/Vertex-Pharmaceuticals-Inc-.jpeg?optimize=medium&dpr=2&auto=webp&width=630","type":0,"news_type":0,"thumbnails":["https://cdn.benzinga.com/files/images/story/2025/12/08/Vertex-Pharmaceuticals-Inc-.jpeg?optimize=medium&dpr=2&auto=webp&width=630"],"rights":{"source":"benzinga_hot_news","url":"https://www.benzinga.com/news/health-care/25/12/49254689/vertexs-gene-therapy-works-in-children-with-blood-disorders","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/health-care/25/12/49254689/vertexs-gene-therapy-works-in-children-with-blood-disorders","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_hot_news","symbols":["IE00B894F039.SGD","LU0320765992.SGD","LU0432979614.USD","LU2462157665.USD","VERX","LU2417539215.USD","LU0109394709.USD","IE0009355771.USD","LU0566484027.USD","IE00B19Z9Z06.USD","LU0889565916.HKD","LU1585245621.USD","IE00B19Z3581.USD","IE0002141913.USD","IE00BJJMRZ35.SGD","LU1674673691.USD","LU1778281490.HKD","LU1093756325.SGD","ASH","LU2463526074.USD","VRTX","IE00B19Z9P08.USD","SG9999013999.USD","IE00BZ9MQY76.HKD","IE00BJT1NW94.SGD","IE00B19Z3B42.SGD","SG9999001176.USD","LU2324357040.USD","LU2362541513.USD","LU0289739699.SGD","LU1069344957.HKD","IE00BFTCPJ56.SGD","SCD","LU0234570918.USD","LU1093756168.USD","LU2237438978.USD","IE0002270589.USD","IE00B2B36J28.USD","LU1674673428.USD","LU0256863811.USD","BK4139","LU0823416689.USD","BK4567","BK4588","BK4532","LU1815336091.USD","LU0058720904.USD","LU0061475181.USD","LU0417517546.SGD","SG9999001176.SGD"],"gpt_icon":0},{"id":"2589476382","title":"Reassessing Vertex Pharmaceuticals After Pipeline Progress and Recent 7% Share Price Jump","url":"https://stock-news.laohu8.com/highlight/detail?id=2589476382","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589476382?lang=en_us&edition=fundamental","pubTime":"2025-12-08 13:16","pubTimestamp":1765171012,"startTime":"0","endTime":"0","summary":"If you are wondering whether Vertex Pharmaceuticals at around $455 a share is still a smart buy or if the best days are already priced in, you are not alone.\nThe stock has climbed 7.0% over the last week and 11.2% over the past month. It is still only up 12.3% year to date and is actually down 3.9% over the last year, despite a strong 45.0% three year and 99.7% five year run.\nRecent headlines have focused on Vertex's expanding pipeline in cystic fibrosis and non opioid pain, along with...","market":"hk","thumbnail":"https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/company-cover/36235-main-header/1756253398031"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/reassessing-vertex-pharmaceuticals-after-pipeline-progress-a","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-vrtx/vertex-pharmaceuticals/news/reassessing-vertex-pharmaceuticals-after-pipeline-progress-a","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["LU2456880835.USD","LU1093756168.USD","VERX","IE00BZ9MQY76.HKD","LU0061475181.USD","BK4533","LU1035775433.USD","LU1674673691.USD","IE00B19Z3B42.SGD","IE00B19Z9P08.USD","PRGS","LU2065732104.USD","LU1778281490.HKD","LU0289739699.SGD","BK4588","LU2462157665.USD","BK4532","LU1430594728.SGD","LU0109394709.USD","LU1815336091.USD","LU1093756325.SGD","SG9999001176.USD","SGXZ57979304.SGD","BK4567","LU0058720904.USD","LU0432979614.USD","IE00B19Z3581.USD","BK4023","LU2362541513.USD","LU0889565916.HKD","LU2236285917.USD","LU1069344957.HKD","IE00B19Z9Z06.USD","LU0757428866.USD","SG9999001176.SGD","BK4139","VRTX","IE00B894F039.SGD","DCF","IE0002141913.USD","LU0566484027.USD","LU0234570918.USD","IE00BJJMRZ35.SGD","LU2362540622.SGD","IE0009355771.USD","IE00B4R5TH58.HKD","IE00BFTCPJ56.SGD","IE00B2B36J28.USD","LU0320765992.SGD","LU1585245621.USD"],"gpt_icon":0},{"id":"2589038863","title":"Vertex Minerals Says New South Wales Gold Mine Underground Loader Loads Ore from Stope by Remote Control","url":"https://stock-news.laohu8.com/highlight/detail?id=2589038863","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589038863?lang=en_us&edition=fundamental","pubTime":"2025-12-08 10:44","pubTimestamp":1765161852,"startTime":"0","endTime":"0","summary":"Vertex Minerals  said that the Aramine underground loader loaded ore from the 1438 north stope by remote control at its Reward gold mine in New South Wales, according to a Monday Australian bourse filing.The firm's Chairman, Roger Jackson, said the equipment needed to be purposely commissioned, and the tele remote hut is designed specifically for the Reward mine and can be moved around on a skid steer.Its gold production ramp-up is progressing, and the firm is beginning to see gold grades increase as it goes to areas of planned development and production activity.The firm's shares fell 2% in recent trading on Monday.