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Ionis Pharmaceuticals

77.65

-0.7200-0.92%

Volume:998.54K

Turnover:78.17M

Market Cap:12.58B

PE:-48.13

High:79.49

Open:78.75

Low:77.45

Close:78.37

52wk High:83.61

52wk Low:23.95

Shares:161.97M

Float Shares:161.00M

Volume Ratio:0.51

T/O Rate:0.62%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.6132

EPS(LYR):-3.0358

ROE:-40.04%

ROA:-5.68%

PB:20.35

PE(LYR):-25.58

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Overview Company News Filings

Ionis Pharmaceuticals Is Maintained at Outperform by RBC Capital

RBC Raises Price Target on Ionis Pharmaceuticals to $95 From $82, Keeps Outperform Rating

MT Newswires Live

Is It Too Late to Consider Ionis After Its 126% Surge in 2025?

Simply Wall St.

Ionis Pharmaceuticals Is Maintained at Outperform by Leerink Partners

Ionis Pharmaceuticals Inc : Leerink Partners Raises Target Price to $100 From $85

THOMSON REUTERS

Ionis Pharmaceuticals (IONS): Revisiting Valuation After a Strong 1-Year Share Price Surge

Simply Wall St.

Ionis Pharmaceuticals Is Maintained at Buy by B of A Securities

Ionis Pharmaceuticals Inc : Bofa Global Research Raises Price Objective to $97 From $86

THOMSON REUTERS

Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares

Pharvaris Pill Provides Rapid Relief In Patients With Rare Swelling Attacks, Data Shows

Benzinga_recent_news

FDA Grants Breakthrough Therapy Designation to Ionis Pharmaceuticals' Zilganersen for Alexander Disease

Ionis Receives U.S. FDA Breakthrough Therapy Designation for Zilganersen for Alexander Disease (Axd)

THOMSON REUTERS

Ionis Pharmaceuticals Inc - on Track to Submit Nda for Zilganersen in Q1 2026

THOMSON REUTERS

Ionis Pharmaceuticals (IONS): Valuation Perspective Following FDA Breakthrough Therapy Milestone for Olezarsen

Simply Wall St.

Ionis Pharmaceuticals Shares Reverse Premarket Course, Last Down 2.4%

THOMSON REUTERS

Ionis Pharmaceuticals Shares up 3.5% Premarket After Co Receives FDA Breakthrough Therapy Designation for Olezarsen for Shtg

THOMSON REUTERS

FDA Grants Breakthrough Therapy Designation to Ionis Pharmaceuticals' Olezarsen for Severe Hypertriglyceridemia

Ionis Pharmaceuticals Inc: on Track to Submit Supplemental New Drug Application by End of Year

THOMSON REUTERS

Ionis Receives U.S. FDA Breakthrough Therapy Designation for Olezarsen for Severe Hypertriglyceridemia (Shtg)

THOMSON REUTERS

Metagenomi to Present Preclinical Data Supporting New Collaboration Target of APOC3 with Ionis Pharmaceuticals at Upcoming Nature Conference

