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Verastem

4.96

-0.3300-6.24%

Volume:1.01M

Turnover:5.11M

Market Cap:435.66M

PE:-1.64

High:5.29

Open:5.29

Low:4.93

Close:5.29

52wk High:11.25

52wk Low:4.01

Shares:87.84M

Float Shares:75.06M

Volume Ratio:0.39

T/O Rate:1.35%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.0223

EPS(LYR):-3.0223

ROE:-1480.15%

ROA:-61.11%

PB:7.62

PE(LYR):-1.64

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Overview Company News Filings

Stock Track | Verastem Plunges 6% Pre-Market Despite Q3 Revenue Beat as Losses Widen

Verastem Oncology Q3 revenue hits $11.2 mln, net loss widens

Verastem posts Q3 net loss of $98.5 million

BRIEF-Verastem Q3 Net Income USD -98.518 Million

Verastem Inc - Qtrly Adj Net Loss $0.54 per Share

THOMSON REUTERS

Verastem Q3 Operating Expenses USD 51.957 Million

THOMSON REUTERS

Verastem price target raised to $15 from $14 at Mizuho

Verastem Inc : Mizuho Raises Target Price to $15 From $14

THOMSON REUTERS

BRIEF-Verastem Oncology Announces Encouraging Preliminary Data From Ongoing Phase 1/2A Dose Escalation Trial Of Versus-7375, An Oral Kras G12d (On/Off) Inhibitor, In Patients With Kras G12d Mutant Solid Tumors

Verastem Reports Promising Phase 1/2a Trial Data

Verastem Reports Encouraging Early Results for KRAS G12D Inhibitor in Ongoing Phase 1/2a Trial

Verastem Inc - Interim Safety and Efficacy Update Planned for First Half of 2026

THOMSON REUTERS

Verastem Oncology Announces Encouraging Preliminary Data From Ongoing Phase 1/2a Dose Escalation Trial of VS-7375, an Oral Kras G12d (on/off) Inhibitor, in Patients With Kras G12d Mutant Solid Tumors

THOMSON REUTERS

Verastem Inc - First Two Dose Levels Cleared With No Dose-Limiting Toxicities

THOMSON REUTERS

Verastem Says Median Overall Survival Not Reached in Partner's Phase 1/2 Pancreatic Cancer Study; Shares Fall

MT Newswires Live

Verastem data ‘best-in-class’ despite slight decline, says RBC Capital

Verastem: GFH375 resulted in 41% ORR in Phase 1/2 study

Guggenheim Reaffirms Their Buy Rating on Verastem (VSTM)

Verastem Reports 41% Response Rate in Phase 1/2 Trial of KRAS G12D Inhibitor for Advanced Pancreatic Cancer

Verastem Reports 41% Response Rate for KRAS G12D Inhibitor in Advanced Pancreatic Cancer Trial

