US StockDetailed Quotes

Provided by Tiger Trade Technology Pte. Ltd.

Ionis Pharmaceuticals

77.08

-1.2900-1.65%

Post-market: 75.59-1.4900-1.93%17:50 EST

Volume:2.15M

Turnover:166.83M

Market Cap:12.48B

PE:-47.78

High:79.49

Open:78.77

Low:77.07

Close:78.37

52wk High:83.61

52wk Low:23.95

Shares:161.97M

Float Shares:161.00M

Volume Ratio:1.06

T/O Rate:1.33%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.6132

EPS(LYR):-3.0358

ROE:-40.04%

ROA:-5.68%

PB:20.20

PE(LYR):-25.39

Loading ...

Overview Company News Filings

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

Major Issues Report

Form 8-K - Current report

Proposed Sale Of Securities

Form 144 - Report of proposed sale of securities

{"basename":"","ssrTDKData":{"titleTemplate":"%s - Tiger Brokers","title":"Tiger Brokers | Global Stocks, Options & Futures Trading App","description":"Tiger Brokers, one-stop investment in US stocks, SGX stocks, HK stocks, A-shares & other global assets. One of the best stock trading platforms in Singapore.","keywords":"tiger brokers,tiger trade,tiger brokers singapore,broker online,stock trading in singapore,share trading singapore,brokerage firm singapore,trading app,stock broker singapore,stock trading platforms,trading account","social":{"ogDescription":"Tiger Brokers, one-stop investment in US stocks, SGX stocks, HK stocks, A-shares & other global assets. One of the best stock trading platforms in Singapore.","ogImage":"https://c1.itigergrowtha.com/portal5/static/media/og-logo.be62fbe1.png","ogUrl":"https://www.itiger.com/stock/IONS/filings?page=2"},"companyName":"Tiger Brokers"},"pageData":{"isMobile":false,"isTiger":false,"isTTM":true,"region":"SGP","license":"TBSG","edition":"fundamental","symbol":"IONS","isAnalysisPage":false},"__swrFallback__":{"@#url:\"https://hq.skytigris.cn/stock_info/detail/global\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","market":"US","secType":"STK","nameCN":"Ionis Pharmaceuticals","latestPrice":77.08,"timestamp":1766005200000,"preClose":78.37,"halted":0,"volume":2145804,"hourTrading":{"tag":"盘后","latestPrice":75.59,"preClose":77.08,"latestTime":"17:50 EST","volume":379999,"amount":29290246.9202,"timestamp":1766011828753},"delay":0,"floatShares":161000000,"shares":161974393,"eps":-1.613241,"marketStatus":"Post-Mkt","change":-1.29,"latestTime":"12-17 18:51:26 EST","open":78.77,"high":79.49,"low":77.07,"amount":166832986.503096,"amplitude":0.030879,"askPrice":78.61,"askSize":25,"bidPrice":75.58,"bidSize":26,"shortable":3,"etf":0,"ttmEps":-1.613241,"tradingStatus":3,"nextMarketStatus":{"tag":"Closed","tradingStatus":0,"beginTime":1766019600000},"marketStatusCode":4,"adr":0,"adrRate":0,"exchange":"NASDAQ","adjPreClose":78.37,"preHourTrading":{"tag":"盘前","latestPrice":78.95,"preClose":78.37,"latestTime":"09:27 EST","volume":303,"amount":23773.002764999997,"timestamp":1765981670040},"postHourTrading":{"tag":"盘后","latestPrice":75.59,"preClose":77.08,"latestTime":"17:50 EST","volume":379999,"amount":29290246.9202,"timestamp":1766011828753},"volumeRatio":1.060412,"optionData":{"bulkOrders":[{"symbol":"IONS","call":false,"expireDate":1768539600000,"strike":"75.0","timestamp":1766003745352,"price":3.5,"volume":2805,"amount":981750,"type":"+"}]},"impliedVol":0.5275,"impliedVolPercentile":0.784},"@#url:\"https://hq.skytigris.cn/stock_info/fundamental/all\",params:#delay:false,,method:\"POST\",data:#items:@#symbol:\"IONS\",,,,,undefined,":{"symbol":"IONS","floatShares":161000000,"roa":"-5.68%","roe":"-40.04%","lyrEps":-3.035816,"volumeRatio":1.060412,"shares":161974393,"dividePrice":0,"high":79.49,"amplitude":0.030879,"preClose":78.37,"low":77.07,"week52Low":23.95,"pbRate":"20.20","psRate":"12.91","week52High":83.61,"institutionHeld":0.9665,"latestPrice":77.08,"committee":0.019608,"eps":-1.613241,"divideRate":0,"volume":2145804,"delay":0,"ttmEps":-1.613241,"open":78.77,"prevYearClose":34.96,"prevWeekClose":80.82,"prevMonthClose":82.73,"prevQuarterClose":65.42,"fiveDayClose":78.63,"twentyDayClose":74.5,"sixtyDayClose":62.57},"@#url:\"https://hq.skytigris.cn/fundamental/corporate_actions/details/IONS\",params:#limit:5,,,undefined,":[{"market":"US","date":"2025-10-29","symbol":"IONS","fiscalQuarterEnding":"2025/09","expectedEps":-1.23,"name":null,"time":"Pre-Market","type":"earning","dateTimestamp":1761710400000,"reportTimeType":"pre","actualEps":-0.8},{"market":"US","date":"2025-07-30","symbol":"IONS","fiscalQuarterEnding":"2025/06","expectedEps":-0.11,"name":null,"time":"Pre-Market","type":"earning","dateTimestamp":1753848000000,"reportTimeType":"pre","actualEps":0.7},{"market":"US","date":"2025-04-30","symbol":"IONS","fiscalQuarterEnding":"2025/03","expectedEps":-1.16,"name":null,"time":"Pre-Market","type":"earning","dateTimestamp":1745985600000,"reportTimeType":"pre","actualEps":-0.93},{"market":"US","date":"2025-02-19","symbol":"IONS","fiscalQuarterEnding":"2024/12","expectedEps":-1.12,"name":null,"time":"Pre-Market","type":"earning","dateTimestamp":1739941200000,"reportTimeType":"pre","actualEps":-0.66},{"market":"US","date":"2024-11-06","symbol":"IONS","fiscalQuarterEnding":"2024/09","expectedEps":-1.16,"name":null,"time":"Pre-Market","type":"earning","dateTimestamp":1730869200000,"reportTimeType":"pre","actualEps":-0.95}],"@#url:\"https://hq.skytigris.cn/fundamental/dividend/history\",params:#symbol:\"IONS\",market:\"US\",,,undefined,":[],"@#url:\"https://hq.skytigris.cn/fundamental/estimate/recommendation\",params:#symbol:\"IONS\",market:\"US\",delay:false,,,undefined,":{"strongBuy":0.375,"buy":0.375,"hold":0.25,"sell":0,"strongSell":0,"meanLabel":"BUY","meanPercent":0.375,"analysts":24,"updateTime":1763096400000},"@#url:\"https://hq.skytigris.cn/value_analysis/stock/IONS\",params:#withQuantilePoint:true,period:\"5year\",factor:\"peRate\",delay:false,algorithm:1,,,undefined,":{"brief":{"id":"IONS","date":"2025-12-16","current":-48.114324,"percent":0.153534,"low":-1664.931905,"twenty":-36.342835,"median":-16.749269,"eighty":-9.897883,"high":882.260453,"avg":-57.845025,"sd":367.275195,"marketCap":12919077585},"quantilePoints":[{"date":"2020-12-18","current":80.230141,"