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Pharmaceuticals Is Maintained at Outperform by RBC Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2592919546","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592919546?lang=en_us&edition=fundamental","pubTime":"2025-12-17 23:12","pubTimestamp":1765984320,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 17, 2025 10:12 ET (15:12 GMT)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2592997989","title":"RBC Raises Price Target on Ionis Pharmaceuticals to $95 From $82, Keeps Outperform Rating","url":"https://stock-news.laohu8.com/highlight/detail?id=2592997989","media":"MT Newswires Live","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592997989?lang=en_us&edition=fundamental","pubTime":"2025-12-17 20:36","pubTimestamp":1765974961,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) has an average rating of overweight and mean price target 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you are wondering whether Ionis Pharmaceuticals is still worth considering after its huge run, or if the easy money has already been made, this breakdown is for you.\nThe stock has risen 125.9% year to date and is up 108.0% over the last year, even after a recent 0.6% slip over the past week and a 9.5% gain in the last month.\nThose gains have come alongside growing optimism around its antisense drug pipeline and partnerships with major pharma names, as investors reassess the long 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Pharmaceuticals Is Maintained at Outperform by Leerink Partners","url":"https://stock-news.laohu8.com/highlight/detail?id=2591621111","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2591621111?lang=en_us&edition=fundamental","pubTime":"2025-12-16 04:55","pubTimestamp":1765832100,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 15, 2025 15:55 ET (20:55 GMT)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2591645516","title":"Ionis Pharmaceuticals Inc : Leerink Partners Raises Target Price to $100 From $85","url":"https://stock-news.laohu8.com/highlight/detail?id=2591645516","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2591645516?lang=en_us&edition=fundamental","pubTime":"2025-12-15 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A 1 year total shareholder return of 107.58 percent and 3 year total shareholder...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-revisiting-valuation-after-a-stro","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-revisiting-valuation-after-a-stro","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2590473325","title":"Ionis Pharmaceuticals Is Maintained at Buy by B of A Securities","url":"https://stock-news.laohu8.com/highlight/detail?id=2590473325","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590473325?lang=en_us&edition=fundamental","pubTime":"2025-12-10 02:09","pubTimestamp":1765303740,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 09, 2025 13:09 ET (18:09 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"gpt_icon":0},{"id":"2590343259","title":"Ionis Pharmaceuticals Inc : Bofa Global Research Raises Price Objective to $97 From $86","url":"https://stock-news.laohu8.com/highlight/detail?id=2590343259","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590343259?lang=en_us&edition=fundamental","pubTime":"2025-12-09 20:04","pubTimestamp":1765281856,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251209:nFWN3XF0FP:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588078114","title":"Ionis Pharmaceuticals Director Joseph H. Wender Reports Sale of Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2588078114","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588078114?lang=en_us&edition=fundamental","pubTime":"2025-12-04 08:01","pubTimestamp":1764806491,"startTime":"0","endTime":"0","summary":"Joseph H. Wender, Director at Ionis Pharmaceuticals Inc., reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 03, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251204:nNDL9wqt8r:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Ionis Pharmaceuticals Director Joseph H. 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This designation is granted to therapies that treat serious or life-threatening conditions and have shown preliminary clinical evidence of substantial improvement over existing treatments. Zilganersen demonstrated statistically significant and clinically meaningful results in a pivotal study, including stabilization of gait speed in affected patients. Ionis plans to submit a New Drug Application  to the FDA in the first quarter of 2026 and is preparing to initiate an Expanded Access Program in the U.S. There are currently no approved disease-modifying treatments for Alexander disease.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purpos","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nNDL2QRdNf:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588308940","title":"Ionis Receives U.S. FDA Breakthrough Therapy Designation for Zilganersen for Alexander Disease (Axd)","url":"https://stock-news.laohu8.com/highlight/detail?id=2588308940","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588308940?lang=en_us&edition=fundamental","pubTime":"2025-12-02 20:00","pubTimestamp":1764676801,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nTUA30VGRD:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588103087","title":"Ionis Pharmaceuticals Inc - on Track to Submit Nda for Zilganersen in Q1 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2588103087","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588103087?lang=en_us&edition=fundamental","pubTime":"2025-12-02 20:00","pubTimestamp":1764676801,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251202:nTUA30VGRD:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2588365770","title":"Ionis Pharmaceuticals (IONS): Valuation Perspective Following FDA Breakthrough Therapy Milestone for Olezarsen","url":"https://stock-news.laohu8.com/highlight/detail?id=2588365770","media":"Simply Wall St.","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588365770?lang=en_us&edition=fundamental","pubTime":"2025-12-02 01:18","pubTimestamp":1764609525,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) stock caught a fresh wave of attention after the FDA granted Breakthrough Therapy designation to its drug candidate olezarsen for severe hypertriglyceridemia. This regulatory milestone represents a key step for the company's pipeline.\nSee our latest analysis for Ionis Pharmaceuticals.\nIonis shares have surged amid a string of upbeat headlines, most notably the FDA's fast-track recognition for olezarsen and recent regulatory wins in Europe for their hereditary...","market":"us","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice2-main-header/1585186599552"],"rights":{"source":"simplywall_highlight","url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-valuation-perspective-following-f","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-ions/ionis-pharmaceuticals/news/ionis-pharmaceuticals-ions-valuation-perspective-following-f","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588775169","title":"Ionis Pharmaceuticals Shares Reverse Premarket Course, Last Down 2.4%","url":"https://stock-news.laohu8.com/highlight/detail?id=2588775169","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588775169?lang=en_us&edition=fundamental","pubTime":"2025-12-01 22:34","pubTimestamp":1764599698,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nFWN3X70NE:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2588722884","title":"Ionis Pharmaceuticals Shares up 3.5% Premarket After Co Receives FDA Breakthrough Therapy Designation for Olezarsen for Shtg","url":"https://stock-news.laohu8.com/highlight/detail?id=2588722884","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588722884?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:05","pubTimestamp":1764590744,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nFWN3X70MF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588724702","title":"FDA Grants Breakthrough Therapy Designation to Ionis Pharmaceuticals' Olezarsen for Severe Hypertriglyceridemia","url":"https://stock-news.laohu8.com/highlight/detail?id=2588724702","media":"Reuters","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588724702?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:01","pubTimestamp":1764590470,"startTime":"0","endTime":"0","summary":"Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Ionis Pharmaceuticals Inc. published the original content used to generate this news brief via Business Wire  on December 01, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nNDL17HMR5:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588724216","title":"Ionis Pharmaceuticals Inc: on Track to Submit Supplemental New Drug Application by End of Year","url":"https://stock-news.laohu8.com/highlight/detail?id=2588724216","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588724216?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nTUA91LG5Z:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588240724","title":"Ionis Receives U.S. FDA Breakthrough Therapy Designation for Olezarsen for Severe Hypertriglyceridemia (Shtg)","url":"https://stock-news.laohu8.com/highlight/detail?id=2588240724","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588240724?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251201:nTUA91LG5Z:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2588722311","title":"Metagenomi to Present Preclinical Data Supporting New Collaboration Target of APOC3 with Ionis Pharmaceuticals at Upcoming Nature Conference","url":"https://stock-news.laohu8.com/highlight/detail?id=2588722311","media":"GlobeNewswire","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588722311?lang=en_us&edition=fundamental","pubTime":"2025-12-01 20:00","pubTimestamp":1764590400,"startTime":"0","endTime":"0","summary":"EMERYVILLE, Calif., Dec.  01, 2025  (GLOBE NEWSWIRE) -- Metagenomi, Inc. 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