Actuate Therapeutics Inc

2.29

-0.0300-1.29%

Volume:12.72K

Turnover:29.39K

Market Cap:53.23M

PE:-1.90

High:2.39

Open:2.31

Low:2.25

Close:2.32

52wk High:11.99

52wk Low:2.15

Shares:23.24M

Float Shares:9.28M

Volume Ratio:0.37

T/O Rate:0.14%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.2044

EPS(LYR):-3.2588

ROE:-296.04%

ROA:-95.25%

PB:4.87

PE(LYR):-0.70

Loading ...

Overview Company News Filings

Jul 23, 2024

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers | Global Stocks, Options & Futures Trading App","description":"Tiger Brokers, one-stop investment in US stocks, SGX stocks, HK stocks, A-shares & other global assets. One of the best stock trading platforms in Singapore.","keywords":"tiger brokers,tiger trade,tiger brokers singapore,broker online,stock trading in singapore,share trading singapore,brokerage firm singapore,trading app,stock broker singapore,stock trading platforms,trading account","social":{"ogDescription":"Tiger Brokers, one-stop investment in US stocks, SGX stocks, HK stocks, A-shares & other global assets. One of the best stock trading platforms in Singapore.","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.be62fbe1.png","ogUrl":"https://www.itiger.com/stock/ACTU/filings?page=3"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"SGP","license":"TBSG","edition":"fundamental","symbol":"ACTU","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"ACTU\",,,,,undefined,":{"symbol":"ACTU","market":"US","secType":"STK","nameCN":"Actuate Therapeutics Inc","latestPrice":2.29,"timestamp":1774539941494,"preClose":2.32,"halted":0,"volume":12723,"delay":0,"changeRate":-0.012931034482758537,"floatShares":9280300,"shares":23243328,"eps":-1.204351,"marketStatus":"Trading","change":-0.03,"latestTime":"03-26 11:46:56 EDT","open":2.31,"high":2.3853,"low":2.25,"amount":29394.6950124,"amplitude":0.058319,"askPrice":2.34,"askSize":101,"bidPrice":2.24,"bidSize":82,"shortable":3,"etf":0,"ttmEps":-1.204351,"tradingStatus":2,"nextMarketStatus":{"tag":"Post-Mkt","tradingStatus":3,"beginTime":1774555200000},"marketStatusCode":2,"adr":0,"listingDate":1723521600000,"exchange":"NASDAQ","adjPreClose":2.32,"postHourTrading":{"tag":"盘后","latestPrice":2.32,"preClose":2.32,"latestTime":"16:10 EDT","volume":4,"amount":9.28,"timestamp":1774469404984,"change":0,"changeRate":0,"amplitude":0},"volumeRatio":0.367132},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"ACTU\",,,,,undefined,":{"symbol":"ACTU","floatShares":9280300,"roa":"-95.25%","roe":"-296.04%","lyrEps":-3.258828,"volumeRatio":0.367132,"shares":23243328,"dividePrice":0,"high":2.3853,"amplitude":0.058319,"preClose":2.32,"low":2.25,"week52Low":2.15,"pbRate":"4.87","week52High":11.99,"institutionHeld":0,"latestPrice":2.29,"committee":-0.103825,"eps":-1.204351,"divideRate":0,"volume":12723,"delay":0,"ttmEps":-1.204351,"open":2.31,"prevYearClose":6.12,"prevWeekClose":2.35,"prevMonthClose":3.74,"prevQuarterClose":6.12,"fiveDayClose":2.5,"twentyDayClose":3.95,"sixtyDayClose":5.86},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/ACTU\",params:#limit:5,,,undefined,":[{"market":"US","date":"2025-11-13","symbol":"ACTU","fiscalQuarterEnding":"2025/09","expectedEps":-0.27,"name":null,"time":"Post Market","type":"earning","dateTimestamp":1763010000000,"reportTimeType":"post","actualEps":-0.25},{"market":"US","date":"2025-08-14","symbol":"ACTU","fiscalQuarterEnding":"2025/06","expectedEps":-0.19,"name":null,"time":"Post Market","type":"earning","dateTimestamp":1755144000000,"reportTimeType":"post","actualEps":-0.3},{"market":"US","date":"2025-05-15","symbol":"ACTU","fiscalQuarterEnding":"2025/03","expectedEps":-0.26,"name":null,"time":"Post Market","type":"earning","dateTimestamp":1747281600000,"reportTimeType":"post","actualEps":-0.32}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"ACTU\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"ACTU\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0,"buy":1,"hold":0,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":1,"analysts":4,"updateTime":1756180800000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/ACTU\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"ACTU","date":"2026-03-25","current":-1.926349,"percent":1,"low":-9.225925,"twenty":-6.610668,"median":-5.760243,"eighty":-4.881955,"high":-2.129676,"avg":-5.734156,"sd":1.120077,"marketCap":51367754},"quantilePoints":[{"date":"2024-07-25","current":-6.211408,"twenty":-6.211408,"median":-6.211408,"eighty":-6.211408,"marketCap":172493433},{"date":"2024-08-09","current":-5.505609,"twenty":-6.211408,"median":-6.211408,"eighty":-6.070248,"marketCap":152893088},{"date":"2024-08-16","current":-5.987349,"twenty":-6.211408,"median":-6.167236,"eighty":-5.841451,"marketCap":166271233},{"date":"2024-08-23","current":-5.560665,"twenty":-6.211408,"median":-5.987349,"eighty":-5.556536,"marketCap":154422018},{"date":"2024-08-30","current":-5.540019,"twenty":-6.211408,"median":-5.870355,"eighty":-5.533137,"marketCap":153848669},{"date":"2024-09-06","current":-5.608839,"twenty":-6.158401,"median":-5.624324,"eighty":-5.529008,"marketCap":155759833},{"date":"2024-09-13","current":-5.512491,"twenty":-6.078798,"median":-5.608839,"eighty":-5.512491,"marketCap":153084204},{"date":"2024-09-20","current":-5.03075,"twenty":-6.012125,"median":-5.608839,"eighty":-5.509738,"marketCap":139706059},{"date":"2024-09-27","current":-4.249491,"twenty":-5.950186,"median":-5.560665,"eighty":-5.486339,"marketCap":122463357},{"date":"2024-10-04","current":-5.056014,"twenty":-5.921282,"median":-5.540019,"eighty":-5.041842,"marketCap":145706004},{"date":"2024-10-11","current":-4.981461,"twenty":-5.86072,"median":-5.519373,"eighty":-4.824223,"marketCap":143557524},{"date":"2024-10-18","current":-4.920464,"twenty":-5.785018,"median":-5.512491,"eighty":-4.844556,"marketCap":141799677},{"date":"2024-10-25","current":-5.774428,"twenty":-5.765917,"median":-5.512491,"eighty":-4.844556,"marketCap":166409538},{"date":"2024-11-01","current":-5.306781,"twenty":-5.809795,"median":-5.512491,"eighty":-4.893354,"marketCap":152932709},{"date":"2024-11-08","current":-5.937088,"twenty":-5.927371,"median":-5.540019,"eighty":-4.957062,"marketCap":171097131},{"date":"2024-11-15","current":-5.958745,"twenty":-5.939799,"median":-5.550342,"eighty":-5.011034,"marketCap":169534600},{"date":"2024-11-22","current":-6.164693,"twenty":-5.973458,"median":-5.595075,"eighty":-5.037775,"marketCap":175394091},{"date":"2024-11-29","current":-5.581175,"twenty":-6.024512,"median":-5.608839,"eighty":-5.04517,"marketCap":158792200},{"date":"2024-12-06","current":-6.144098,"twenty":-6.055165,"median":-5.638088,"eighty":-5.051947,"marketCap":174808142},{"date":"2024-12-13","current":-5.917556,"twenty":-6.037784,"median":-5.643249,"eighty":-5.107523,"marketCap":168362702},{"date":"2024-12-20","current":-4.647547,"twenty":-6.017783,"median":-5.638088,"eighty":-5.04517,"marketCap":132229175},{"date":"2024-12-27","current":-6.068584,"twenty":-6.019156,"median":-5.638088,"eighty":-5.043814,"marketCap":172659662},{"date":"2025-01-03","current":-5.718473,"twenty":-6.013664,"median":-5.622603,"eighty":-5.049236,"marketCap":162698527},{"date":"2025-01-10","current":-5.697878,"twenty":-5.992612,"median":-5.622603,"eighty":-5.054658,"marketCap":162112578},{"date":"2025-01-17","current":-5.917556,"twenty":-5.969958,"median":-5.636367,"eighty":-5.146627,"marketCap":168362702},{"date":"2025-01-24","current":-6.940428,"twenty":-6.032033,"median":-5.643249,"eighty":-5.178584,"marketCap":197464839},{"date":"2025-01-31","current":-6.199017,"twenty":-6.064465,"median":-5.677284,"eighty":-5.209185,"marketCap":176370673},{"date":"2025-02-07","current":-6.047989,"twenty":-6.091559,"median":-5.691423,"eighty":-5.241176,"marketCap":172073713},{"date":"2025-02-14","current":-5.327173,"twenty":-6.072917,"median":-5.687582,"eighty":-5.255778,"marketCap":151565495},{"date":"2025-02-21","current":-5.279119,"twenty":-6.065838,"median":-5.658037,"eighty":-5.254405,"marketCap":150198280},{"date":"2025-02-28","current":-4.970198,"twenty":-6.060665,"median":-5.639808,"eighty":-5.174772,"marketCap":141409044},{"date":"2025-03-07","current":-4.771115,"twenty":-6.057666,"median":-5.608839,"eighty":-5.040292,"marketCap":135744870},{"date":"2025-03-14","current":-5.189762,"twenty":-6.053039,"median":-5.581175,"eighty":-5.033989,"marketCap":141604361},{"date":"2025-03-21","current":-4.831847,"twenty":-6.048768,"median":-5.560665,"eighty":-5.014488,"marketCap":131838543},{"date":"2025-03-28","current":-5.655051,"twenty":-6.042497,"median":-5.560665,"eighty":-5.033989,"marketCap":154299924},{"date":"2025-04-04","current":-4.932064,"twenty":-6.028767,"median":-5.540019,"eighty":-4.987939,"marketCap":134572972},{"date":"2025-04-11","current":-5.483252,"twenty":-6.017783,"median":-5.519391,"eighty":-4.984609,"marketCap":149612331},{"date":"2025-04-17","current":-5.726634,"twenty":-6.012291,"median":-5.540019,"eighty":-4.990995,"marketCap":156253088},{"date":"2025-04-25","current":-6.406672,"twenty":-6.045243,"median":-5.553757,"eighty":-4.998855,"marketCap":174808142},{"date":"2025-05-02","current":-7.537682,"twenty":-6.061192,"median":-5.567445,"eighty":-5.009067,"marketCap":205668127},{"date":"2025-05-09","current":-7.408833,"twenty":-6.107591,"median":-5.601957,"eighty":-5.032369,"marketCap":202152432},{"date":"2025-05-16","current":-8.179286,"twenty":-6.139979,"median":-5.636367,"eighty":-5.039569,"marketCap":206987413},{"date":"2025-05-23","current":-7.830407,"twenty":-6.178422,"median":-5.644452,"eighty":-5.043814,"marketCap":198158566},{"date":"2025-05-30","current":-8.194792,"twenty":-6.211408,"median":-5.662735,"eighty":-5.049236,"marketCap":207379806},{"date":"2025-06-06","current":-7.047366,"twenty":-6.281396,"median":-5.690843,"eighty":-5.056014,"marketCap":178342709},{"date":"2025-06-13","current":-6.675228,"twenty":-6.406672,"median":-5.69465,"eighty":-5.089546,"marketCap":168925272},{"date":"2025-06-20","current":-5.806906,"twenty":-6.42894,"median":-5.722554,"eighty":-5.141086,"marketCap":146951253},{"date":"2025-06-27","current":-4.512175,"twenty":-6.410449,"median":-5.697878,"eighty":-5.08284,"marketCap":114186421},{"date":"2025-07-03","current":-5.109147,"twenty":-6.389172,"median":-5.691014,"eighty":-5.046525,"marketCap":129293559},{"date":"2025-07-11","current":-4.791279,"twenty":-6.365148,"median":-5.677284,"eighty":-5.035608,"marketCap":121249498},{"date":"2025-07-18","current":-4.853302,"twenty":-6.320988,"median":-5.645656,"eighty":-4.991444,"marketCap":122819071},{"date":"2025-07-25","current":-5.419262,"twenty":-6.287