twenty":-113.636217,"median":21.41827,"eighty":153.862048,"marketCap":7596590924},{"date":"2020-12-24","current":88.130588,"twenty":-113.636217,"median":21.642767,"eighty":153.862048,"marketCap":8344644696},{"date":"2020-12-31","current":83.49369,"twenty":-113.636217,"median":21.830973,"eighty":153.862048,"marketCap":7905600052},{"date":"2021-01-08","current":90.138925,"twenty":-113.636217,"median":22.082828,"eighty":153.862048,"marketCap":8534804160},{"date":"2021-01-15","current":90.493338,"twenty":-113.636217,"median":22.203503,"eighty":153.862048,"marketCap":8568361712},{"date":"2021-01-22","current":91.187396,"twenty":-113.636217,"median":22.502904,"eighty":153.862048,"marketCap":8634078586},{"date":"2021-01-29","current":88.706508,"twenty":-113.636217,"median":22.994546,"eighty":153.862048,"marketCap":8399175719},{"date":"2021-02-05","current":88.883714,"twenty":-113.636217,"median":23.497803,"eighty":153.862048,"marketCap":8415954495},{"date":"2021-02-12","current":84.261584,"twenty":-113.636217,"median":23.777034,"eighty":153.862048,"marketCap":7978308083},{"date":"2021-02-19","current":85.191917,"twenty":-113.636217,"median":23.943454,"eighty":153.862048,"marketCap":8066396658},{"date":"2021-02-26","current":-16.614438,"twenty":-113.636217,"median":24.070194,"eighty":153.862048,"marketCap":7381179856},{"date":"2021-03-05","current":-16.734924,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":7434707496},{"date":"2021-03-12","current":-16.801508,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":7464288560},{"date":"2021-03-19","current":-17.188333,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":7636140458},{"date":"2021-03-26","current":-13.618132,"twenty":-113.636217,"median":24.070194,"eighty":153.862048,"marketCap":6050031962},{"date":"2021-04-01","current":-14.283977,"twenty":-113.636217,"median":24.070194,"eighty":153.862048,"marketCap":6345842605},{"date":"2021-04-09","current":-13.431061,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":5966923257},{"date":"2021-04-16","current":-12.930091,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":5744360964},{"date":"2021-04-23","current":-13.542136,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":6016269938},{"date":"2021-04-30","current":-13.583375,"twenty":-113.715351,"median":24.094838,"eighty":153.903551,"marketCap":6034590741},{"date":"2021-05-07","current":-10.416072,"twenty":-112.558018,"median":24.094838,"eighty":153.903551,"marketCap":5150789043},{"date":"2021-05-14","current":-10.900673,"twenty":-110.935774,"median":24.094838,"eighty":153.903551,"marketCap":5390426190},{"date":"2021-05-21","current":-10.322002,"twenty":-108.007821,"median":24.094838,"eighty":153.903551,"marketCap":5104271243},{"date":"2021-05-28","current":-10.618464,"twenty":-103.625784,"median":24.094838,"eighty":153.903551,"marketCap":5250872793},{"date":"2021-06-04","current":-9.845953,"twenty":-51.294186,"median":24.094838,"eighty":153.903551,"marketCap":4868862987},{"date":"2021-06-11","current":-10.812304,"twenty":-50.272801,"median":24.094838,"eighty":153.903551,"marketCap":5346727652},{"date":"2021-06-18","current":-10.772396,"twenty":-49.437626,"median":24.094838,"eighty":153.903551,"marketCap":5326992828},{"date":"2021-06-25","current":-11.097364,"twenty":-48.412553,"median":24.094838,"eighty":153.903551,"marketCap":5487690680},{"date":"2021-07-02","current":-11.379572,"twenty":-48.099131,"median":24.094838,"eighty":153.903551,"marketCap":5627244077},{"date":"2021-07-09","current":-11.08026,"twenty":-47.813364,"median":24.094838,"eighty":153.903551,"marketCap":5479232898},{"date":"2021-07-16","current":-10.418922,"twenty":-46.987407,"median":24.094838,"eighty":153.903551,"marketCap":5152198673},{"date":"2021-07-23","current":-10.84081,"twenty":-46.428779,"median":24.094838,"eighty":153.903551,"marketCap":5360823954},{"date":"2021-07-30","current":-10.587107,"twenty":-45.619415,"median":24.094838,"eighty":153.903551,"marketCap":5235366859},{"date":"2021-08-06","current":-9.961983,"twenty":-44.489253,"median":24.094838,"eighty":153.903551,"marketCap":5476530682},{"date":"2021-08-13","current":-10.187925,"twenty":-43.823694,"median":23.887124,"eighty":151.247358,"marketCap":5600740656},{"date":"2021-08-20","current":-10.080089,"twenty":-43.823694,"median":23.605478,"eighty":146.702778,"marketCap":5541458623},{"date":"2021-08-27","current":-10.175088,"twenty":-43.823694,"median":23.306229,"eighty":141.027241,"marketCap":5593683271},{"date":"2021-09-03","current":-10.146845,"twenty":-43.823694,"median":22.806307,"eighty":135.009304,"marketCap":5578157024},{"date":"2021-09-10","current":-9.266185,"twenty":-43.823694,"median":22.273726,"eighty":92.336284,"marketCap":5094020420},{"date":"2021-09-17","current":-9.553748,"twenty":-43.823694,"median":22.105712,"eighty":90.484478,"marketCap":5252105842},{"date":"2021-09-24","current":-9.294428,"twenty":-43.823694,"median":21.894477,"eighty":89.822908,"marketCap":5109546667},{"date":"2021-10-01","current":-8.61917,"twenty":-43.823694,"median":21.739571,"eighty":88.160122,"marketCap":4738328221},{"date":"2021-10-08","current":-8.752681,"twenty":-43.823694,"median":21.475528,"eighty":87.371554,"marketCap":4811725024},{"date":"2021-10-15","current":-9.012001,"twenty":-43.823694,"median":21.145012,"eighty":86.264015,"marketCap":4954284199},{"date":"2021-10-22","current":-7.815535,"twenty":-43.823694,"median":21.004285,"eighty":84.663252,"marketCap":4296535927},{"date":"2021-10-29","current":-8.182691,"twenty":-43.823694,"median":20.82218,"eighty":83.19244,"marketCap":4498377135},{"date":"2021-11-05","current":-7.827936,"twenty":-43.823694,"median":20.669316,"eighty":82.070133,"marketCap":4757365405},{"date":"2021-11-12","current":-7.595584,"twenty":-43.823694,"median":20.616507,"eighty":76.079084,"marketCap":4616155390},{"date":"2021-11-19","current":-7.432938,"twenty":-43.823694,"median":20.366546,"eighty":75.49578,"marketCap":4517308379},{"date":"2021-11-26","current":-6.749823,"twenty":-43.823694,"median":20.294106,"eighty":74.547727,"marketCap":4102150935},{"date":"2021-12-03","current":-6.131767,"twenty