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Celyad Oncology announces the publication of the preclinical and clinical data of CYAD-211 providing proof-of-concept of its miRNA-based shRNA platform

Business Wire

·

18 Feb

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The findings were published in the International Journal of Molecular Science .CYAD-211 is the Company’s first allogeneic chimeric antigen receptor  T-cell candidate, engineered to co-express a B-cell maturation antigen -specific CAR and a microRNA-based single shRNA which interferes with the expression of the CD3ζ component of the T-cell receptor  complex, evaluated clinically.Overall, these data provides the proof-of-concept of the safe administration of CAR T-cells engineered using a miRNA-based shRNA technology. CYAD-211 is the first allogeneic CAR T-cell candidate using a non-gene edited approach to achieve allogenicity. 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