654,"median":-5.638088,"eighty":-4.976956,"marketCap":137141423},{"date":"2025-08-01","current":-5.620836,"twenty":-6.265937,"median":-5.628589,"eighty":-4.986182,"marketCap":142242535},{"date":"2025-08-08","current":-6.527901,"twenty":-6.287654,"median":-5.632466,"eighty":-4.991444,"marketCap":165196967},{"date":"2025-08-15","current":-6.908485,"twenty":-6.414227,"median":-5.639808,"eighty":-4.995735,"marketCap":170525437},{"date":"2025-08-22","current":-6.442036,"twenty":-6.458702,"median":-5.650353,"eighty":-5.00125,"marketCap":159011858},{"date":"2025-08-29","current":-6.908485,"twenty":-6.483225,"median":-5.670419,"eighty":-5.019908,"marketCap":170525437},{"date":"2025-09-05","current":-7.328709,"twenty":-6.512404,"median":-5.690843,"eighty":-5.033989,"marketCap":180898030},{"date":"2025-09-12","current":-5.859066,"twenty":-6.574176,"median":-5.69465,"eighty":-5.040292,"marketCap":144622132},{"date":"2025-09-19","current":-6.375067,"twenty":-6.549229,"median":-5.726634,"eighty":-5.04517,"marketCap":157358843},{"date":"2025-09-26","current":-6.175411,"twenty":-6.549229,"median":-5.729418,"eighty":-5.051947,"marketCap":152430635},{"date":"2025-10-03","current":-6.212557,"twenty":-6.533707,"median":-5.754096,"eighty":-5.069427,"marketCap":153347511},{"date":"2025-10-10","current":-7.512643,"twenty":-6.537578,"median":-5.770478,"eighty":-5.097386,"marketCap":185438171},{"date":"2025-10-17","current":-7.24334,"twenty":-6.589924,"median":-5.79172,"eighty":-5.109147,"marketCap":178790820},{"date":"2025-10-24","current":-6.732591,"twenty":-6.670885,"median":-5.814177,"eighty":-5.112248,"marketCap":166183775},{"date":"2025-10-31","current":-6.110407,"twenty":-6.6744,"median":-5.859066,"eighty":-5.12,"marketCap":150826102},{"date":"2025-11-07","current":-5.785385,"twenty":-6.670885,"median":-5.869501,"eighty":-5.13638,"marketCap":142803437},{"date":"2025-11-14","current":-5.536933,"twenty":-6.66337,"median":-5.85039,"eighty":-5.154603,"marketCap":136670768},{"date":"2025-11-21","current":-5.868654,"twenty":-6.637844,"median":-5.836285,"eighty":-5.160645,"marketCap":141551867},{"date":"2025-11-28","current":-7.352682,"twenty":-6.647528,"median":-5.86386,"eighty":-5.168486,"marketCap":177346592},{"date":"2025-12-05","current":-7.082858,"twenty":-6.676544,"median":-5.869501,"eighty":-5.172026,"marketCap":170838460},{"date":"2025-12-12","current":-7.150314,"twenty":-6.706669,"median":-5.884194,"eighty":-5.183365,"marketCap":172465493},{"date":"2025-12-19","current":-6.764853,"twenty":-6.718803,"median":-5.896423,"eighty":-5.185781,"marketCap":163168162},{"date":"2025-12-26","current":-6.321572,"twenty":-6.721745,"median":-5.917556,"eighty":-5.189762,"marketCap":152476231},{"date":"2026-01-02","current":-5.897564,"twenty":-6.709975,"median":-5.917556,"eighty":-5.218313,"marketCap":142249167},{"date":"2026-01-09","current":-6.051748,"twenty":-6.706828,"median":-5.918043,"eighty":-5.231645,"marketCap":145968099},{"date":"2026-01-16","current":-5.12664,"twenty":-6.706347,"median":-5.916837,"eighty":-5.218313,"marketCap":123654504},{"date":"2026-01-23","current":-5.251915,"twenty":-6.701519,"median":-5.896423,"eighty":-5.230096,"marketCap":126676137},{"date":"2026-01-30","current":-4.567721,"twenty":-6.691045,"median":-5.884194,"eighty":-5.187481,"marketCap":110173374},{"date":"2026-02-06","current":-4.162986,"twenty":-6.680588,"median":-5.869501,"eighty":-5.163192,"marketCap":100411176},{"date":"2026-02-13","current":-4.085894,"twenty":-6.675886,"median":-5.86386,"eighty":-5.121593,"marketCap":98551710},{"date":"2026-02-20","current":-4.085894,"twenty":-6.6744,"median":-5.836285,"eighty":-5.109147,"marketCap":98551710},{"date":"2026-02-27","current":-3.806434,"twenty":-6.670885,"median":-5.810835,"eighty":-5.051947,"marketCap":91811145},{"date":"2026-03-06","current":-3.083693,"twenty":-6.66337,"median":-5.801368,"eighty":-5.014488,"marketCap":74378649},{"date":"2026-03-13","current":-2.457318,"twenty":-6.638594,"median":-5.7914,"eighty":-4.984609,"marketCap":59270486},{"date":"2026-03-20","current":-2.409136,"twenty":-6.610668,"median":-5.770478,"eighty":-4.925104,"marketCap":58108320},{"date":"2026-03-25","current":-2.129676,"twenty":-6.610668,"median":-5.760243,"eighty":-4.881955,"marketCap":51367754}],"updateTime":1774514810768},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"ACTU\",pageSize:20,pageCount:3,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"18394245","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924081632-ACTU","pdf_url":"","pub_time":1721707200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","symbol":"ACTU","title":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","titleType":"[Supp]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/0001104659-24-081632-index.htm","us_notice_code":"Form FWP","us_title_en":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"FWP","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp.htm","primary":true,"translateUrl":"","linkName":"tm247121d38_fwp.htm","type":"FWP","id":"NTFILECFrNntkXb3MLSpsE","market":"us","size":57097},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img001.jpg","type":"GRAPHIC","id":"NTFILEFJ4CKu9gTc57Kme9","market":"us","size":95799},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img002.jpg","type":"GRAPHIC","id":"NTFILEGXDwaM7KY8b3Lo7A","market":"us","size":179641},{"description":"GRAPHIC","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img003.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img003.jpg","type":"GRAPHIC","id":"NTFILE2fjZb3cz4ebdKbQM","market":"us","size":316974},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img004.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img004.jpg","type":"GRAPHIC","id":"NTFILE5HFLwyZ6RBfnkHuW","market":"us","size":93616},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img005.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img005.jpg","type":"GRAPHIC","id":"NTFILEAQZoQbZ9bAyHi5FD","market":"us","size":137176},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img006.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img006.jpg","type":"GRAPHIC","id":"NTFILE4CB9Luxzof5BA7GJ","market":"us","size":162106},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img007.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img007.jpg","type":"GRAPHIC","id":"NTFILE4Uzk2jWTdx8zw8Bx","market":"us","size":129651},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img008.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img008.jpg","type":"GRAPHIC","id":"NTFILEDZXkBNDGMF3JHdqM","market":"us","size":137900},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img009.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img009.jpg","type":"GRAPHIC","id":"NTFILEC51AdCwJqCzmMByp","market":"us","size":215232},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img010.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img010.jpg","type":"GRAPHIC","id":"NTFILEDKF4m9KvfyRcuskb","market":"us","size":141830},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img011.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img011.jpg","type":"GRAPHIC","id":"NTFILE4eh3SKAqaGu8BWq5","market":"us","size":152647},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img012.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img012.jpg","type":"GRAPHIC","id":"NTFILEApYNcUstPbdwLQA5","market":"us","size":112429},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img013.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img013.jpg","type":"GRAPHIC","id":"NTFILEC5XhWATiksxijxLQ","market":"us","size":108357},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img014.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img014.jpg","type":"GRAPHIC","id":"NTFILE53E3s5dHpt8nrUg8","market":"us","size":115149},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img015.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img015.jpg","type":"GRAPHIC","id":"NTFILEKrh2WsdNTVbpJ6tm","market":"us","size":159726},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img016.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img016.jpg","type":"GRAPHIC","id":"NTFILE4E46bMGRAcyTutev","market":"us","size":219589},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img017.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img017.jpg","type":"GRAPHIC","id":"NTFILEHecTLaRmgufiPWyb","market":"us","size":183326},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img018.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img018.jpg","type":"GRAPHIC","id":"NTFILE8uwhUqYUUbG1LqL9","market":"us","size":177371},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img019.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img019.jpg","type":"GRAPHIC","id":"NTFILE7ZQuFnSpFWuSCeTn","market":"us","size":192244},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img020.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img020.jpg","type":"GRAPHIC","id":"NTFILEB1uPd6DbwKqnR5mD","market":"us","size":183123},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img021.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img021.jpg","type":"GRAPHIC","id":"NTFILE2D3q5P7HSmA8fyRV","market":"us","size":165213},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img022.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img022.jpg","type":"GRAPHIC","id":"NTFILE7ayk33MBPqttB11M","market":"us","size":88119},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img023.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img023.jpg","type":"GRAPHIC","id":"NTFILE6Bb4JaXnQfaybUEY","market":"us","size":245917},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img024.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img024.jpg","type":"GRAPHIC","id":"NTFILE2shizVk2vA6V45gD","market":"us","size":93652},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img025.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img025.jpg","type":"GRAPHIC","id":"NTFILE8myS3sXjejG5aDw5","market":"us","size":227507},{"description":"GRAPHIC","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img026.