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Denali Therapeutics Inc.

16.44

+0.38002.37%

Post-market: 16.440.00000.00%19:43 EDT

Volume:1.12M

Turnover:18.58M

Market Cap:2.39B

PE:-6.40

High:16.97

Open:16.56

Low:16.21

Close:16.06

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Overview Company News Filings

Denali Therapeutics Shares Down 8.3% Premarket After Co's ALS Drug Fails in Mid-to-Late Stage Trial

THOMSON REUTERS

U.S. Stocks to Watch: Nvidia, Micron, Uber, FuboTV, Aurora Innovation, Plug Power, Inari Medical, and More

BTIG Keeps Their Buy Rating on Denali Therapeutics (DNLI)

Denali Therapeutics Initiated at Outperform by Baird

U.S. RESEARCH ROUNDUP-CNX Resources, Inari Medical, Royal Gold

Analysts Offer Insights on Healthcare Companies: Exact Sciences (EXAS), Denali Therapeutics (DNLI) and Inspire Medical Systems (INSP)

Denali Therapeutics Inc : JP Morgan Cuts Target Price to $24 From $28

THOMSON REUTERS

Stifel likes Denali Therapeutics on weakness

Denali Therapeutics Shares Down 6.2% After the Bell; Denali Therapeutics ALS Drug Fails in Mid-Stage Trial

THOMSON REUTERS

Denali Therapeutics Trial of Potential ALS Treatment Misses Primary, Secondary Endpoints; Shares Fall After Hours

MT Newswires Live

Denali Therapeutics Says ALS Trial Didn't Meet Endpoints

UPDATE 1-Denali Therapeutics' ALS drug fails in mid-to-late stage trial

Denali Therapeutics announces HEALEY ALS trial regimen misses endpoints

Denali Therapeutics ALS drug fails in mid-stage trial

Denali Therapeutics Inc - Study Did Not Meet Primary Endpoint of Slowing Disease Progression

THOMSON REUTERS

Denali Therapeutics Inc - Key Secondary Endpoints Not Statistically Different at Week 24

THOMSON REUTERS

Denali Therapeutics Inc - Dnl343 Found to Be Safe and Well Tolerated

THOMSON REUTERS

Denali Therapeutics Announces Topline Results for Regimen G Evaluating Eif2b Agonist Dnl343 in the Phase 2/3 Healey ALS Platform Trial

THOMSON REUTERS

Denali Therapeutics Announces Topline Results for Regimen G Evaluating eIF2B Agonist DNL343 in the Phase 2/3 HEALEY ALS Platform Trial

Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic

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Gold","url":"https://stock-news.laohu8.com/highlight/detail?id=2501224384","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501224384?lang=en_us&edition=fundamental","pubTime":"2025-01-07 16:32","pubTimestamp":1736238769,"startTime":"0","endTime":"0","summary":"U.S. RESEARCH ROUNDUP-CNX Resources, Inari Medical, Royal GoldJan 7 (Reuters) - Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies, including CNX ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250107:nL4N3O30MD:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["STZ","EE","HAS","CFG","FHI","DFS","ATLC","FITB","NARI","RF","SCHW","LU0098860793.USD","ARQT","FIZN","TROW","LU1894683264.USD","KEY","COF","LU2125154935.USD","USB","STT","BLK","FDX","DNLI","NTRS","BK","BAC","CMA","MTB","BEN","SYF","ALLY","PNC","AMG","HBAN","LU2430703095.HKD","ULTA","WTFC","RGLD","LU0106261372.USD","OPRT","BR","CRMT","KDP","AXP","LU0868494617.USD","CNX","TIL","FCNCA"],"gpt_icon":1},{"id":"2501181247","title":"Analysts Offer Insights on Healthcare Companies: Exact Sciences (EXAS), Denali 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weakness","url":"https://stock-news.laohu8.com/highlight/detail?id=2501292034","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501292034?lang=en_us&edition=fundamental","pubTime":"2025-01-07 08:05","pubTimestamp":1736208333,"startTime":"0","endTime":"0","summary":"Stifel reiterated a Buy rating on Denali Therapeutics (DNLI), saying he continues to like the shares here even as the company announced that its re...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/stifel-likes-denali-therapeutics-on-weakness?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/stifel-likes-denali-therapeutics-on-weakness?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","SF","LENZ","BK4535","BK4127","BK4548","DNLI"],"gpt_icon":0},{"id":"2501053295","title":"Denali Therapeutics Shares Down 6.2% After the Bell; Denali Therapeutics ALS Drug Fails in Mid-Stage 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After Hours","url":"https://stock-news.laohu8.com/highlight/detail?id=2501951932","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501951932?lang=en_us&edition=fundamental","pubTime":"2025-01-07 06:30","pubTimestamp":1736202628,"startTime":"0","endTime":"0","summary":"Denali Therapeutics  said Monday the phase 2/3 Healey-ALS platform trial of eIF2B activator DNL343 as a treatment for amyotrophic lateral sclerosis missed primary and secondary endpoints.\"The study did not meet the primary endpoint of efficacy in slowing disease progression as compared with placebo,\" the company said in a statement. \"Key secondary endpoints, measuring muscle strength and respiratory function, were also not statistically different between the active and placebo groups at week 24.\"\"DNL343 was found to be safe and well tolerated,\" the company said.The company said further evaluation will be conducted later this year, including neurofilament light and other fluid biomarkers, data from prespecified subgroups, as well as extended findings from the active treatment extension period.Shares of the company fell 5.7% in after-hours activity.Price: 18.70, Change: -1.12, Percent Change: -5.65","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4535","BK4548","DNLI","BK4139","LENZ"],"gpt_icon":0},{"id":"2501293634","title":"Denali Therapeutics Says ALS Trial Didn't Meet Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2501293634","media":"Dow 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Secondary endpoints measuring muscle strength and respiratory function weren't statistically different between active and placebo groups.The treatment was found to be safe and well tolerated, and further analyses are anticipated later this year.\"Though the initial top-line clinical results of this trial were not what we hoped, the data collected is valuable in helping to understand the next stage of ALS research,\" said Merit Cudkowicz, the principal investigator of the trial.Shares fell 7.7% to $18.30 in after-market trading.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4548","BK4139","LENZ","BK4535","DNLI"],"gpt_icon":0},{"id":"2501298047","title":"UPDATE 1-Denali Therapeutics' ALS drug fails in mid-to-late stage trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501298047","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501298047?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:59","pubTimestamp":1736200774,"startTime":"0","endTime":"0","summary":"(Adds details on study and next steps in paragraphs 2-4)      Jan 6 (Reuters) - Denali Therapeutics    said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial in","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.rkd.refinitiv.com/api/News/News.svc/REST/News_1/RetrieveStoryML_1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4548","BK4535","DNLI","LENZ"],"gpt_icon":0},{"id":"2501298420","title":"Denali Therapeutics announces HEALEY ALS trial regimen misses endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2501298420","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501298420?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:40","pubTimestamp":1736199657,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) announced topline results from an analysis of Regimen G of the Phase 2/3 HEALEY ALS Platform Trial evaluating eIF2B agon...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-healey-als-trial-regimen-misses-endpoints?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-healey-als-trial-regimen-misses-endpoints?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4548","DNLI","LENZ","BK4139","BK4535"],"gpt_icon":0},{"id":"2501260048","title":"Denali Therapeutics ALS drug fails in mid-stage trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501260048","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501260048?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:38","pubTimestamp":1736199483,"startTime":"0","endTime":"0","summary":"Denali Therapeutics ALS drug fails in mid-stage trialJan 6  - Denali Therapeutics DNLI.O said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial in patients with amyotrophic lateral sclerosis , a fatal neurodegenerative disease.  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