":-43.823694,"median":20.173015,"eighty":74.030875,"marketCap":3726532295},{"date":"2021-12-10","current":-6.847411,"twenty":-43.823694,"median":20.114106,"eighty":72.607318,"marketCap":4161459142},{"date":"2021-12-17","current":-7.542143,"twenty":-43.823694,"median":20.025743,"eighty":70.436541,"marketCap":4583677086},{"date":"2021-12-23","current":-7.600231,"twenty":-43.823694,"median":19.891562,"eighty":60.214071,"marketCap":4618979590},{"date":"2021-12-31","current":-7.070469,"twenty":-43.823694,"median":19.796653,"eighty":53.012098,"marketCap":4297020756},{"date":"2022-01-07","current":-7.058851,"twenty":-43.611673,"median":19.749198,"eighty":51.923862,"marketCap":4289960255},{"date":"2022-01-14","current":-7.686201,"twenty":-43.611673,"median":19.64938,"eighty":51.147099,"marketCap":4671227296},{"date":"2022-01-21","current":-6.942675,"twenty":-43.611673,"median":19.61175,"eighty":50.934296,"marketCap":4219355248},{"date":"2022-01-28","current":-7.360909,"twenty":-43.611673,"median":19.468798,"eighty":50.847883,"marketCap":4473533275},{"date":"2022-02-04","current":-7.319085,"twenty":-43.611673,"median":19.28882,"eighty":50.5876,"marketCap":4448115472},{"date":"2022-02-11","current":-7.639731,"twenty":-43.611673,"median":19.164904,"eighty":50.143461,"marketCap":4642985293},{"date":"2022-02-18","current":-7.497996,"twenty":-43.611673,"median":18.965356,"eighty":49.908881,"marketCap":4556847184},{"date":"2022-02-25","current":-157.459445,"twenty":-44.533501,"median":18.77393,"eighty":49.713145,"marketCap":4502867744},{"date":"2022-03-04","current":-160.035874,"twenty":-45.829592,"median":18.155386,"eighty":49.32903,"marketCap":4576545882},{"date":"2022-03-11","current":-159.49086,"twenty":-46.633425,"median":-6.144547,"eighty":48.69515,"marketCap":4560960122},{"date":"2022-03-18","current":-174.652153,"twenty":-47.12015,"median":-6.881102,"eighty":48.427938,"marketCap":4994527626},{"date":"2022-03-25","current":-181.687786,"twenty":-47.927671,"median":-7.000763,"eighty":48.265452,"marketCap":5195725619},{"date":"2022-04-01","current":-192.736702,"twenty":-48.230031,"median":-7.040263,"eighty":47.833218,"marketCap":5511691480},{"date":"2022-04-08","current":-198.781401,"twenty":-48.689101,"median":-7.082087,"eighty":47.228668,"marketCap":5684551727},{"date":"2022-04-14","current":-202.992871,"twenty":-49.716018,"median":-7.119262,"eighty":46.918857,"marketCap":5804987145},{"date":"2022-04-22","current":-206.852389,"twenty":-50.435043,"median":-7.237762,"eighty":46.570634,"marketCap":5915357781},{"date":"2022-04-29","current":-182.216483,"twenty":-51.591015,"median":-7.300497,"eighty":46.245658,"marketCap":5210844764},{"date":"2022-05-06","current":-1322.183946,"twenty":-128.214398,"median":-7.341159,"eighty":45.925265,"marketCap":5147262100},{"date":"2022-05-13","current":-1314.170709,"twenty":-130.326929,"median":-7.37485,"eighty":45.90793,"marketCap":5116066572},{"date":"2022-05-20","current":-1438.375868,"twenty":-130.86667,"median":-7.37485,"eighty":45.90793,"marketCap":5599597254},{"date":"2022-05-27","current":-1370.6276,"twenty":-132.625178,"median":-7.37485,"eighty":45.90793,"marketCap":5335853246},{"date":"2022-06-03","current":-1316.720376,"twenty":-134.128325,"median":-7.37485,"eighty":45.90793,"marketCap":5125992422},{"date":"2022-06-10","current":-1266.091293,"twenty":-137.45382,"median":-7.37485,"eighty":45.90793,"marketCap":4928893405},{"date":"2022-06-17","current":-1284.303193,"twenty":-139.005646,"median":-7.37485,"eighty":45.90793,"marketCap":4999792332},{"date":"2022-06-24","current":-1429.634156,"twenty":-139.862338,"median":-7.360909,"eighty":45.909339,"marketCap":5565565769},{"date":"2022-07-01","current":-1386.289834,"twenty":-141.353878,"median":-7.360909,"eighty":45.909339,"marketCap":5396826323},{"date":"2022-07-08","current":-1353.144176,"twenty":-142.456573,"median":-7.360909,"eighty":45.909339,"marketCap":5267790276},{"date":"2022-07-15","current":-1431.819584,"twenty":-143.808127,"median":-7.360909,"eighty":45.909339,"marketCap":5574073640},{"date":"2022-07-22","current":-1387.746786,"twenty":-144.656772,"median":-7.360909,"eighty":45.909339,"marketCap":5402498237},{"date":"2022-07-29","current":-1368.077934,"twenty":-146.022974,"median":-7.360909,"eighty":45.909339,"marketCap":5325927396},{"date":"2022-08-05","current":-1664.567667,"twenty":-147.819198,"median":-7.360909,"eighty":45.909339,"marketCap":6480161927},{"date":"2022-08-12","current":-222.342663,"twenty":-148.698169,"median":-7.360909,"eighty":45.909339,"marketCap":6259613005},{"date":"2022-08-19","current":-221.838485,"twenty":-149.407406,"median":-7.360909,"eighty":45.909339,"marketCap":6245418872},{"date":"2022-08-26","current":-213.519542,"twenty":-149.883165,"median":-7.360909,"eighty":45.909339,"marketCap":6011215664},{"date":"2022-09-02","current":-218.006729,"twenty":-150.165357,"median":-7.360909,"eighty":45.909339,"marketCap":6137543455},{"date":"2022-09-09","current":-236.157151,"twenty":-151.092649,"median":-7.360909,"eighty":45.909339,"marketCap":6648532271},{"date":"2022-09-16","current":-233.585841,"twenty":-153.529951,"median":-7.360909,"eighty":45.909339,"marketCap":6576142189},{"date":"2022-09-23","current":-217.956312,"twenty":-156.46647,"median":-7.360909,"eighty":45.909339,"marketCap":6136124041},{"date":"2022-09-30","current":-222.998095,"twenty":-157.969129,"median":-7.360909,"eighty":45.909339,"marketCap":6278065379},{"date":"2022-10-07","current":-231.569128,"twenty":-159.577078,"median":-7.360909,"eighty":45.909339,"marketCap":6519365654},{"date":"2022-10-14","current":-233.737095,"twenty":-160.082841,"median":-7.360909,"eighty":45.909339,"marketCap":6580400429},{"date":"2022-10-21","current":-226.62818,"twenty":-160.43291,"median":-7.360909,"eighty":45.909339,"marketCap":6380263143},{"date":"2022-10-28","current":-224.913973,"twenty":-161.94987,"median":-7.360909,"eighty":45.909339,"marketCap":6332003088},{"date":"2022-11-04","current":-209.486115,"twenty":-162.370971,"median":-7.360909,"eighty":45.909339,"marketCap":5897662593},{"date":"2022-11-11","current":839.185498,"twenty":-162.756411,"median