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img026.jpg","type":"GRAPHIC","id":"NTFILE9VtbvTfQ6xXQ2hz5","market":"us","size":111216},{"description":"GRAPHIC","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081632/tm247121d38_fwp-img027.jpg","primary":false,"translateUrl":"","linkName":"tm247121d38_fwp-img027.jpg","type":"GRAPHIC","id":"NTFILEEx3KLwvXDKWrpY2i","market":"us","size":66546}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Supp]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Supp]Public Prospectus","pubTime":"2024-07-23 12:00","pubTimestamp":1721707200,"title_zh":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601114","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924081183-ACTU","pdf_url":"","pub_time":1721421744000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-081183-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081183/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILE7eY6ZVxAy1RdpRxz","market":"us","size":5880}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-20 04:42","pubTimestamp":1721421744,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601140","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924081181-ACTU","pdf_url":"","pub_time":1721421664000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-081181-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081181/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILE5phoTx9Gt7MH38eX","market":"us","size":6714}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-20 04:41","pubTimestamp":1721421664,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18387602","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924081013-ACTU","pdf_url":"","pub_time":1721361600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","symbol":"ACTU","title":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","titleType":"[Supp]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/0001104659-24-081013-index.htm","us_notice_code":"Form FWP","us_title_en":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"FWP","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwp.htm","primary":true,"translateUrl":"","linkName":"tm247121d32_fwp.htm","type":"FWP","id":"NTFILE8wtLGqNXuUQ9inxY","market":"us","size":48421},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg001.jpg","type":"GRAPHIC","id":"NTFILE6kE7j8W5uf7ggfFK","market":"us","size":92072},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg002.jpg","type":"GRAPHIC","id":"NTFILECTSyMXWG11KAQtVy","market":"us","size":168369},{"description":"GRAPHIC","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg003.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg003.jpg","type":"GRAPHIC","id":"NTFILE7JgbWtHHfBM1J4LX","market":"us","size":301884},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg004.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg004.jpg","type":"GRAPHIC","id":"NTFILEDJiLaWajPt8JyWpp","market":"us","size":87109},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg005.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg005.jpg","type":"GRAPHIC","id":"NTFILEFykuULcw2PPHo3NX","market":"us","size":130131},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg006.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg006.jpg","type":"GRAPHIC","id":"NTFILE4U7FvqcpHQcrwHZJ","market":"us","size":146955},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg007.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg007.jpg","type":"GRAPHIC","id":"NTFILE2JNMcXoZqjgLWUrP","market":"us","size":122629},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg008.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg008.jpg","type":"GRAPHIC","id":"NTFILE5zBwLbEx2HVSWvTC","market":"us","size":127596},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg009.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg009.jpg","type":"GRAPHIC","id":"NTFILEaZxXDHG3nFNWcGyT","market":"us","size":194951},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg010.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg010.jpg","type":"GRAPHIC","id":"NTFILE6CaHwzqhseNBtQzy","market":"us","size":130911},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg011.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg011.jpg","type":"GRAPHIC","id":"NTFILEExoN4Afju3UdwTZd","market":"us","size":138783},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg012.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg012.jpg","type":"GRAPHIC","id":"NTFILE4WKNUP2jS81fztbd","market":"us","size":92426},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg013.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg013.jpg","type":"GRAPHIC","id":"NTFILE4G5zLC5a4izKusJx","market":"us","size":92861},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg014.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg014.jpg","type":"GRAPHIC","id":"NTFILEBAW2gTHK2rsTfsyB","market":"us","size":102502},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg015.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg015.jpg","type":"GRAPHIC","id":"NTFILE5b2UFt3XCfkGjxx4","market":"us","size":145113},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg016.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg016.jpg","type":"GRAPHIC","id":"NTFILEGmqU7YSTWL687B5D","market":"us","size":207225},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg017.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg017.jpg","type":"GRAPHIC","id":"NTFILE4rC2TqjQaFFQn1KE","market":"us","size":169787},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg018.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg018.jpg","type":"GRAPHIC","id":"NTFILECSyraUjq5qS9ZJo6","market":"us","size":162166},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg019.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg019.jpg","type":"GRAPHIC","id":"NTFILE4ZN9UUoMHSeaYiUH","market":"us","size":173359},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg020.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg020.jpg","type":"GRAPHIC","id":"NTFILEC4JbpCAz4hTxtiWZ","market":"us","size":171590},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg021.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg021.jpg","type":"GRAPHIC","id":"NTFILEFN1j18EZEYsYyYXd","market":"us","size":146378},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg022.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg022.jpg","type":"GRAPHIC","id":"NTFILEGDvVvZ9jj5Gyra9F","market":"us","size":78109},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg023.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg023.jpg","type":"GRAPHIC","id":"NTFILEByyxLwLzYSi49kt2","market":"us","size":234986},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg024.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg024.jpg","type":"GRAPHIC","id":"NTFILEH3W4R9ywpuiP4D83","market":"us","size":87755},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg025.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg025.jpg","type":"GRAPHIC","id":"NTFILEAPbMCvHs2RsTqeQ8","market":"us","size":205703},{"description":"GRAPHIC","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg026.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg026.jpg","type":"GRAPHIC","id":"NTFILE5WvqoqzryH1EYSR3","market":"us","size":101158},{"description":"GRAPHIC","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081013/tm247121d32_fwpimg027.jpg","primary":false,"translateUrl":"","linkName":"tm247121d32_fwpimg027.jpg","type":"GRAPHIC","id":"NTFILEBBBbT7VpW3tHv3oq","market":"us","size":61717}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Supp]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Supp]Public Prospectus","pubTime":"2024-07-19 12:00","pubTimestamp":1721361600,"title_zh":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18387601","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924081008-ACTU","pdf_url":"","pub_time":1721361600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","symbol":"ACTU","title":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","titleType":"[Amend]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/0001104659-24-081008-index.htm","us_notice_code":"Form S-1/A","us_title_en":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"S-1/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121-28_s1a.htm","primary":true,"translateUrl":"","linkName":"tm247121-28_s1a.htm","type":"S-1/A","id":"NTFILEEWDZqEN4PKdrZcv6","market":"us","size":3591686},{"description":"EXHIBIT 1.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121d29_ex1-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d29_ex1-1.htm","type":"EX-1.1","id":"NTFILE2JPJWWyApArUwPze","market":"us","size":218323},{"description":"EXHIBIT 5.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121d29_ex5-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d29_ex5-1.htm","type":"EX-5.1","id":"NTFILEGGaV8bXvTNERcqg2","market":"us","size":7846},{"description":"EXHIBIT 23.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121d29_ex23-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d29_ex23-1.htm","type":"EX-23.1","id":"NTFILEADUZRo5A3GJaJeM6","market":"us","size":2389},{"description":"EX-FILING FEES","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121d29_ex-filingfees.htm","primary":false,"translateUrl":"","linkName":"tm247121d29_ex-filingfees.htm","type":"EX-FILING FEES","id":"NTFILEQNxgraaqo1yeAgJb","market":"us","size":18810},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_1801part-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part-4c.jpg","type":"GRAPHIC","id":"NTFILE92AtXEja3tkXJoKo","market":"us","size":89107},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_1801part2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part2-4c.jpg","type":"GRAPHIC","id":"NTFILE2wnSuDacE74YGSEU","market":"us","size":68096},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_1801part3b-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b-4c.jpg","type":"GRAPHIC","id":"NTFILE5Yp3JW3sH5K6oHDW","market":"us","size":50984},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_1801part3b2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b2-4c.jpg","type":"GRAPHIC","id":"NTFILEHvDWGzK73zi2kf68","market":"us","size":58473},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_8moverl-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_8moverl-4c.jpg","type":"GRAPHIC","id":"NTFILEAY1c6nro5dwGPKzw","market":"us","size":85624},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_alive-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_alive-4c.jpg","type":"GRAPHIC","id":"NTFILE7P1xf6oYpcahxFaa","market":"us","size":72968},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_overallsurvi-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_overallsurvi-4c.jpg","type":"GRAPHIC","id":"NTFILEDEb7pCeojeY8s9oY","market":"us","size":82204},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_partial-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_partial-4c.jpg","type":"GRAPHIC","id":"NTFILE2RimT63xJZxDvDLK","market":"us","size":66295},