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Ionis Pharmaceuticals

31.86

-1.7850-5.31%

Pre-market: 31.30-0.5600-1.76%04:17 EDT

Volume:1.96M

Turnover:63.48M

Market Cap:5.07B

PE:-10.63

High:33.67

Open:33.00

Low:31.80

Close:33.65

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Overview Company News Filings

Catalyst (CPRX) Soars 16.7%: Is Further Upside Left in the Stock?

Denali Therapeutics' Amyotrophic Lateral Sclerosis Misses Pivotal Trial, But Analyst Says It Was Expected

Analysts Offer Insights on Healthcare Companies: Ionis Pharmaceuticals (IONS) and Anteris Technologies Global Corp. (AVR)

Ionis Pharmaceuticals Inc : Bofa Global Research Cuts Price Objective to $65 From $66

THOMSON REUTERS

AstraZeneca Stock Down Almost 14% in 3 Months: Time to Sell?

Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic

Analysts Offer Insights on Healthcare Companies: 60 Degrees Pharmaceuticals, Inc. (SXTP), Ionis Pharmaceuticals (IONS) and Zura Bio (ZURA)

Investors Don't See Light At End Of Ionis Pharmaceuticals, Inc.'s (NASDAQ:IONS) Tunnel

Simply Wall St.

Analysts Conflicted on These Healthcare Names: Ionis Pharmaceuticals (IONS) and UnitedHealth (UNH)

U.S. RESEARCH ROUNDUP-Hershey, Paychex, Revvity

Intellia Crashes 60% in a Year: How Should You Play the Stock?

Ionis FDA approval a positive for Arrowhead, says H.C. Wainwright

Ionis Gets FDA Approval for Rare Disease Drug Tryngolza

FDA Approves Ionis Pharmaceuticals' Rare Genetic Disease Therapy to Lower High-Level Of Fat In Blood

BUZZ-Ionis Pharma rises as FDA approves genetic disorder drug

Ionis Pharmaceuticals reports FDA approval of Tryngolza

Ionis Pharmaceuticals Says FDA Approved Familial Chylomicronemia Syndrome Drug

MT Newswires Live

Ionis Pharmaceuticals trading resumes

BRIEF-Tryngolza (Olezarsen) Approved In U.S. As First-Ever Treatment For Adults Living With Familial Chylomicronemia Syndrome As An Adjunct To Diet

Tryngolza™ (Olezarsen) Approved in U.S. as First-Ever Treatment for Adults Living With Familial Chylomicronemia Syndrome as an Adjunct to Diet