":-7.319085,"eighty":46.031035,"marketCap":6143677032},{"date":"2022-11-18","current":836.080997,"twenty":-162.756411,"median":-7.284232,"eighty":46.34415,"marketCap":6120948978},{"date":"2022-11-25","current":806.394204,"twenty":-162.756411,"median":-7.219174,"eighty":46.64061,"marketCap":5903611964},{"date":"2022-12-02","current":782.334319,"twenty":-162.756411,"median":-7.102998,"eighty":47.141347,"marketCap":5727469547},{"date":"2022-12-09","current":727.617484,"twenty":-162.756411,"median":-7.058851,"eighty":47.387939,"marketCap":5326887600},{"date":"2022-12-16","current":750.125118,"twenty":-162.756411,"median":-7.014704,"eighty":48.047842,"marketCap":5491665989},{"date":"2022-12-23","current":740.423552,"twenty":-162.756411,"median":-6.972881,"eighty":48.293594,"marketCap":5420640821},{"date":"2022-12-30","current":732.85633,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5365241190},{"date":"2023-01-06","current":786.214945,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5755879614},{"date":"2023-01-13","current":773.214846,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5660705889},{"date":"2023-01-20","current":790.871697,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5789971695},{"date":"2023-01-27","current":776.513379,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5684854446},{"date":"2023-02-03","current":793.976198,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5812699749},{"date":"2023-02-10","current":756.722183,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5539963104},{"date":"2023-02-17","current":748.96093,"twenty":-162.756411,"median":-6.749823,"eighty":48.503303,"marketCap":5483142969},{"date":"2023-02-24","current":-18.915876,"twenty":-162.756411,"median":-6.942675,"eighty":48.318169,"marketCap":5102028010},{"date":"2023-03-03","current":-19.398181,"twenty":-162.756411,"median":-7.010057,"eighty":48.167441,"marketCap":5232116143},{"date":"2023-03-10","current":-17.998968,"twenty":-162.756411,"median":-7.047233,"eighty":47.522459,"marketCap":4854717602},{"date":"2023-03-17","current":-18.645574,"twenty":-162.756411,"median":-7.096027,"eighty":47.151665,"marketCap":5029121473},{"date":"2023-03-24","current":-17.993668,"twenty":-162.756411,"median":-7.188968,"eighty":46.719576,"marketCap":4853288062},{"date":"2023-03-31","current":-18.942377,"twenty":-162.739653,"median":-7.283071,"eighty":46.447558,"marketCap":5109175709},{"date":"2023-04-06","current":-19.392881,"twenty":-162.739653,"median":-7.309791,"eighty":46.139197,"marketCap":5230686603},{"date":"2023-04-14","current":-19.906986,"twenty":-162.756411,"median":-7.388791,"eighty":45.881909,"marketCap":5369351977},{"date":"2023-04-21","current":-19.158378,"twenty":-162.756411,"median":-7.484055,"eighty":45.586713,"marketCap":5167435947},{"date":"2023-04-28","current":-18.691747,"twenty":-162.756411,"median":-7.542143,"eighty":45.238708,"marketCap":5041575343},{"date":"2023-05-05","current":-15.654507,"twenty":-162.722895,"median":-7.581643,"eighty":45.096531,"marketCap":5148454369},{"date":"2023-05-12","current":-15.484823,"twenty":-162.005118,"median":-7.581643,"eighty":45.096531,"marketCap":5092648444},{"date":"2023-05-19","current":-15.937315,"twenty":-160.611822,"median":-7.581643,"eighty":45.096531,"marketCap":5241464245},{"date":"2023-05-26","current":-17.042442,"twenty":-160.205418,"median":-7.581643,"eighty":45.096531,"marketCap":5604918222},{"date":"2023-06-02","current":-18.682728,"twenty":-159.773437,"median":-7.581643,"eighty":45.096531,"marketCap":6144375503},{"date":"2023-06-09","current":-18.121463,"twenty":-159.192484,"median":-7.581643,"eighty":45.096531,"marketCap":5959786673},{"date":"2023-06-16","current":-18.138866,"twenty":-156.985977,"median":-7.581643,"eighty":45.096531,"marketCap":5965510357},{"date":"2023-06-23","current":-17.925673,"twenty":-155.435521,"median":-7.578157,"eighty":45.109315,"marketCap":5895395220},{"date":"2023-06-30","current":-17.886515,"twenty":-151.740635,"median":-7.574672,"eighty":45.122099,"marketCap":5882516929},{"date":"2023-07-07","current":-18.169323,"twenty":-150.657265,"median":-7.574672,"eighty":45.122099,"marketCap":5975526805},{"date":"2023-07-14","current":-18.560903,"twenty":-150.083568,"median":-7.574672,"eighty":45.122099,"marketCap":6104309711},{"date":"2023-07-21","current":-17.821251,"twenty":-149.641501,"median":-7.574672,"eighty":45.122099,"marketCap":5861053112},{"date":"2023-07-28","current":-16.750932,"twenty":-149.090615,"median":-7.574672,"eighty":45.122099,"marketCap":5509046504},{"date":"2023-08-04","current":-17.151214,"twenty":-148.303568,"median":-7.574672,"eighty":45.122099,"marketCap":5640691252},{"date":"2023-08-11","current":-18.467972,"twenty":-148.00823,"median":-7.574672,"eighty":45.122099,"marketCap":5707249602},{"date":"2023-08-18","current":-18.147959,"twenty":-147.735407,"median":-7.574672,"eighty":45.122099,"marketCap":5608354519},{"date":"2023-08-25","current":-18.463334,"twenty":-145.579013,"median":-7.574672,"eighty":45.122099,"marketCap":5705816340},{"date":"2023-09-01","current":-18.676675,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5771746396},{"date":"2023-09-08","current":-18.727692,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":5787512279},{"date":"2023-09-15","current":-20.239635,"twenty":-145.219114,"median":-7.574672,"eighty":45.122099,"marketCap":6254755717},{"date":"2023-09-22","current":-19.701643,"twenty":-144.797122,"median":-7.574672,"eighty":45.122099,"marketCap":6088497315},{"date":"2023-09-29","current":-21.454756,"twenty":-143.400598,"median":-7.574672,"eighty":45.122099,"marketCap":6630270382},{"date":"2023-10-06","current":-21.728389,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6714832844},{"date":"2023-10-13","current":-21.38055,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6607338188},{"date":"2023-10-20","current":-21.593891,"twenty":-143.032342,"median":-7.574672,"eighty":45.122099,"marketCap":6673268244},{"date":"2023-10-27","current":-21.16257,"twenty":-143.300049,"median":-7.55957,"eighty":45.146419,"marketCap":6539974871},{"date":"2023-11-03","current":