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/bc_stable-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_stable-4c.jpg","type":"GRAPHIC","id":"NTFILE31VQDryNKLKVRwzi","market":"us","size":67129},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/fc_clinistud-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_clinistud-4c.jpg","type":"GRAPHIC","id":"NTFILECps3NBSZixS7P1WP","market":"us","size":89173},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/fc_multimoa-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_multimoa-4c.jpg","type":"GRAPHIC","id":"NTFILE73S5JTmGAxm9wFRr","market":"us","size":92226},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/fc_tcellnk-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_tcellnk-4c.jpg","type":"GRAPHIC","id":"NTFILE6i7mU7NHaaScdG5S","market":"us","size":106432},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/lc_elraglarit-4clr.jpg","primary":false,"translateUrl":"","linkName":"lc_elraglarit-4clr.jpg","type":"GRAPHIC","id":"NTFILE5NgaRSJVJ2DYLWEw","market":"us","size":41185},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/lc_elrainje-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_elrainje-4c.jpg","type":"GRAPHIC","id":"NTFILEBz397AY5mHR5qvVr","market":"us","size":54636},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/lc_gnp-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_gnp-4c.jpg","type":"GRAPHIC","id":"NTFILE4KCsNym4sik68dqd","market":"us","size":78483},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/lg_actuatetherape-4clr.jpg","primary":false,"translateUrl":"","linkName":"lg_actuatetherape-4clr.jpg","type":"GRAPHIC","id":"NTFILE6exp9DwVxDhu9r4J","market":"us","size":9987},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/ph_mri12week-bw.jpg","primary":false,"translateUrl":"","linkName":"ph_mri12week-bw.jpg","type":"GRAPHIC","id":"NTFILE2R8A4FbRrBNDz2oK","market":"us","size":155512},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_adverseevent-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_adverseevent-4c.jpg","type":"GRAPHIC","id":"NTFILE8C9F3Nso1REhei7Q","market":"us","size":113661},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_anatomical-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_anatomical-4c.jpg","type":"GRAPHIC","id":"NTFILEFzDKiJuCTFdg6fnH","market":"us","size":33613},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_demographics-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_demographics-4c.jpg","type":"GRAPHIC","id":"NTFILE29Mou2dknZnFrDxC","market":"us","size":142867},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_elraglusib-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_elraglusib-4c.jpg","type":"GRAPHIC","id":"NTFILE4GLcoMJv4RtMZtUc","market":"us","size":112050},{"description":"GRAPHIC","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_general-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_general-4c.jpg","type":"GRAPHIC","id":"NTFILEEUsYnAUenjMgEsr7","market":"us","size":55206},{"description":"GRAPHIC","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_patients-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_patients-4c.jpg","type":"GRAPHIC","id":"NTFILEFCjWrMxFTNJw44Fw","market":"us","size":114028},{"description":"GRAPHIC","seq":29,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tb_route-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_route-4c.jpg","type":"GRAPHIC","id":"NTFILEbkkzmcbFdo31Uj2d","market":"us","size":21300},{"description":"GRAPHIC","seq":30,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924081008/tm247121d29_ex5-1img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d29_ex5-1img001.jpg","type":"GRAPHIC","id":"NTFILEGhfXZn42Et3sqwZR","market":"us","size":13735}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Amend]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Amend]Public Prospectus","pubTime":"2024-07-19 12:00","pubTimestamp":1721361600,"title_zh":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601211","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924080518-ACTU","pdf_url":"","pub_time":1721240985000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-080518-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080518/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEC5zEohuKHwP96rBH","market":"us","size":5616}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-18 02:29","pubTimestamp":1721240985,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601204","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924080516-ACTU","pdf_url":"","pub_time":1721240950000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-080516-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080516/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILE4PWtEnbdSZouLS7D","market":"us","size":5431}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-18 02:29","pubTimestamp":1721240950,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18376962","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924080179-ACTU","pdf_url":"","pub_time":1721102400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","symbol":"ACTU","title":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","titleType":"[Amend]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/0001104659-24-080179-index.htm","us_notice_code":"Form S-1/A","us_title_en":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"S-1/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tm247121-23_s1a.htm","primary":true,"translateUrl":"","linkName":"tm247121-23_s1a.htm","type":"S-1/A","id":"NTFILE5tUVbMyWUxe9QDCK","market":"us","size":3574779},{"description":"EXHIBIT 10.4","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tm247121d24_ex10-4.htm","primary":false,"translateUrl":"","linkName":"tm247121d24_ex10-4.htm","type":"EX-10.4","id":"NTFILE81gabH1MzhnkwDgA","market":"us","size":223427},{"description":"EXHIBIT 23.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tm247121d24_ex23-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d24_ex23-1.htm","type":"EX-23.1","id":"NTFILECTTBXbgxj1dxEJRE","market":"us","size":2390},{"description":"GRAPHIC","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/lg_actuatetherape-4clr.jpg","primary":false,"translateUrl":"","linkName":"lg_actuatetherape-4clr.jpg","type":"GRAPHIC","id":"NTFILE6axAmiafymRPX88c","market":"us","size":9987},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/fc_multimoa-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_multimoa-4c.jpg","type":"GRAPHIC","id":"NTFILEBnyoZw8tSomvofxB","market":"us","size":94401},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/lc_elraglarit-4clr.jpg","primary":false,"translateUrl":"","linkName":"lc_elraglarit-4clr.jpg","type":"GRAPHIC","id":"NTFILEHxnBL6MwsvRsBQqa","market":"us","size":41185},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tb_route-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_route-4c.jpg","type":"GRAPHIC","id":"NTFILEEAcxyt4PjPHuToQV","market":"us","size":21300},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/fc_tcellnk-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_tcellnk-4c.jpg","type":"GRAPHIC","id":"NTFILEqwEz1p6bkLBoXFv3","market":"us","size":106432},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/fc_clinistud-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_clinistud-4c.jpg","type":"GRAPHIC","id":"NTFILE9E9jhz4CFSsJPRkQ","market":"us","size":89173},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_1801part-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part-4c.jpg","type":"GRAPHIC","id":"NTFILE3dysoui3iCix7xUV","market":"us","size":89107},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_overallsurvi-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_overallsurvi-4c.jpg","type":"GRAPHIC","id":"NTFILEFU8y7y4NkVrCTjtF","market":"us","size":82204},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tb_adverseevent-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_adverseevent-4c.jpg","type":"GRAPHIC","id":"NTFILE6ua2nQMo14h1VfEE","market":"us","size":113661},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_1801part2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part2-4c.jpg","type":"GRAPHIC","id":"NTFILE3bM1uAPQMAdxibkG","market":"us","size":68096},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/ph_mri12week-bw.jpg","primary":false,"translateUrl":"","linkName":"ph_mri12week-bw.jpg","type":"GRAPHIC","id":"NTFILEDCG4R6MVUmXFGWoq","market":"us","size":155512},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/lc_elrainje-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_elrainje-4c.jpg","type":"GRAPHIC","id":"NTFILE7xCJBurkbJLcWLYt","market":"us","size":54636},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_8moverl-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_8moverl-4c.jpg","type":"GRAPHIC","id":"NTFILEHGjAVJTNCkvggs2Y","market":"us","size":85624},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/lc_gnp-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_gnp-4c.jpg","type":"GRAPHIC","id":"NTFILEDGhzGQqasjsPWh6H","market":"us","size":78483},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_1801part3b-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b-4c.jpg","type":"GRAPHIC","id":"NTFILE9Aaf1YNwUtpCoeB8","market":"us","size":50984},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/bc_1801part3b2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b2-4c.jpg","type":"GRAPHIC","id":"NTFILE8vUcUtgZPS7kT2NT","market":"us","size":58473},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tb_elraglusib-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_elraglusib-4c.jpg","type":"GRAPHIC","id":"NTFILE72frsmHKeX2JELSS","market":"us","size":112050},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tb_patients-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_patients-4c.jpg","type":"GRAPHIC","id":"NTFILE2cKbStBrkVbbBPMm","market":"us","size":114028},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924080179/tm247121d24_ex10-4img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d24_ex10-4img001.jpg","type":"GRAPHIC","id":"NTFILE56tZW5T9RP33VEcT","market":"us","size":4448}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Amend]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Amend]Public Prospectus","pubTime":"2024-07-16 12:00","pubTimestamp":1721102400,"title_zh":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601165","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924079976-ACTU","pdf_url":"","pub_time":1721095017000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-079976-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924079976/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEG4SvyEYcL6PoBdhQ","market":"us","size":6373}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-16 