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4567","IE00B2B36J28.USD","IE00BZ9MQY76.HKD","VRTX","BK4109","BK4023","LU2237438978.USD","LU0234570918.USD","1OZmain","IE0002270589.USD","VTX.AU","LU0566484027.USD","LU0757428866.USD","LU0256863811.USD","VERX","LU0823416689.USD","IE00B894F039.SGD","LU2417539215.USD","MTX","BK4585","LU1093756325.SGD","IE00B19Z9P08.USD","SG9999001176.USD","LU0079474960.USD","LU2462157665.USD","IE00B4R5TH58.HKD","BK4532","LU0889565916.HKD","LU0061475181.USD","BK4588","LU1035775433.USD","LU1559883803.SGD","LU1674673691.USD","LU2456880835.USD","SG9999001176.SGD","LU0320765992.SGD","IE00BFTCPJ56.SGD","IE00BJJMRZ35.SGD","LU0109394709.USD","LU1430594728.SGD","SG9999013999.USD","LU1674673428.USD","LU2362541513.USD","BK7104","LU2362540622.SGD","LU1585245621.USD","LU0417517546.SGD","LU0058720904.USD","IE00B19Z3581.USD","BK4533"],"gpt_icon":0},{"id":"2589787457","title":"Vertex (VERX): Valuation Check After Expanded AI Tax Compliance Partnership With CPA.com","url":"https://stock-news.laohu8.com/highlight/detail?id=2589787457","media":"Simply Wall St.","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589787457?lang=en_us&edition=fundamental","pubTime":"2025-12-07 18:14","pubTimestamp":1765102474,"startTime":"0","endTime":"0","summary":"Vertex (VERX) has expanded its long-running partnership with CPA.com, rolling out an AI-powered sales tax compliance platform built with Kintsugi. The move directly targets accounting firms looking to automate complex, recurring tax workflows.\nSee our latest analysis for Vertex.\nDespite solid revenue growth and the new AI collaboration with CPA.com and Kintsugi, Vertex’s 90 day share price return of minus 24.1 percent and 1 year total shareholder return of minus 65.05 percent suggest...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/8041000-choice2-main-header/1585186556238","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/8041000-choice2-main-header/1585186556238"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/software/nasdaq-verx/vertex/news/vertex-verx-valuation-check-after-expanded-ai-tax-compliance","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/software/nasdaq-verx/vertex/news/vertex-verx-valuation-check-after-expanded-ai-tax-compliance","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["IE0009355771.USD","LU1430594728.SGD","LU0109394709.USD","VRTX","LU0823416689.USD","LU2324357040.USD","LU1093756325.SGD","LU1674673428.USD","IE00B19Z3B42.SGD","LU0889565916.HKD","SG9999001176.USD","IE00B4R5TH58.HKD","SGXZ57979304.SGD","BK4551","BK4139","VERX","LU2236285917.USD","IE00BZ9MQY76.HKD","LU2362541273.HKD","LU1093756168.USD","BK4543","LU0566484027.USD","LU0432979614.USD","LU2462157665.USD","LU0061475181.USD","AI","LU1778281490.HKD","BK4532","IE00B19Z9P08.USD","BK4023","LU2362541513.USD","LU2417539215.USD","LU1815336091.USD","LU0320765992.SGD","IE0002141913.USD","BK4533","IE00B894F039.SGD","IE00BFTCPJ56.SGD","BK4528","LU1559883803.SGD","LU2237438978.USD","IE0002270589.USD","IE00B19Z9Z06.USD","BK4588","LU1674673691.USD","LU0058720904.USD","LU0757428866.USD","LU1069344957.HKD","IE00B19Z3581.USD","LU0289739699.SGD"],"gpt_icon":0},{"id":"2589823748","title":"Vertex Unveils Positive CASGEVY Data in Children and Plans Global Submissions","url":"https://stock-news.laohu8.com/highlight/detail?id=2589823748","media":"Reuters","labels":["productRelease","dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589823748?lang=en_us&edition=fundamental","pubTime":"2025-12-06 20:01","pubTimestamp":1765022480,"startTime":"0","endTime":"0","summary":"Vertex Pharmaceuticals Incorporated has announced new clinical data on CASGEVY  in children aged 5-11 years with severe sickle cell disease or transfusion-dependent beta thalassemia. The data, which were presented at the American Society of Hematology  Annual Meeting, are the first-ever clinical results for any genetic therapy in this age group. The efficacy and safety outcomes in children aged 5-11 years were consistent with previously established data in patients aged 12 years and older. Vertex reported that enrollment and dosing for the 5-11 years cohort are complete, and the company plans to initiate global regulatory submissions, including a supplemental Biologics License Application in the U.S., in the first half of 2026. CASGEVY is currently approved for eligible patients aged 12 years and older in multiple countries.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely 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