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The biotechnology company's shares faced selling pressure as...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"ai_movement_en","symbols":["VSTM"],"gpt_icon":0},{"id":"2580739298","title":"Verastem Oncology Q3 revenue hits $11.2 mln, net loss widens","url":"https://stock-news.laohu8.com/highlight/detail?id=2580739298","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580739298?lang=en_us&edition=fundamental","pubTime":"2025-11-04 20:41","pubTimestamp":1762260103,"startTime":"0","endTime":"0","summary":"Verastem Oncology Q3 revenue hits $11.2 mln, net loss widensOverviewVerastem Q3 2025 net product revenue reaches $11.2 mln, marking successful product launchCompany reports Q3 net loss of $98.5 mln, r","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251104:nL1N3WG0LM:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["VSTM","BK4139"],"gpt_icon":0},{"id":"2580393377","title":"Verastem posts Q3 net loss of $98.5 million","url":"https://stock-news.laohu8.com/highlight/detail?id=2580393377","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2580393377?lang=en_us&edition=fundamental","pubTime":"2025-11-04 20:31","pubTimestamp":1762259479,"startTime":"0","endTime":"0","summary":"Verastem Oncology reported a GAAP net loss of $98.5 million, or $1.35 per share , for the third quarter ended September 30, 2025, compared to a GAAP net loss of $24.0 million, or $0.60 per share, for the same period in 2024. The non-GAAP adjusted net loss for the quarter was $39.4 million, or $0.54 per share , versus $35.3 million, or $0.88 per share , in the third quarter of 2024. The company ended the quarter with $137.7 million in cash, cash equivalents, and investments, and expects its cash runway to extend into the second half of 2026 with current resources including product revenue and exercise of cash warrants. Verastem also provided recent business updates during the period.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. 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Published first on TheFly – ...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/verastem-price-target-raised-to-15-from-14-at-mizuho-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/verastem-price-target-raised-to-15-from-14-at-mizuho-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["MFG","VSTM"],"gpt_icon":0},{"id":"2579979619","title":"Verastem Inc : Mizuho Raises Target Price to $15 From $14","url":"https://stock-news.laohu8.com/highlight/detail?id=2579979619","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2579979619?lang=en_us&edition=fundamental","pubTime":"2025-10-29 18:36","pubTimestamp":1761734205,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251029:nFWN3WA124:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["VSTM","BK4139"],"gpt_icon":0},{"id":"2577530510","title":"BRIEF-Verastem Oncology Announces Encouraging Preliminary Data From Ongoing Phase 1/2A Dose Escalation Trial Of Versus-7375, An Oral Kras G12d (On/Off) Inhibitor, In Patients With Kras G12d Mutant Solid Tumors","url":"https://stock-news.laohu8.com/highlight/detail?id=2577530510","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577530510?lang=en_us&edition=fundamental","pubTime":"2025-10-24 06:37","pubTimestamp":1761259046,"startTime":"0","endTime":"0","summary":"BRIEF-Verastem Oncology Announces Encouraging Preliminary Data From Ongoing Phase 1/2A Dose Escalation Trial Of Versus-7375, An Oral Kras G12d (On/Off) Inhibitor, In Patients With Kras G12d Mutant Sol","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251023:nTUA22JVTH:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577531889","title":"Verastem Reports Promising Phase 1/2a Trial Data","url":"https://stock-news.laohu8.com/highlight/detail?id=2577531889","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577531889?lang=en_us&edition=fundamental","pubTime":"2025-10-24 04:39","pubTimestamp":1761251944,"startTime":"0","endTime":"0","summary":"Verastem ( ($VSTM) ) just unveiled an announcement. On October 23, 2025, Verastem announced preliminary data from its ongoing Phase 1/2a trial of V...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/verastem-reports-promising-phase-1-2a-trial-data?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/verastem-reports-promising-phase-1-2a-trial-data?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577533008","title":"Verastem Reports Encouraging Early Results for KRAS G12D Inhibitor in Ongoing Phase 1/2a Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2577533008","media":"Reuters","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577533008?lang=en_us&edition=fundamental","pubTime":"2025-10-24 04:01","pubTimestamp":1761249688,"startTime":"0","endTime":"0","summary":"Verastem Inc. has announced encouraging preliminary data from its ongoing Phase 1/2a clinical trial evaluating VS-7375, an oral KRAS G12D  inhibitor, in patients with previously-treated advanced KRAS G12D mutant solid tumors. The first two monotherapy dose levels  have been cleared with no dose-limiting toxicities reported, and promising anti-tumor activity has been observed across various solid tumors, including advanced pancreatic ductal adenocarcinoma. Gastrointestinal tolerability has been favorable, with no nausea, vomiting, or diarrhea greater than Grade 1 observed. Patient enrollment has also begun for the first dose escalation combination cohort of VS-7375 with cetuximab in patients with advanced KRAS G12D mutant solid tumors, including colorectal cancer. Verastem plans to report an interim safety and efficacy update on the Phase 1/2a trial in the first half of 2026.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While P","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251023:nNDL7tcJFP:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577536612","title":"Verastem Inc - Interim Safety and Efficacy Update Planned for First Half of 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2577536612","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577536612?lang=en_us&edition=fundamental","pubTime":"2025-10-24 04:01","pubTimestamp":1761249660,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251023:nTUA22JVTH:4","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577533041","title":"Verastem Oncology Announces Encouraging Preliminary Data From Ongoing Phase 1/2a Dose Escalation Trial of VS-7375, an Oral Kras G12d (on/off) Inhibitor, in Patients With Kras G12d Mutant Solid Tumors","url":"https://stock-news.laohu8.com/highlight/detail?id=2577533041","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577533041?lang=en_us&edition=fundamental","pubTime":"2025-10-24 04:01","pubTimestamp":1761249660,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251023:nTUA22JVTH:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577366105","title":"Verastem Inc - First Two Dose