09:56","pubTimestamp":1721095017,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601110","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924079975-ACTU","pdf_url":"","pub_time":1721094986000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-079975-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924079975/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEGWUUdFrugiRmLB9h","market":"us","size":6482}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-07-16 09:56","pubTimestamp":1721094986,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601126","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924073849-ACTU","pdf_url":"","pub_time":1718988572000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-073849-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073849/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEHPsxPbLXgaK7Ln1h","market":"us","size":10223},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073849/tm247121d21_correspimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d21_correspimg001.jpg","type":"GRAPHIC","id":"NTFILE8WbMB7Ri5hsj3G3X","market":"us","size":18601},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073849/tm247121d21_correspimg002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d21_correspimg002.jpg","type":"GRAPHIC","id":"NTFILECNz51rHRLKsTJbd7","market":"us","size":18958}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-06-22 00:49","pubTimestamp":1718988572,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18297234","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924073990-ACTU","pdf_url":"","pub_time":1718942400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","symbol":"ACTU","title":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","titleType":"[Supp]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/0001104659-24-073990-index.htm","us_notice_code":"Form FWP","us_title_en":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"FWP","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwp.htm","primary":true,"translateUrl":"","linkName":"tm247121d22_fwp.htm","type":"FWP","id":"NTFILE97M6NpBZfuYBcer2","market":"us","size":45701},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg001.jpg","type":"GRAPHIC","id":"NTFILE61Aj8HPQwNRQXgbx","market":"us","size":499715},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg002.jpg","type":"GRAPHIC","id":"NTFILE338gYcWPhiiPvZiz","market":"us","size":757535},{"description":"GRAPHIC","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg003.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg003.jpg","type":"GRAPHIC","id":"NTFILE6E1NYfzXVLKD5azx","market":"us","size":1388815},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg004.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg004.jpg","type":"GRAPHIC","id":"NTFILEFpi5kzHtZ3eUhRFc","market":"us","size":355629},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg005.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg005.jpg","type":"GRAPHIC","id":"NTFILE6upvdBrd3k4jcEGV","market":"us","size":616320},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg006.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg006.jpg","type":"GRAPHIC","id":"NTFILEHaPpoGdMjCk2hq1e","market":"us","size":678157},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg007.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg007.jpg","type":"GRAPHIC","id":"NTFILECcK2RXhWnxo8CgSm","market":"us","size":520738},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg008.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg008.jpg","type":"GRAPHIC","id":"NTFILE7Y16mZWYgdUmwasX","market":"us","size":536352},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg009.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg009.jpg","type":"GRAPHIC","id":"NTFILEDxwhih4gM54AZYex","market":"us","size":846636},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg010.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg010.jpg","type":"GRAPHIC","id":"NTFILE2sv2uBPn8pgKoZSL","market":"us","size":569081},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg011.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg011.jpg","type":"GRAPHIC","id":"NTFILEHhkXkxr8JL1Tc267","market":"us","size":594712},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg012.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg012.jpg","type":"GRAPHIC","id":"NTFILEHurhEjzT1z7SMUxn","market":"us","size":408904},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg013.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg013.jpg","type":"GRAPHIC","id":"NTFILEF7QMsffABoUhTzwu","market":"us","size":959880},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg014.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg014.jpg","type":"GRAPHIC","id":"NTFILE2VQDWtiDfdDVRrkP","market":"us","size":753903},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg015.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg015.jpg","type":"GRAPHIC","id":"NTFILEGg2TJS2RsrA8CAR6","market":"us","size":753464},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg016.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg016.jpg","type":"GRAPHIC","id":"NTFILEFvQgwpLj54kaMacj","market":"us","size":755637},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg017.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg017.jpg","type":"GRAPHIC","id":"NTFILE2zdPKjxRDw3XmiKX","market":"us","size":744152},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg018.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg018.jpg","type":"GRAPHIC","id":"NTFILE3efQ1EcewHaAYceZ","market":"us","size":641444},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg019.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg019.jpg","type":"GRAPHIC","id":"NTFILE9VgLQSCBPAJWNGg6","market":"us","size":338984},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg020.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg020.jpg","type":"GRAPHIC","id":"NTFILE3FLpMyBZuTDdhddx","market":"us","size":284683},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg021.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg021.jpg","type":"GRAPHIC","id":"NTFILE3teauwZrLeUgm5PC","market":"us","size":1030909},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg022.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg022.jpg","type":"GRAPHIC","id":"NTFILEH4uGg9AUrsdggQew","market":"us","size":384149},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg023.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg023.jpg","type":"GRAPHIC","id":"NTFILE5p59vpARybMV6m1t","market":"us","size":921197},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg024.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg024.jpg","type":"GRAPHIC","id":"NTFILEDguumaXAcAHKoqKD","market":"us","size":452496},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073990/tm247121d22_fwpimg025.jpg","primary":false,"translateUrl":"","linkName":"tm247121d22_fwpimg025.jpg","type":"GRAPHIC","id":"NTFILED7PTYTkP7MNpr7gf","market":"us","size":349011}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Supp]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Supp]Public Prospectus","pubTime":"2024-06-21 12:00","pubTimestamp":1718942400,"title_zh":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18296248","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924073848-ACTU","pdf_url":"","pub_time":1718942400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","symbol":"ACTU","title":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","titleType":"[Amend]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/0001104659-24-073848-index.htm","us_notice_code":"Form S-1/A","us_title_en":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"S-1/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tm247121-19_s1a.htm","primary":true,"translateUrl":"","linkName":"tm247121-19_s1a.htm","type":"S-1/A","id":"NTFILECES1W2fCRU9adk2J","market":"us","size":3574695},{"description":"EXHIBIT 1.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tm247121d20_ex1-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d20_ex1-1.htm","type":"EX-1.1","id":"NTFILE4kKjdyiypnS1TJsS","market":"us","size":221640},{"description":"EXHIBIT 10.3","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tm247121d19_ex10-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d19_ex10-3.htm","type":"EX-10.3","id":"NTFILE14odLs2htgPJuXpP","market":"us","size":20196},{"description":"EXHIBIT 23.1","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tm247121d19_ex23-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d19_ex23-1.htm","type":"EX-23.1","id":"NTFILEFjyEy3APYXH86Yea","market":"us","size":2388},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/lg_actuatetherape-4clr.jpg","primary":false,"translateUrl":"","linkName":"lg_actuatetherape-4clr.jpg","type":"GRAPHIC","id":"NTFILEH4sKNbRgjonddQqV","market":"us","size":9987},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/fc_multimoa-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_multimoa-4c.jpg","type":"GRAPHIC","id":"NTFILECPnaBvEt1FepFTGg","market":"us","size":94401},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/lc_elraglarit-4clr.jpg","primary":false,"translateUrl":"","linkName":"lc_elraglarit-4clr.jpg","type":"GRAPHIC","id":"NTFILEB3wR7m7tEY5WVSWj","market":"us","size":41185},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tb_route-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_route-4c.jpg","type":"GRAPHIC","id":"NTFILEANtPcdagsVYNDXaq","market":"us","size":21300},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/fc_tcellnk-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_tcellnk-4c.jpg","type":"GRAPHIC","id":"NTFILEELC3jp3ZCLxKZoyw","market":"us","size":106432},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/fc_clinistud-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_clinistud-4c.jpg","type":"GRAPHIC","id":"NTFILE3f35VKsL4AxpgVmM","market":"us","size":89173},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_1801part-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part-4c.jpg","type":"GRAPHIC","id":"NTFILE6Erks7EFzfGtRqYy","market":"us","size":89107},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_overallsurvi-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_overallsurvi-4c.jpg","type":"GRAPHIC","id":"NTFILEHkxgKrowwqjtPNTD","market":"