-15.297336,"twenty":-140.032184,"median":-7.55957,"eighty":45.146419,"marketCap":6267655075},{"date":"2023-11-10","current":-16.577399,"twenty":-22.395314,"median":-7.55957,"eighty":45.146419,"marketCap":6787665949},{"date":"2023-11-17","current":-17.008391,"twenty":-21.672735,"median":-7.55957,"eighty":45.146419,"marketCap":6964136656},{"date":"2023-11-24","current":-17.460406,"twenty":-21.484438,"median":-7.55957,"eighty":45.146419,"marketCap":7149215689},{"date":"2023-12-01","current":-17.334262,"twenty":-21.2275,"median":-7.55957,"eighty":45.146419,"marketCap":7097565726},{"date":"2023-12-08","current":-17.334262,"twenty":-20.411236,"median":-7.572349,"eighty":45.140651,"marketCap":7097565726},{"date":"2023-12-15","current":-17.456902,"twenty":-20.127399,"median":-7.572349,"eighty":45.140651,"marketCap":7147780968},{"date":"2023-12-22","current":-17.208119,"twenty":-19.907658,"median":-7.572349,"eighty":45.140651,"marketCap":7045915764},{"date":"2023-12-29","current":-17.695174,"twenty":-19.76602,"median":-7.55957,"eighty":45.146419,"marketCap":7245342009},{"date":"2024-01-05","current":-18.038565,"twenty":-19.665059,"median":-7.54679,"eighty":45.152187,"marketCap":7385944686},{"date":"2024-01-12","current":-18.763892,"twenty":-19.458602,"median":-7.54679,"eighty":45.152187,"marketCap":7682931972},{"date":"2024-01-19","current":-17.747734,"twenty":-19.2678,"median":-7.544467,"eighty":45.157955,"marketCap":7266862827},{"date":"2024-01-26","current":-18.073605,"twenty":-19.134896,"median":-7.54679,"eighty":45.152187,"marketCap":7400291898},{"date":"2024-02-02","current":-17.859862,"twenty":-19.007278,"median":-7.54679,"eighty":45.152187,"marketCap":7312773905},{"date":"2024-02-09","current":-17.512966,"twenty":-18.941814,"median":-7.54679,"eighty":45.152187,"marketCap":7170736507},{"date":"2024-02-16","current":-15.866089,"twenty":-18.881956,"median":-7.54679,"eighty":45.152187,"marketCap":6496417548},{"date":"2024-02-23","current":-17.500434,"twenty":-18.811317,"median":-7.54679,"eighty":45.152187,"marketCap":6410164032},{"date":"2024-03-01","current":-17.989873,"twenty":-18.791838,"median":-7.578157,"eighty":45.146419,"marketCap":6589438742},{"date":"2024-03-08","current":-17.774998,"twenty":-18.791838,"median":-7.603716,"eighty":45.146419,"marketCap":6510732771},{"date":"2024-03-15","current":-16.784182,"twenty":-18.791838,"median":-7.673842,"eighty":45.146419,"marketCap":6147810797},{"date":"2024-03-22","current":-17.010995,"twenty":-18.791838,"median":-7.777023,"eighty":45.146419,"marketCap":6230889321},{"date":"2024-03-28","current":-17.771018,"twenty":-18.791838,"median":-7.81825,"eighty":45.146419,"marketCap":6509275254},{"date":"2024-04-05","current":-17.042828,"twenty":-18.796083,"median":-7.904612,"eighty":45.152187,"marketCap":6242549465},{"date":"2024-04-12","current":-16.911516,"twenty":-18.796083,"median":-8.182691,"eighty":45.152187,"marketCap":6194451372},{"date":"2024-04-19","current":-16.239034,"twenty":-18.796083,"median":-8.560117,"eighty":45.152187,"marketCap":5948130835},{"date":"2024-04-26","current":-16.659633,"twenty":-18.791838,"median":-8.646128,"eighty":45.146419,"marketCap":6102190447},{"date":"2024-05-03","current":-17.157352,"twenty":-18.791838,"median":-8.845112,"eighty":45.146419,"marketCap":6284497762},{"date":"2024-05-10","current":-14.961134,"twenty":-18.791838,"median":-9.293144,"eighty":45.146419,"marketCap":5756535778},{"date":"2024-05-17","current":-14.25989,"twenty":-18.791838,"median":-9.334225,"eighty":45.146419,"marketCap":5486720952},{"date":"2024-05-24","current":-14.40393,"twenty":-18.791838,"median":-9.552464,"eighty":45.146419,"marketCap":5542142376},{"date":"2024-05-31","current":-13.854306,"twenty":-18.791838,"median":-9.739892,"eighty":45.146419,"marketCap":5330665890},{"date":"2024-06-07","current":-15.112755,"twenty":-18.791838,"median":-9.90935,"eighty":45.146419,"marketCap":5814874119},{"date":"2024-06-14","current":-15.586568,"twenty":-18.796083,"median":-9.987659,"eighty":45.152187,"marketCap":5997181434},{"date":"2024-06-21","current":-15.469062,"twenty":-18.800329,"median":-10.068299,"eighty":45.157955,"marketCap":5951969220},{"date":"2024-06-28","current":-17.902568,"twenty":-18.809069,"median":-10.099656,"eighty":45.171414,"marketCap":6888299589},{"date":"2024-07-05","current":-17.284716,"twenty":-18.809069,"median":-10.146845,"eighty":45.171414,"marketCap":6650570851},{"date":"2024-07-12","current":-17.932892,"twenty":-18.809069,"median":-10.187925,"eighty":45.171414,"marketCap":6899967258},{"date":"2024-07-15","current":-18.194437,"twenty":-18.809069,"median":-10.208466,"eighty":45.171414,"marketCap":7000600896},{"date":"2024-08-02","current":-20.490271,"twenty":-18.868176,"median":-10.389456,"eighty":45.307924,"marketCap":7484809124},{"date":"2024-08-09","current":-18.992918,"twenty":-18.884076,"median":-10.451704,"eighty":45.307924,"marketCap":6946488933},{"date":"2024-08-16","current":-18.655115,"twenty":-18.884076,"median":-10.488762,"eighty":45.307924,"marketCap":6822940561},{"date":"2024-08-23","current":-19.004911,"twenty":-18.92096,"median":-10.554325,"eighty":45.307924,"marketCap":6950875266},{"date":"2024-08-30","current":-19.948361,"twenty":-18.942377,"median":-10.636992,"eighty":45.307924,"marketCap":7295933440},{"date":"2024-09-06","current":-19.248769,"twenty":-18.979477,"median":-10.675476,"eighty":45.307924,"marketCap":7040064031},{"date":"2024-09-13","current":-17.667381,"twenty":-18.992918,"median":-10.762419,"eighty":45.307924,"marketCap":6461685590},{"date":"2024-09-20","current":-18.408188,"twenty":-18.992918,"median":-10.826557,"eighty":45.307924,"marketCap":6732629014},{"date":"2024-09-27","current":-17.701837,"twenty":-18.992918,"median":-11.068858,"eighty":45.307924,"marketCap":6474287610},{"date":"2024-10-04","current":-16.284829,"twenty":-18.992918,"median":-11.242743,"eighty":45.307924,"marketCap":5956029551},{"date":"2024-10-11","current":-16.345127,"twenty":-18.992918,"median":-12.040191,"eighty":45.307924,"marketCap":5978083085},{"date":"2024-10-18","current":-16.577706,"twenty":-18.992918,"median":-13.03948,"eighty":45