Levels Cleared With No Dose-Limiting Toxicities","url":"https://stock-news.laohu8.com/highlight/detail?id=2577366105","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577366105?lang=en_us&edition=fundamental","pubTime":"2025-10-24 04:01","pubTimestamp":1761249660,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251023:nTUA22JVTH:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577786149","title":"Verastem Says Median Overall Survival Not Reached in Partner's Phase 1/2 Pancreatic Cancer Study; Shares Fall","url":"https://stock-news.laohu8.com/highlight/detail?id=2577786149","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577786149?lang=en_us&edition=fundamental","pubTime":"2025-10-21 00:53","pubTimestamp":1760979217,"startTime":"0","endTime":"0","summary":"Verastem  said Sunday that results from partner GenFleet Therapeutics' phase 1/2 study in China of GFH375 in patients with KRAS G12D mutant advanced pancreatic ductal adenocarcinoma did not meet the median overall survival at data cutoff.Among 59 heavily pre-treated patients, 40.7% achieved overall response rate at the 600 milligram daily dose, 91.5% experienced tumor reduction, and the disease control rate was 96.7%, the company said.The safety profile was consistent with previous findings indicating manageable tolerability with a 4% discontinuation rate due to adverse events, it said.Verastem shares were down 11% in recent Monday trading.Price: 8.24, Change: -0.98, Percent Change: -10.63","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2577869788","title":"Verastem data ‘best-in-class’ despite slight decline, says RBC Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2577869788","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577869788?lang=en_us&edition=fundamental","pubTime":"2025-10-21 00:20","pubTimestamp":1760977217,"startTime":"0","endTime":"0","summary":"RBC Capital keeps an Outperform rating on Verastem (VSTM) with a $13 price target after the company’s partner GenFleet Therapeutics reported Phase ...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/verastem-data-best-in-class-despite-slight-decline-says-rbc-capital-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/verastem-data-best-in-class-despite-slight-decline-says-rbc-capital-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4207","BK4139","VSTM","LU0310800379.SGD","LU0708994859.HKD","LU0128525929.USD","LU0029864427.USD","LU1267930573.SGD"],"gpt_icon":0},{"id":"2577869274","title":"Verastem: GFH375 resulted in 41% ORR in Phase 1/2 study","url":"https://stock-news.laohu8.com/highlight/detail?id=2577869274","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2577869274?lang=en_us&edition=fundamental","pubTime":"2025-10-21 00:10","pubTimestamp":1760976624,"startTime":"0","endTime":"0","summary":"Verastem (VSTM) Oncology on Sunday announced updated efficacy and safety data from partner GenFleet Therapeutics’ Phase 1/2 monotherapy study in Ch...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/verastem-gfh375-resulted-in-41-orr-in-phase-1-2-study-thefly?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/verastem-gfh375-resulted-in-41-orr-in-phase-1-2-study-thefly?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","ORR","VSTM"],"gpt_icon":0},{"id":"2576856455","title":"Guggenheim Reaffirms Their Buy Rating on Verastem (VSTM)","url":"https://stock-news.laohu8.com/highlight/detail?id=2576856455","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2576856455?lang=en_us&edition=fundamental","pubTime":"2025-10-20 19:36","pubTimestamp":1760960161,"startTime":"0","endTime":"0","summary":"In a report released yesterday, from Guggenheim maintained a Buy rating on Verastem, with a price target of $14.00. The company’s shares closed las...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/guggenheim-reaffirms-their-buy-rating-on-verastem-vstm-blurbs?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/guggenheim-reaffirms-their-buy-rating-on-verastem-vstm-blurbs?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["VSTM"],"gpt_icon":0},{"id":"2576830377","title":"Verastem Reports 41% Response Rate in Phase 1/2 Trial of KRAS G12D Inhibitor for Advanced Pancreatic Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2576830377","media":"Reuters","labels":["dataReport","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2576830377?lang=en_us&edition=fundamental","pubTime":"2025-10-20 18:05","pubTimestamp":1760954744,"startTime":"0","endTime":"0","summary":"Verastem Oncology has announced updated efficacy and safety results from GenFleet Therapeutics' Phase 1/2 monotherapy study of GFH375 , an oral KRAS G12D inhibitor, in patients with advanced KRAS G12D mutant pancreatic ductal adenocarcinoma . The data were presented as a late-breaking abstract at the European Society for Medical Oncology  Congress 2025 in Berlin, Germany. Among 59 efficacy-evaluable, heavily pre-treated patients receiving 600 mg daily, the overall response rate was 40.7%, and the disease control rate was 96.7%. At month four, the observed overall survival rate was 92.2%, with median overall survival not reached as of the data cutoff. The median progression-free survival was 5.52 months. The study reported a manageable safety profile, with a 4% discontinuation rate due to adverse events. At the time of evaluation, 47% of patients remained on treatment.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251020:nNDL7h0HpV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","VSTM"],"gpt_icon":0},{"id":"2576027945","title":"Verastem Reports 41% Response Rate for KRAS G12D Inhibitor in Advanced Pancreatic Cancer Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2576027945","media":"Reuters","labels":["dataReport","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2576027945?lang=en_us&edition=fundamental","pubTime":"2025-10-19 16:15","pubTimestamp":1760861722,"startTime":"0","endTime":"0","summary":"Verastem Oncology has announced updated efficacy and safety data from GenFleet Therapeutics' Phase 1/2 monotherapy study of GFH375 , an oral KRAS G12D  inhibitor, for patients with KRAS G12D mutant advanced pancreatic ductal adenocarcinoma . The study was conducted in China and included 66 patients, most of whom had stage IV disease and had received at least two prior lines of anticancer therapies. At the recommended Phase 2 dose of 600 mg daily, the overall response rate  among 59 efficacy-evaluable, heavily pre-treated patients was 40.7%, with a disease control rate  of 96.7%. Tumor reduction was observed in 91.5% of patients, and the four-month overall survival  rate was 92.2%. Median OS was not reached at the data cutoff of September 27, 2025, with a median follow-up of 5.65 months. The median progression-free survival  was 5.52 months, and nearly half of the patients remained on treatment at the time of evaluation. 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