us","size":82204},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tb_adverseevent-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_adverseevent-4c.jpg","type":"GRAPHIC","id":"NTFILEAK7B3kuy26g9VnCX","market":"us","size":113661},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_1801part2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part2-4c.jpg","type":"GRAPHIC","id":"NTFILEHpUu7oVPo3o3p9SE","market":"us","size":68096},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/ph_mri12week-bw.jpg","primary":false,"translateUrl":"","linkName":"ph_mri12week-bw.jpg","type":"GRAPHIC","id":"NTFILECXduKikZvTcgJ84t","market":"us","size":155512},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/lc_elrainje-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_elrainje-4c.jpg","type":"GRAPHIC","id":"NTFILE4wzdmzxAZenyUSQv","market":"us","size":54636},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_8moverl-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_8moverl-4c.jpg","type":"GRAPHIC","id":"NTFILEGLmv32RyWVruvWcm","market":"us","size":85624},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/lc_gnp-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_gnp-4c.jpg","type":"GRAPHIC","id":"NTFILE96N23EiAzh2X5kFS","market":"us","size":78483},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_1801part3b-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b-4c.jpg","type":"GRAPHIC","id":"NTFILE7tzJtsjLcUK9iNP2","market":"us","size":50984},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/bc_1801part3b2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b2-4c.jpg","type":"GRAPHIC","id":"NTFILE7CT9X5tPEwV1M3sS","market":"us","size":58473},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tb_elraglusib-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_elraglusib-4c.jpg","type":"GRAPHIC","id":"NTFILE8UfkCJNizEXv5iuc","market":"us","size":112050},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924073848/tb_patients-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_patients-4c.jpg","type":"GRAPHIC","id":"NTFILE4A1MkxHRz3wrejxD","market":"us","size":114028}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Amend]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Amend]Public Prospectus","pubTime":"2024-06-21 12:00","pubTimestamp":1718942400,"title_zh":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601132","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924070186-ACTU","pdf_url":"","pub_time":1718103659000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-070186-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070186/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEGnXaVPjVQ1GGe5Pd","market":"us","size":8332},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070186/tm247121d17_correspimg001.gif","primary":false,"translateUrl":"","linkName":"tm247121d17_correspimg001.gif","type":"GRAPHIC","id":"NTFILE4x2cE1XGJKUfkYPt","market":"us","size":6926},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070186/tm247121d17_correspimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d17_correspimg001.jpg","type":"GRAPHIC","id":"NTFILEGBNemx2AXcL2Xgx8","market":"us","size":4685}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-06-11 19:00","pubTimestamp":1718103659,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18257851","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924070197-ACTU","pdf_url":"","pub_time":1718078400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","symbol":"ACTU","title":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","titleType":"[Supp]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/0001104659-24-070197-index.htm","us_notice_code":"Form FWP","us_title_en":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"FWP","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwp.htm","primary":true,"translateUrl":"","linkName":"tm247121d18_fwp.htm","type":"FWP","id":"NTFILExi3gSCUt9qoG3GbN","market":"us","size":45539},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg001.jpg","type":"GRAPHIC","id":"NTFILE5MFBijz4QMtacLhS","market":"us","size":232439},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg002.jpg","type":"GRAPHIC","id":"NTFILE5HoWYYqvtDy9UVjx","market":"us","size":206257},{"description":"GRAPHIC","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg003.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg003.jpg","type":"GRAPHIC","id":"NTFILEBaBMxoDcZ9DQrPGK","market":"us","size":362099},{"description":"GRAPHIC","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg004.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg004.jpg","type":"GRAPHIC","id":"NTFILEGid6yc8SU37TSvoX","market":"us","size":103993},{"description":"GRAPHIC","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg005.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg005.jpg","type":"GRAPHIC","id":"NTFILEHgt98KmwAQkSHJuM","market":"us","size":145515},{"description":"GRAPHIC","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg006.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg006.jpg","type":"GRAPHIC","id":"NTFILE2DTFZz7iQMBBhoqZ","market":"us","size":172401},{"description":"GRAPHIC","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg007.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg007.jpg","type":"GRAPHIC","id":"NTFILEY8xHccT197hp8nuk","market":"us","size":144029},{"description":"GRAPHIC","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg008.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg008.jpg","type":"GRAPHIC","id":"NTFILE64FfAZRbEnbnwJh7","market":"us","size":149730},{"description":"GRAPHIC","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg009.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg009.jpg","type":"GRAPHIC","id":"NTFILE12qSibEPuA2LGpme","market":"us","size":233637},{"description":"GRAPHIC","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg010.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg010.jpg","type":"GRAPHIC","id":"NTFILE9Adda42GUdDs8ULu","market":"us","size":154173},{"description":"GRAPHIC","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg011.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg011.jpg","type":"GRAPHIC","id":"NTFILEF514F2jD6GVnX4rM","market":"us","size":169404},{"description":"GRAPHIC","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg012.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg012.jpg","type":"GRAPHIC","id":"NTFILE8oLTbb84AxvBLZu4","market":"us","size":109974},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg013.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg013.jpg","type":"GRAPHIC","id":"NTFILE6m6Y9Nnhh2gydN8D","market":"us","size":246688},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg014.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg014.jpg","type":"GRAPHIC","id":"NTFILE6FT3HQN5mFocR9fJ","market":"us","size":202081},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg015.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg015.jpg","type":"GRAPHIC","id":"NTFILE6d4Tw112BXebaT7b","market":"us","size":203602},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg016.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg016.jpg","type":"GRAPHIC","id":"NTFILEJ7wwbKmMkjseUeRP","market":"us","size":200674},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg017.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg017.jpg","type":"GRAPHIC","id":"NTFILE2uBVaPvv7uN91eeS","market":"us","size":202196},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg018.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg018.jpg","type":"GRAPHIC","id":"NTFILEHZcNRWF8zu92q3Ez","market":"us","size":178318},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg019.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg019.jpg","type":"GRAPHIC","id":"NTFILE8c2moSdEPUz5Q4K2","market":"us","size":97195},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg020.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg020.jpg","type":"GRAPHIC","id":"NTFILE2k346MKdVhr1EzrW","market":"us","size":82182},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg021.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg021.jpg","type":"GRAPHIC","id":"NTFILE6EJnwD81twtA5e6g","market":"us","size":284845},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg022.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg022.jpg","type":"GRAPHIC","id":"NTFILE4rJwrNLtESWEAgP5","market":"us","size":104233},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg023.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg023.jpg","type":"GRAPHIC","id":"NTFILEBXNRru9o3UQminHA","market":"us","size":252735},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg024.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg024.jpg","type":"GRAPHIC","id":"NTFILEHbqWgRME9WidU5Dq","market":"us","size":119888},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070197/tm247121d18_fwpimg025.jpg","primary":false,"translateUrl":"","linkName":"tm247121d18_fwpimg025.jpg","type":"GRAPHIC","id":"NTFILE8JF1Ue6umQANaNGE","market":"us","size":69474}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Supp]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Supp]Public Prospectus","pubTime":"2024-06-11 12:00","pubTimestamp":1718078400,"title_zh":"Form FWP - Filing under Securities Act Rules 163/433 of free writing prospectuses","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18257734","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924070185-ACTU","pdf_url":"","pub_time":1718078400000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","symbol":"ACTU","title":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","titleType":"[Amend]Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/0001104659-24-070185-index.htm","us_notice_code":"Form S-1/A","us_title_en":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend]","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"S-1/A","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121-15_s1a.htm","primary":true,"translateUrl":"","linkName":"tm247121-15_s1a.htm","type":"S-1/A","id":"NTFILE3wbEAyBs5Cirq1kU","market":"us","size":3589406},{"description":"EXHIBIT 3.2","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex3-2.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex3-2.htm","type":"EX-3.2","id":"NTFILEHQd4ayUVK8d9NatF","market":"us","size":11539},{"description":"EXHIBIT 4.1","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-1.htm","type":"EX-4.1","id":"NTFILE21Aoeown1CJRFH5S","market":"us","size":5095},{"description":"EXHIBIT 4.3","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-3.htm","type":"EX-4.3","id":"NTFILE7tj2A8m61xqDowKx","market":"us","size":96253},{"description":"EXHIBIT 4.4","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-4.