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Denali Therapeutics Inc.

19.96

-0.1500-0.75%

Post-market: 19.70-0.2600-1.30%19:26 EST

Volume:2.02M

Turnover:40.62M

Market Cap:2.93B

PE:-6.86

High:20.61

Open:20.37

Low:19.94

Close:20.11

52wk High:26.18

52wk Low:10.57

Shares:146.66M

Float Shares:132.11M

Volume Ratio:1.29

T/O Rate:1.53%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-2.9114

EPS(LYR):-2.5705

ROE:-44.44%

ROA:-27.29%

PB:3.16

PE(LYR):-7.77

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Overview Company News Filings

Concept

Temasek Holdings+0.47%

Baillie Gifford Holdings+0.28%

Capital Flow

Inflow:

Outflow:

News

Denali Flags Minimal Delay After FDA Halts Rare Disease Trial Start

Benzinga_recent_news

Denali Therapeutics, Royalty Pharma Enter $275 Million Royalty Funding Agreement for Hunter Syndrome Treatment

Denali Therapeutics Inc - Royalty Pharma to Receive 9.25% Royalty on Worldwide Sales of Tividenofusp Alfa From Denali

THOMSON REUTERS

Press Release: Denali Therapeutics and Royalty Pharma Announce $275 Million Royalty Funding Agreement

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Flags Minimal Delay After FDA Halts Rare Disease Trial Start","url":"https://stock-news.laohu8.com/highlight/detail?id=2589981924","media":"Benzinga_recent_news","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589981924?lang=en_us&edition=fundamental","pubTime":"2025-12-06 00:49","pubTimestamp":1764953340,"startTime":"0","endTime":"0","summary":"FDA placed hold on Denali's drug for Pompe disease, requesting changes to protocol. No additional studies requested. Minimal delays expected.","market":"sh","thumbnail":"https://cdn.benzinga.com/files/images/story/2025/12/05/FDA.jpeg?optimize=medium&dpr=2&auto=webp&width=240","type":0,"news_type":0,"thumbnails":["https://cdn.benzinga.com/files/images/story/2025/12/05/FDA.jpeg?optimize=medium&dpr=2&auto=webp&width=240"],"rights":{"source":"benzinga_recent_news","url":"https://www.benzinga.com/news/fda/25/12/49235359/denali-flags-minimal-delay-after-fda-halts-rare-disease-trial-start","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/fda/25/12/49235359/denali-flags-minimal-delay-after-fda-halts-rare-disease-trial-start","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"benzinga_recent_news","symbols":["IND","BK4548","DNLI","BK4139","RPRX","BK4535","BK4007"],"gpt_icon":0},{"id":"2588488474","title":"Denali Therapeutics, Royalty Pharma Enter $275 Million Royalty Funding Agreement for Hunter Syndrome Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2588488474","media":"Dow Jones","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588488474?lang=en_us&edition=fundamental","pubTime":"2025-12-04 21:06","pubTimestamp":1764853560,"startTime":"0","endTime":"0","summary":"Denali Therapeutics and Royalty Pharma entered a $275 million royalty funding agreement based on future sales of tividenofusp alfa.The companies said Thursday that the agreement is subject to various closing conditions. These include Denali receiving accelerated approval from the U.S. Food and Drug Administration for the treatment. A biologics license application for the accelerated approval of the treatment is currently under review by the FDA.Under the deal, Royalty Pharma would make an initial $200 million payment at the closing, as well as an additional $75 million payment if the treatment is approved by the European Medicines Agency by Dec. 31, 2029.In exchange, Royalty Pharma will receive a 9.25% royalty on worldwide net sales of tividenofusp alfa from Denali.The royalty payments would cease upon reaching a 3x multiple, or 2.5x multiple if achieved by the first quarter of 2039, the companies said.Royalty Pharma Chief Executive Pablo Legorreta said the company is \"thrilled to esta","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4539","BK4535","BK4548","BK4139","DNLI","RPRX","LENZ","BK4007"],"gpt_icon":0},{"id":"2588288964","title":"Denali Therapeutics Inc - Royalty Pharma to Receive 9.25% Royalty on Worldwide Sales of Tividenofusp Alfa From Denali","url":"https://stock-news.laohu8.com/highlight/detail?id=2588288964","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588288964?lang=en_us&edition=fundamental","pubTime":"2025-12-04 20:00","pubTimestamp":1764849601,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251204:nTUA30ZTCF:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4535","BK4548","RPRX","BK4007","DNLI","BK4139"],"gpt_icon":0},{"id":"2588889672","title":"Press Release: Denali Therapeutics and Royalty Pharma Announce $275 Million Royalty Funding Agreement","url":"https://stock-news.laohu8.com/highlight/detail?id=2588889672","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588889672?lang=en_us&edition=fundamental","pubTime":"2025-12-04 20:00","pubTimestamp":1764849600,"startTime":"0","endTime":"0","summary":"SOUTH SAN FRANCISCO, Calif. and NEW YORK, Dec. 04, 2025  -- Denali Therapeutics Inc.  and Royalty Pharma plc  today announced a $275 million synthetic royalty funding agreement based on future net sales of tividenofusp alfa.\"We are delighted to partner with Denali and acquire a royalty on tividenofusp alfa, an innovative therapy that addresses a significant unmet need in the cognitive and physical manifestations of Hunter syndrome,\" said Pablo Legorreta, Chief Executive Officer and Chairman of the Board of Royalty Pharma. \"Denali's technology platform delivers therapeutics across the blood-brain barrier and is a promising new approach to brain diseases. We are thrilled to establish a relationship with Denali and believe tividenofusp alfa is a potential practice-changing therapy that could transform the lives of patients with Hunter syndrome.\"","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4588","BK4099","BK4604","BK4555","BK4548","DNLI","BK4139","EMA","LENZ","03160","BK4081","BK4585","TM","BK4539","BK4535","BK4007"],"gpt_icon":0}],"pageSize":4,"totalPage":9,"pageCount":1,"totalSize":34,"code":"91000000","status":"200"}],"@#url:\"https://hq.skytigris.cn/market/plate/belongs/DNLI\",params:#limit:6,delay:false,,,undefined,":[{"market":"US","name":"Temasek Holdings","bkCode":"BK4535","id":"package_us_concept_dmxcc","changeRate":0.004705},{"market":"US","name":"Baillie Gifford Holdings","bkCode":"BK4548","id":"package_us_concept_bmljfcc","changeRate":0.002791}]}}