.307924,"marketCap":6063146718},{"date":"2024-10-25","current":-16.698302,"twenty":-18.992918,"median":-13.446915,"eighty":45.307924,"marketCap":6107253787},{"date":"2024-10-31","current":-16.909346,"twenty":-18.992918,"median":-13.562755,"eighty":45.307924,"marketCap":6184441157},{"date":"2024-11-08","current":-16.902216,"twenty":-18.995317,"median":-13.748329,"eighty":45.31946,"marketCap":6072729658},{"date":"2024-11-15","current":-16.383322,"twenty":-18.995317,"median":-13.840323,"eighty":45.31946,"marketCap":5878515995},{"date":"2024-11-22","current":-14.935534,"twenty":-18.995317,"median":-14.176174,"eighty":45.31946,"marketCap":5359033920},{"date":"2024-11-29","current":-15.723236,"twenty":-18.995317,"median":-14.25989,"eighty":45.31946,"marketCap":5641670064},{"date":"2024-12-06","current":-16.172094,"twenty":-18.995317,"median":-14.506273,"eighty":45.31946,"marketCap":5802725297},{"date":"2024-12-13","current":-16.286509,"twenty":-18.995317,"median":-14.813304,"eighty":45.31946,"marketCap":5843778591},{"date":"2024-12-20","current":-15.661628,"twenty":-18.995317,"median":-14.935534,"eighty":45.31946,"marketCap":5619564444},{"date":"2024-12-27","current":-15.98727,"twenty":-18.995317,"median":-15.08243,"eighty":45.31946,"marketCap":5736408436},{"date":"2025-01-03","current":-15.265577,"twenty":-18.995317,"median":-15.112755,"eighty":45.31946,"marketCap":5477456886},{"date":"2025-01-10","current":-15.005943,"twenty":-18.997715,"median":-15.244128,"eighty":45.330996,"marketCap":5384297486},{"date":"2025-01-17","current":-14.205039,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5096924424},{"date":"2025-01-24","current":-15.164364,"twenty":-18.997715,"median":-15.281457,"eighty":45.330996,"marketCap":5441140510},{"date":"2025-01-31","current":-14.662699,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5261137602},{"date":"2025-02-07","current":-14.359059,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5152188474},{"date":"2025-02-14","current":-13.35573,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4792182660},{"date":"2025-02-21","current":-11.446164,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":5196558396},{"date":"2025-02-28","current":-10.979464,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4983545602},{"date":"2025-03-07","current":-12.044139,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5466798509},{"date":"2025-03-14","current":-11.522308,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5229940998},{"date":"2025-03-21","current":-11.46277,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5202916987},{"date":"2025-03-28","current":-11.109046,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5042362567},{"date":"2025-04-04","current":-9.988335,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4533675297},{"date":"2025-04-11","current":-9.354433,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4245949060},{"date":"2025-04-17","current":-9.928797,"twenty":-18.997715,"median":-15.294658,"eighty":45.330996,"marketCap":4506651286},{"date":"2025-04-25","current":-10.356068,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":4700588308},{"date":"2025-05-02","current":-11.018739,"twenty":-19.000114,"median":-15.297336,"eighty":45.342533,"marketCap":5046935029},{"date":"2025-05-09","current":-11.380123,"twenty":-19.000114,"median":-15.297336,"eighty":45.26178,"marketCap":5212460492},{"date":"2025-05-16","current":-11.463519,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5250658676},{"date":"2025-05-23","current":-11.55734,"twenty":-19.000114,"median":-15.297336,"eighty":45.175259,"marketCap":5293631632},{"date":"2025-05-30","current":-11.626837,"twenty":-19.000114,"median":-15.297336,"eighty":45.007986,"marketCap":5325463452},{"date":"2025-06-06","current":-12.24536,"twenty":-19.000114,"median":-15.297336,"eighty":44.117786,"marketCap":5608766648},{"date":"2025-06-13","current":-12.377404,"twenty":-19.000114,"median":-15.297336,"eighty":-6.098308,"marketCap":5669247106},{"date":"2025-06-20","current":-12.860408,"twenty":-19.002512,"median":-15.301886,"eighty":-6.769341,"marketCap":5890478253},{"date":"2025-06-27","current":-13.82294,"twenty":-19.002512,"median":-15.301886,"eighty":-6.989146,"marketCap":6331348958},{"date":"2025-07-03","current":-14.941841,"twenty":-19.002512,"median":-15.301886,"eighty":-7.017492,"marketCap":6843841257},{"date":"2025-07-11","current":-14.7264,"twenty":-19.002512,"median":-15.301886,"eighty":-7.061175,"marketCap":6745162615},{"date":"2025-07-18","current":-14.653429,"twenty":-19.002512,"median":-15.301886,"eighty":-7.105786,"marketCap":6711739204},{"date":"2025-07-25","current":-14.646479,"twenty":-19.002512,"median":-15.301886,"eighty":-7.221033,"marketCap":6708556022},{"date":"2025-08-01","current":-25.541485,"twenty":-19.026904,"median":-15.342587,"eighty":-7.288415,"marketCap":6850635022},{"date":"2025-08-08","current":-24.394555,"twenty":-19.059439,"median":-15.406519,"eighty":-7.31955,"marketCap":6543009950},{"date":"2025-08-15","current":-25.464231,"twenty":-19.208439,"median":-15.476942,"eighty":-7.439444,"marketCap":6829914162},{"date":"2025-08-22","current":-25.693023,"twenty":-19.327123,"median":-15.573133,"eighty":-7.500784,"marketCap":6891279785},{"date":"2025-08-29","current":-25.32755,"twenty":-19.462842,"median":-15.656683,"eighty":-7.572814,"marketCap":6793254179},{"date":"2025-09-05","current":-35.269594,"twenty":-19.610183,"median":-15.723236,"eighty":-7.595584,"marketCap":9459869441},{"date":"2025-09-12","current":-38.056694,"twenty":-19.731561,"median":-15.763036,"eighty":-7.642541,"marketCap":10207414305},{"date":"2025-09-19","current":-36.689886,"twenty":-19.905803,"median":-15.876073,"eighty":-7.741966,"marketCap":9840814478},{"date":"2025-09-26","current":-37.420831,"twenty":-20.021346,"median":-16.03996,"eighty":-7.801291,"marketCap":10036865690},{"date":"2025-10-03","current":-40.647687,"twenty":-20.250766,"median":-16.203648,"eighty":-7.855354,"marketCap":10902360063},{"date":"2025-10-10","current":-41.758962,"twenty":-20.936243,"median":-16.267488,"eighty":-8.057965,"marketCap":11200421661