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-4.htm","type":"EX-4.4","id":"NTFILE88RzyxrACvtNpcZt","market":"us","size":74835},{"description":"EXHIBIT 4.5","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-5.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-5.htm","type":"EX-4.5","id":"NTFILE8WQsTzitTtjWbkTM","market":"us","size":68708},{"description":"EXHIBIT 5.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex5-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex5-1.htm","type":"EX-5.1","id":"NTFILEHw2kbhkDQwcFV83C","market":"us","size":7851},{"description":"EXHIBIT 10.3","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex10-3.htm","type":"EX-10.3","id":"NTFILE7gC7LDHPaP5H2k38","market":"us","size":20195},{"description":"EXHIBIT 10.6","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-6.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex10-6.htm","type":"EX-10.6","id":"NTFILECFAejSLcgTsamgxo","market":"us","size":277021},{"description":"EXHIBIT 10.13","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-13.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex10-13.htm","type":"EX-10.13","id":"NTFILE2kA9jqmkUc8JUjZ5","market":"us","size":46457},{"description":"EXHIBIT 10.14","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex10-14.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex10-14.htm","type":"EX-10.14","id":"NTFILE6mveDpDJrAmgs3re","market":"us","size":37911},{"description":"EXHIBIT 23.1","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex23-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex23-1.htm","type":"EX-23.1","id":"NTFILE6CsyEAcVpJcn4ZV3","market":"us","size":2389},{"description":"EX-FILING FEES","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex-filingfees.htm","primary":false,"translateUrl":"","linkName":"tm247121d16_ex-filingfees.htm","type":"EX-FILING FEES","id":"NTFILEFYDoPwWDWD2Hvf5S","market":"us","size":15545},{"description":"GRAPHIC","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/lg_actuatetherape-4clr.jpg","primary":false,"translateUrl":"","linkName":"lg_actuatetherape-4clr.jpg","type":"GRAPHIC","id":"NTFILECzbGsBmUgUZMCZEF","market":"us","size":9987},{"description":"GRAPHIC","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/fc_multimoa-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_multimoa-4c.jpg","type":"GRAPHIC","id":"NTFILE34585ViWyWqm8R6v","market":"us","size":94401},{"description":"GRAPHIC","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/lc_elraglarit-4clr.jpg","primary":false,"translateUrl":"","linkName":"lc_elraglarit-4clr.jpg","type":"GRAPHIC","id":"NTFILEBoMUVE5VWBR8Ke2U","market":"us","size":41185},{"description":"GRAPHIC","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tb_route-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_route-4c.jpg","type":"GRAPHIC","id":"NTFILEGz85zEfWSoQLYUC2","market":"us","size":21300},{"description":"GRAPHIC","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/fc_tcellnk-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_tcellnk-4c.jpg","type":"GRAPHIC","id":"NTFILE77KSuqpq6xRtg4Rs","market":"us","size":106432},{"description":"GRAPHIC","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/fc_clinistud-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_clinistud-4c.jpg","type":"GRAPHIC","id":"NTFILE6e6cYK6bgMPRfqnE","market":"us","size":89173},{"description":"GRAPHIC","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_1801part-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part-4c.jpg","type":"GRAPHIC","id":"NTFILE5Jd9UKxbwsCXfs1L","market":"us","size":89107},{"description":"GRAPHIC","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_overallsurvi-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_overallsurvi-4c.jpg","type":"GRAPHIC","id":"NTFILEGNuKKvba3tKT7R4f","market":"us","size":82204},{"description":"GRAPHIC","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tb_adverseevent-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_adverseevent-4c.jpg","type":"GRAPHIC","id":"NTFILEA33SNMij5r6BTBiz","market":"us","size":113661},{"description":"GRAPHIC","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_1801part2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part2-4c.jpg","type":"GRAPHIC","id":"NTFILECH1shL2HP2AYCKpq","market":"us","size":68096},{"description":"GRAPHIC","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/ph_mri12week-bw.jpg","primary":false,"translateUrl":"","linkName":"ph_mri12week-bw.jpg","type":"GRAPHIC","id":"NTFILEC61DSqD1HFWefeP9","market":"us","size":155512},{"description":"GRAPHIC","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/lc_elrainje-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_elrainje-4c.jpg","type":"GRAPHIC","id":"NTFILEBuh5S8S8pEKBidrs","market":"us","size":54636},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_8moverl-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_8moverl-4c.jpg","type":"GRAPHIC","id":"NTFILEEwEady8P1pPcjMe3","market":"us","size":85624},{"description":"GRAPHIC","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/lc_gnp-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_gnp-4c.jpg","type":"GRAPHIC","id":"NTFILEGV2BX5okDoSc5gWV","market":"us","size":78483},{"description":"GRAPHIC","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_1801part3b-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b-4c.jpg","type":"GRAPHIC","id":"NTFILE5ykyk5P8gKvujLfY","market":"us","size":50984},{"description":"GRAPHIC","seq":29,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/bc_1801part3b2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b2-4c.jpg","type":"GRAPHIC","id":"NTFILEjvppDbGokdZf1sqJ","market":"us","size":58473},{"description":"GRAPHIC","seq":30,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tb_elraglusib-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_elraglusib-4c.jpg","type":"GRAPHIC","id":"NTFILECRncAbMix9u6DTv1","market":"us","size":112050},{"description":"GRAPHIC","seq":31,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tb_patients-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_patients-4c.jpg","type":"GRAPHIC","id":"NTFILEDQrCTJVJL1wwj12N","market":"us","size":114028},{"description":"GRAPHIC","seq":32,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-1img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-1img001.jpg","type":"GRAPHIC","id":"NTFILEF4XcB8T11LiC6Dga","market":"us","size":657422},{"description":"GRAPHIC","seq":33,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-1img002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-1img002.jpg","type":"GRAPHIC","id":"NTFILEAT9kyLEWiw6samy5","market":"us","size":131386},{"description":"GRAPHIC","seq":34,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-4img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-4img001.jpg","type":"GRAPHIC","id":"NTFILEAKyxZ4Ga41suPZAC","market":"us","size":1857},{"description":"GRAPHIC","seq":35,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex4-5img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d16_ex4-5img001.jpg","type":"GRAPHIC","id":"NTFILEAwhYdKgjmVP7gyHY","market":"us","size":1857},{"description":"GRAPHIC","seq":36,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924070185/tm247121d16_ex5-1img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d16_ex5-1img001.jpg","type":"GRAPHIC","id":"NTFILE9STt9AYrwxpm1DMx","market":"us","size":13735}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"[Amend]Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"[Amend]Public Prospectus","pubTime":"2024-06-11 12:00","pubTimestamp":1718078400,"title_zh":"Form S-1/A - General form for registration of securities under the Securities Act of 1933: [Amend","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18601119","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924065178-ACTU","pdf_url":"","pub_time":1716584544000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form CORRESP - Correspondence","symbol":"ACTU","title":"Form CORRESP - Correspondence","titleType":"Correspondence","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/1652935/0001104659-24-065178-index.html","us_notice_code":"Form CORRESP","us_title_en":"Form CORRESP - Correspondence","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065178/filename1.htm","primary":true,"translateUrl":"","linkName":"filename1.htm","type":"CORRESP","id":"NTFILEJC1vXHLGCuLv3hk7","market":"us","size":8476},{"description":"GRAPHIC","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065178/tm247121d14_correspimg001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d14_correspimg001.jpg","type":"GRAPHIC","id":"NTFILECArRzcSEC97tGEdL","market":"us","size":6457},{"description":"GRAPHIC","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065178/tm247121d14_correspimg002.jpg","primary":false,"translateUrl":"","linkName":"tm247121d14_correspimg002.jpg","type":"GRAPHIC","id":"NTFILE4BgS3Zz7ngkFBRxK","market":"us","size":6236}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Correspondence","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Correspondence","pubTime":"2024-05-25 05:02","pubTimestamp":1716584544,"title_zh":"Form CORRESP - Correspondence","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"18257726","market":"us","labels":[],"media":"sec.gov","original_id":"AN110465924065172-ACTU","pdf_url":"","pub_time":1716523200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form S-1 - General form for registration of securities under the Securities Act of 1933","symbol":"ACTU","title":"Form S-1 - General form for registration of securities under the Securities Act of 1933","titleType":"Public Prospectus","type":"usProspectusesRegistrations","url":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/0001104659-24-065172-index.htm","us_notice_code":"Form S-1","us_title_en":"Form S-1 - General form for registration of securities under the Securities Act of 1933","is_important":0,"hasEarnInfos":false,"gpt_zh_title":null,"gpt_en_title":null,"attachments":[{"description":"S-1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121-12_s1.htm","primary":true,"translateUrl":"","linkName":"tm247121-12_s1.htm","type":"S-1","id":"NTFILEBnzTWAXnZSLhaoaV","market":"us","size":3548170},{"description":"EXHIBIT 3.1","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex3-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex3-1.htm","type":"EX-3.1","id":"NTFILECpL7NRrR4Gqqy71C","market":"us","size":161403},{"description":"EXHIBIT 3.3","seq":3,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex3-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex3-3.htm","type":"EX-3.3","id":"NTFILEFiLMrkCAR8Dxmqtf","market":"us","size":43385},{"description":"EXHIBIT 3.4","seq":4,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex3-4.