},{"date":"2025-10-17","current":-43.422902,"twenty":-21.44548,"median":-16.302057,"eighty":-8.466659,"marketCap":11646717103},{"date":"2025-10-24","current":-42.489907,"twenty":-21.627284,"median":-16.365719,"eighty":-8.619683,"marketCap":11396472873},{"date":"2025-10-31","current":-46.865674,"twenty":-22.311833,"median":-16.491552,"eighty":-8.824572,"marketCap":12013640728},{"date":"2025-11-07","current":-46.821444,"twenty":-24.565703,"median":-16.551864,"eighty":-9.220997,"marketCap":12002302521},{"date":"2025-11-14","current":-44.129685,"twenty":-25.310911,"median":-16.577552,"eighty":-9.310347,"marketCap":11312291607},{"date":"2025-11-21","current":-46.202213,"twenty":-25.459477,"median":-16.623152,"eighty":-9.406991,"marketCap":11843567616},{"date":"2025-11-28","current":-52.274467,"twenty":-25.606854,"median":-16.659586,"eighty":-9.54788,"marketCap":13400141532},{"date":"2025-12-05","current":-51.693149,"twenty":-25.977676,"median":-16.714478,"eighty":-9.709339,"marketCap":13251125091},{"date":"2025-12-12","current":-50.00606,"twenty":-36.254884,"median":-16.738094,"eighty":-9.817591,"marketCap":12818653462},{"date":"2025-12-16","current":-50.397818,"twenty":-36.342835,"median":-16.749269,"eighty":-9.897883,"marketCap":12919077585}],"updateTime":1766004590972},"$inf$@#url:\"https://stock-news.skytigris.cn/v3/notice/important/events/list\",params:#symbol:\"IONS\",pageSize:20,pageCount:2,market:\"us\",,,undefined,":[{"items":[{"cdn_pdf":false,"hasAttachments":true,"id":"20231132","market":"us","labels":[],"media":"sec.gov","original_id":"AN195824425004364-IONS","pdf_url":"","pub_time":1759291200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000195824425004364/0001958244-25-004364-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000195824425004364/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4bAJYgMLU7nFvU1f","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-10-01 12:00","pubTimestamp":1759291200,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20230726","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000223-IONS","pdf_url":"","pub_time":1759291200000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000223/0001972481-25-000223-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000223/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE2ZMKMR3DBAizC7qw","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-10-01 12:00","pubTimestamp":1759291200,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20228403","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000222-IONS","pdf_url":"","pub_time":1759204800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000222/0001972481-25-000222-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000222/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE5vP1e345rn3wsKhw","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-30 12:00","pubTimestamp":1759204800,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20228355","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000221-IONS","pdf_url":"","pub_time":1759204800000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000221/0001972481-25-000221-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000221/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE2Lmoxb55vn4QdaEn","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-30 12:00","pubTimestamp":1759204800,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20192147","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125035634-IONS","pdf_url":"","pub_time":1758513600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125035634/0001140361-25-035634-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125035634/ef20055880_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20055880_ex99-1.htm","type":"EX-99.1","id":"NTFILEAZrSVqQJC91ii8Em","market":"us","size":16254},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125035634/ef20055880_8k.htm","primary":false,"translateUrl":"","linkName":"ef20055880_8k.htm","type":"8-K","id":"NTFILECjh42Ys16sVvCEba","market":"us","size":32335},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125035634/image001.jpg","primary":false,"translateUrl":"","linkName":"image001.jpg","type":"GRAPHIC","id":"NTFILE6ECQU9Mm9DECYNYZ","market":"us","size":5439}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-09-22 12:00","pubTimestamp":1758513600,"title_zh":"Form 8-K - Current report","summary_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20125559","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000194-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000194/0001972481-25-000194-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000194/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE7ChkyNqJk5TvMwA1","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20125396","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000193-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000193/0001972481-25-000193-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000193/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEAy9CApGS5uNtNSNc","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20125093","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000192-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000192/0001972481-25-000192-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000192/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEHE9FsJr2dNgYFtnS","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20124995","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000190-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000190/0001972481-25-000190-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000190/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE7gWgPikAXZmwZwLk","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20124992","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000191-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000191/0001972481-25-000191-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000191/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILERuJnWPmtCujeKWD1","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20124814","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000189-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000189/0001972481-25-000189-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000189/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE5XAZbQVXL6stqTZQ","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20124809","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000188-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000188/0001972481-25-000188-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000188/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE8hXfeEvd3sT6ZcrB","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20124582","market":"us","labels":[],"media":"sec.gov","original_id":"AN196922325000715-IONS","pdf_url":"","pub_time":1756872000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000196922325000715/0001969223-25-000715-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000196922325000715/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE4EHT8iupTiGgwitY","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-03 12:00","pubTimestamp":1756872000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20120850","market":"us","labels":[],"media":"sec.gov","original_id":"AN195824425004293-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000195824425004293/0001958244-25-004293-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000195824425004293/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEDrceaag75reCEorY","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20120556","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000187-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000187/0001972481-25-000187-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000187/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE73vbeXw7ebNnhk3n","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20120203","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000185-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000185/0001972481-25-000185-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000185/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE9Z2gHVaiMkg7ksGY","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20120187","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000184-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000184/0001972481-25-000184-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000184/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILE3bzrY5XeGY84jiKA","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20119859","market":"us","labels":[],"media":"sec.gov","original_id":"AN197248125000183-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000183/0001972481-25-000183-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000197248125000183/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILES6AqdB7doAL6sqFf","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20118159","market":"us","labels":[],"media":"sec.gov","original_id":"AN114036125033541-IONS","pdf_url":"","pub_time":1756785600000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 8-K - Current report","symbol":"IONS","title":"Form 8-K - Current report","titleType":"Major Issues Report","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000114036125033541/0001140361-25-033541-index.htm","us_notice_code":"Form 8-K","us_title_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"EXHIBIT 99.1","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125033541/ef20054942_ex99-1.htm","primary":true,"translateUrl":"","linkName":"ef20054942_ex99-1.htm","type":"EX-99.1","id":"NTFILE2Sqbx2zi5jTVXrW4","market":"us","size":30143},{"description":"8-K","seq":2,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125033541/ef20054942_8k.htm","primary":false,"translateUrl":"","linkName":"ef20054942_8k.htm","type":"8-K","id":"NTFILE6sfCTqeN6XYyyNxD","market":"us","size":42437},{"description":"","seq":6,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000114036125033541/image00001.jpg","primary":false,"translateUrl":"","linkName":"image00001.jpg","type":"GRAPHIC","id":"NTFILEAaxQsTetZk3T2cdh","market":"us","size":3513}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Major Issues Report","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Major Issues Report","pubTime":"2025-09-02 12:00","pubTimestamp":1756785600,"title_zh":"Form 8-K - Current report","summary_en":"Item 7.01: Regulation FD Disclosure;\nItem 8.01: Other Events;\nItem 9.01: Financial Statements and Exhibits","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0},{"cdn_pdf":false,"hasAttachments":true,"id":"20110263","market":"us","labels":[],"media":"sec.gov","original_id":"AN4853225000002-IONS","pdf_url":"","pub_time":1756440000000,"showTitleType":true,"size":0,"source":"sec_us","summary":"Form 144 - Report of proposed sale of securities","symbol":"IONS","title":"Form 144 - Report of proposed sale of securities","titleType":"Proposed Sale Of Securities","type":"usAnnouncement","url":"https://www.sec.gov/Archives/edgar/data/874015/000004853225000002/0000048532-25-000002-index.htm","us_notice_code":"Form 144","us_title_en":"Form 144 - Report of proposed sale of securities","is_important":0,"hasEarnInfos":false,"gpt_zh_title":"","gpt_en_title":"","attachments":[{"description":"","seq":1,"linkUrl":"https://www.sec.gov/Archives/edgar/data/874015/000004853225000002/xsl144X01/primary_doc.xml","primary":true,"translateUrl":"","linkName":"primary_doc.html","type":"144","id":"NTFILEAdNcToLNqbut2UAV","market":"us","size":0}],"type_name":"Transaction Related","type_name_en":"Transaction Related","titleTypeEn":"Proposed Sale Of Securities","us_type":"交易披露","us_type_zh":"交易披露","earn_infos":[],"event_type":"important_notice","event_name":"Proposed Sale Of Securities","pubTime":"2025-08-29 12:00","pubTimestamp":1756440000,"title_zh":"Form 144 - Report of proposed sale of securities","summary_en":"","summary_zh":"","notice_type":"","filling_tag":"","gpt_icon":0}],"pageSize":20,"totalPage":18,"pageCount":2,"totalSize":350,"code":"91000000","status":"200"}]}}