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex3-4.htm","type":"EX-3.4","id":"NTFILED6PF9FdQ5swMW6uT","market":"us","size":84099},{"description":"EXHIBIT 3.5","seq":5,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex3-5.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex3-5.htm","type":"EX-3.5","id":"NTFILE3T3YVgAieJBKQ1An","market":"us","size":187801},{"description":"EXHIBIT 4.2","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex4-2.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex4-2.htm","type":"EX-4.2","id":"NTFILE79ubzUrZtm7KnGrD","market":"us","size":166971},{"description":"EXHIBIT 10.1","seq":7,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-1.htm","type":"EX-10.1","id":"NTFILE5FhEYZbXkhpkgK42","market":"us","size":374136},{"description":"EXHIBIT 10.2","seq":8,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-2.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-2.htm","type":"EX-10.2","id":"NTFILEFtWyMigqYJLRcVEe","market":"us","size":132716},{"description":"EXHIBIT 10.3","seq":9,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-3.htm","type":"EX-10.3","id":"NTFILEBDv7zFAHi1kuwNvt","market":"us","size":20196},{"description":"EXHIBIT 10.4","seq":10,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-4.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-4.htm","type":"EX-10.4","id":"NTFILEE4t12gtRbBwfTPXi","market":"us","size":197586},{"description":"EXHIBIT 10.5","seq":11,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-5.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-5.htm","type":"EX-10.5","id":"NTFILEfuoKLwTe6xoGZSqp","market":"us","size":71138},{"description":"EXHIBIT 10.6","seq":12,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-6.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-6.htm","type":"EX-10.6","id":"NTFILE6djcAwaLNzwKSa1Y","market":"us","size":276463},{"description":"EXHIBIT 10.7","seq":13,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-7.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-7.htm","type":"EX-10.7","id":"NTFILEDdkLWwWd2UCzKSEP","market":"us","size":76850},{"description":"EXHIBIT 10.8","seq":14,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-8.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-8.htm","type":"EX-10.8","id":"NTFILE27kieTk6q9ztA2CS","market":"us","size":45665},{"description":"EXHIBIT 10.9","seq":15,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-9.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-9.htm","type":"EX-10.9","id":"NTFILEFow9KGXC4RyegFu9","market":"us","size":133391},{"description":"EXHIBIT 10.10","seq":16,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-10.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-10.htm","type":"EX-10.10","id":"NTFILEGbPZijZDA24wfCjD","market":"us","size":50448},{"description":"EXHIBIT 10.11","seq":17,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-11.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-11.htm","type":"EX-10.11","id":"NTFILE91F1ray3viQdS12F","market":"us","size":96428},{"description":"EXHIBIT 10.12","seq":18,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-12.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-12.htm","type":"EX-10.12","id":"NTFILE3fcDQiGk9fMwRGG4","market":"us","size":107779},{"description":"EXHIBIT 21.1","seq":19,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex21-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex21-1.htm","type":"EX-21.1","id":"NTFILE8tatnSgeqj4YJhhL","market":"us","size":2017},{"description":"EXHIBIT 23.1","seq":20,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex23-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex23-1.htm","type":"EX-23.1","id":"NTFILE64LvqHh8kRkHHtW3","market":"us","size":2447},{"description":"EXHIBIT 99.1","seq":21,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex99-1.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex99-1.htm","type":"EX-99.1","id":"NTFILECAUB2jVMAXrkX7Vd","market":"us","size":30058},{"description":"EXHIBIT 99.2","seq":22,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex99-2.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex99-2.htm","type":"EX-99.2","id":"NTFILE2tWjgMmHv1Kw5ViW","market":"us","size":2901},{"description":"EXHIBIT 99.3","seq":23,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex99-3.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex99-3.htm","type":"EX-99.3","id":"NTFILEBSVh5XSs2SBnZNJe","market":"us","size":2912},{"description":"EXHIBIT 99.4","seq":24,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex99-4.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex99-4.htm","type":"EX-99.4","id":"NTFILE7jNeQZbzp81UimQA","market":"us","size":2912},{"description":"EXHIBIT 107","seq":25,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex-filingfees.htm","primary":false,"translateUrl":"","linkName":"tm247121d13_ex-filingfees.htm","type":"EX-FILING FEES","id":"NTFILE2H6GAN6tuf3VByqB","market":"us","size":12423},{"description":"GRAPHIC","seq":26,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_1801part-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part-4c.jpg","type":"GRAPHIC","id":"NTFILEA5C4HaWXstHsMB6C","market":"us","size":89107},{"description":"GRAPHIC","seq":27,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_1801part2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part2-4c.jpg","type":"GRAPHIC","id":"NTFILE5vWhdFrGXDi3JJNo","market":"us","size":68096},{"description":"GRAPHIC","seq":28,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_1801part3b-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b-4c.jpg","type":"GRAPHIC","id":"NTFILE6tBQFbFKKNF2B1f9","market":"us","size":50984},{"description":"GRAPHIC","seq":29,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_1801part3b2-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_1801part3b2-4c.jpg","type":"GRAPHIC","id":"NTFILE39N4FC3xapgxoPeD","market":"us","size":58473},{"description":"GRAPHIC","seq":30,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_8moverl-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_8moverl-4c.jpg","type":"GRAPHIC","id":"NTFILE3Zk9wRAbkxLVZyzk","market":"us","size":85624},{"description":"GRAPHIC","seq":31,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/bc_overallsurvi-4c.jpg","primary":false,"translateUrl":"","linkName":"bc_overallsurvi-4c.jpg","type":"GRAPHIC","id":"NTFILEZ5Do4NYoQmj9ep2A","market":"us","size":82204},{"description":"GRAPHIC","seq":32,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/fc_clinistud-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_clinistud-4c.jpg","type":"GRAPHIC","id":"NTFILE7yzyDLcYcES3kcZg","market":"us","size":89173},{"description":"GRAPHIC","seq":33,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/fc_multimoa-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_multimoa-4c.jpg","type":"GRAPHIC","id":"NTFILE2GzW1JyKzys9XPAM","market":"us","size":94401},{"description":"GRAPHIC","seq":34,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/fc_tcellnk-4c.jpg","primary":false,"translateUrl":"","linkName":"fc_tcellnk-4c.jpg","type":"GRAPHIC","id":"NTFILEAJEcfkRXQPwh8Pz4","market":"us","size":106432},{"description":"GRAPHIC","seq":35,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/lc_elraglarit-4clr.jpg","primary":false,"translateUrl":"","linkName":"lc_elraglarit-4clr.jpg","type":"GRAPHIC","id":"NTFILEE4ccpcT7rAoA8nUs","market":"us","size":41185},{"description":"GRAPHIC","seq":36,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/lc_elrainje-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_elrainje-4c.jpg","type":"GRAPHIC","id":"NTFILE6RE5nfoPN5mNsoD8","market":"us","size":54636},{"description":"GRAPHIC","seq":37,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/lc_gnp-4c.jpg","primary":false,"translateUrl":"","linkName":"lc_gnp-4c.jpg","type":"GRAPHIC","id":"NTFILECukw58Azqf5S7XVM","market":"us","size":78483},{"description":"GRAPHIC","seq":38,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/lg_actuatetherape-4clr.jpg","primary":false,"translateUrl":"","linkName":"lg_actuatetherape-4clr.jpg","type":"GRAPHIC","id":"NTFILE2MDJqCHNaQND5ARS","market":"us","size":9987},{"description":"GRAPHIC","seq":39,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/ph_mri12week-bw.jpg","primary":false,"translateUrl":"","linkName":"ph_mri12week-bw.jpg","type":"GRAPHIC","id":"NTFILE2og6D9CM7as3buDh","market":"us","size":155512},{"description":"GRAPHIC","seq":40,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tb_adverseevent-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_adverseevent-4c.jpg","type":"GRAPHIC","id":"NTFILEDnn8q4gi2K6KANFw","market":"us","size":113661},{"description":"GRAPHIC","seq":41,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tb_elraglusib-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_elraglusib-4c.jpg","type":"GRAPHIC","id":"NTFILE3ZwroaAMdULqbiUU","market":"us","size":112050},{"description":"GRAPHIC","seq":42,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tb_patients-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_patients-4c.jpg","type":"GRAPHIC","id":"NTFILE3TLt21AHFvFYtpVQ","market":"us","size":114028},{"description":"GRAPHIC","seq":43,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tb_route-4c.jpg","primary":false,"translateUrl":"","linkName":"tb_route-4c.jpg","type":"GRAPHIC","id":"NTFILECLzsaceY2SLAd5dj","market":"us","size":21300},{"description":"GRAPHIC","seq":44,"linkUrl":"https://www.sec.gov/Archives/edgar/data/1652935/000110465924065172/tm247121d13_ex10-8img001.jpg","primary":false,"translateUrl":"","linkName":"tm247121d13_ex10-8img001.jpg","type":"GRAPHIC","id":"NTFILEDWRBe62eBbix9YJT","market":"us","size":21321}],"type_name":"Recruitment Registration","type_name_en":"Recruitment Registration","titleTypeEn":"Public Prospectus","us_type":"招股注册","us_type_zh":"招股注册","earn_infos":[],"event_type":"important_notice","event_name":"Public Prospectus","pubTime":"2024-05-24 12:00","pubTimestamp":1716523200,"title_zh":"Form S-1 - General form for registration of securities under the Securities Act of 1933","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":3,"pageCount":3,"totalSize":58,"code":"91000000","status":"200"}]}}