THOMSON REUTERS

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Wall Street securities analysts revised their ratings and price targets on several U.S.-listed companies including Hershey, Paychex an","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241223:nL4N3NO0CZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LEN","LU0690374961.EUR","UNIT","BK4099","IE00BJJMRZ35.SGD","AADI","NBIX","PAYX","LU1430594728.SGD","HSY","BGS","LU0054578231.USD","RVTY","BK4567","FLO","LU0234570918.USD","VITL","BK1576","CVGW","KNF","LEGN","SJM","HK0000320264.USD","GB00B4QBRK32.GBP","IE00BZ9MQY76.HKD","LU1035775433.USD","LU0417517546.SGD","LU0109394709.USD","BK1141","LU0320765992.SGD","01548","IONS","WGO","IE00B19Z9Z06.USD","LW","LU0114720955.EUR","BK4139","IIPR","BK4079","HALO","IE00BJT1NW94.SGD","LU2089984988.USD","LU0128526141.USD","BK4588","PIPR","SYK","VRTX","REPL","MGPI","JLL"],"gpt_icon":0},{"id":"2493346473","title":"Intellia Crashes 60% in a Year: How Should You Play the Stock?","url":"https://stock-news.laohu8.com/highlight/detail?id=2493346473","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2493346473?lang=en_us&edition=fundamental","pubTime":"2024-12-21 01:57","pubTimestamp":1734717420,"startTime":"0","endTime":"0","summary":"Intellia Therapeutics, Inc. NTLA has put up a dismal performance in 2024. Shares of the company have plunged 60.4% compared with the industry’s decline of 13.7%. The deterioration was more pronounced in the past five months. The stock has also underperformed the sector and the S&P 500 Index during this time frame.Intellia is a leading clinical-stage gene editing company focused on developing innovative CRISPR-based therapies. While these innovative therapies have been in the spotlight following the FDA approval of a couple of these in late 2023, investors are disappointed by the recently released data from NTLA’s in vivo CRISPR-based therapies.The FDA recently granted Regenerative Medicine Advanced Therapy designation to nex-z for the treatment of hereditary transthyretin  amyloidosis with polyneuropathy .The observed data also depicted favorable trends across multiple markers of cardiac disease progression at month 12 compared to baseline in an AT","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/2ZuhDuDie_37lq4aVERX2Q--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4718122d03716403704541c667907c4e","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/2ZuhDuDie_37lq4aVERX2Q--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4718122d03716403704541c667907c4e"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/intellia-crashes-60-play-stock-175700418.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4588","BK4198","LU2106854487.HKD","BK4585","CRSP","LU1169589451.USD","IONS","LU1861559042.SGD","LU0889565916.HKD","LU2089984988.USD","LU0823416689.USD","LU0882574055.USD","LU2362541273.HKD","LU1169590202.USD","HAE","IE00B64QTZ34.USD","LU1974910355.USD","IE00BLDYK493.USD","LU2023250504.SGD","BK4139","LU0205193047.USD","LU2362540622.SGD","REGN","LU0109394709.USD","LU2362541513.USD","LU0012050646.USD","LU0205194284.USD","LU0114720955.EUR","LU0053666078.USD","NTLA","LU1917777945.USD","LU0106261612.USD","LU1861558580.USD","LU0058720904.USD","BK4556","BK4535","LU2468319806.SGD","LU0289739699.SGD","LU0320765992.SGD"],"gpt_icon":1},{"id":"2492344451","title":"Ionis FDA approval a positive for Arrowhead, says H.C. Wainwright","url":"https://stock-news.laohu8.com/highlight/detail?id=2492344451","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492344451?lang=en_us&edition=fundamental","pubTime":"2024-12-20 22:26","pubTimestamp":1734704788,"startTime":"0","endTime":"0","summary":"H.C. Wainwright analyst Patrick Trucchio believes the FDA approval of Ionis Pharmaceuticals’ (IONS) Tryngolza, an oligonucleotide, for the treatmen...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-fda-approval-a-positive-for-arrowhead-says-h-c-wainwright?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-fda-approval-a-positive-for-arrowhead-says-h-c-wainwright?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2492428631","title":"Ionis Gets FDA Approval for Rare Disease Drug Tryngolza","url":"https://stock-news.laohu8.com/highlight/detail?id=2492428631","media":"Zacks","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492428631?lang=en_us&edition=fundamental","pubTime":"2024-12-20 21:03","pubTimestamp":1734699780,"startTime":"0","endTime":"0","summary":"Shares of Ionis Pharmaceuticals IONS rose nearly 5% in after-market trading on Thursday after the FDA approved its RNA-targeted therapy, olezarsen, in adults with familial chylomicronemia syndrome . The drug will be marketed under the trade name Tryngolza.The FDA’s nod to Tryngolza makes it the first approved treatment for FCS in the country. The drug’s commercial launch is part of management's broad strategy to deliver a steady flow of wholly-owned medicines to patients. Besides being Ionis’ first wholly-owned drug, Tryngolza marks the company’s first independent commercial launch, expected before this year’s end.The approval is supported by results from the phase III BALANCE study, where FCS patients treated with olezarsen achieved significant triglyceride-lowering and substantial reductions in acute pancreatitis attacks in FCS patients. A regulatory filing for the drug is currently under review by the EMA, also supported by data from this study.","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/Dt_k3wuw8zFeIe7BD2dBRA--~B/aD02MDA7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/5b7da1bf511604b75d7c8a64acb508f4","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/Dt_k3wuw8zFeIe7BD2dBRA--~B/aD02MDA7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/5b7da1bf511604b75d7c8a64acb508f4"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/ionis-gets-fda-approval-rare-130300731.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0012050646.USD","LU0234570918.USD","IE00BLDYK493.USD","BK4533","LU1829250122.USD","LU0320765992.SGD","LU1169590202.USD","BK4532","BK4198","HAE","IONS","LU2417539215.USD","BK4568","LU0109394709.USD","LU1169589451.USD","BK4007","LU2456880835.USD","AZN","LU0205194284.USD","GSK.UK","BK4588","CHB","IE00B894F039.SGD","BIIB","LU0889565916.HKD","LU0205193047.USD","GSK","LU0106261612.USD","BK4139","IE00B64QTZ34.USD","BK4585","LU2236285917.USD","LU2462157665.USD","IE00B19Z9Z06.USD","IE00B19Z9P08.USD"],"gpt_icon":0},{"id":"2492178264","title":"FDA Approves Ionis Pharmaceuticals' Rare Genetic Disease Therapy to Lower High-Level Of Fat In Blood","url":"https://stock-news.laohu8.com/highlight/detail?id=2492178264","media":"Benzinga","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492178264?lang=en_us&edition=fundamental","pubTime":"2024-12-20 20:24","pubTimestamp":1734697483,"startTime":"0","endTime":"0","summary":"SHTG isa condition where the level of triglycerides  in the blood is more than three times the normal level.The FDA approval was based on Phase 3 Balance trial data in adult patients.In the Balance study, Tryngolza 80 mg demonstrated a statistically significant placebo-adjusted mean reduction in triglyceride levels of 42.5% from baseline to six months .Reductions from baseline to 12 months were further improved, with Tryngolza achieving a placebo-adjusted 57% mean triglyceride reduction.Tryngolza also demonstrated a substantial, clinically meaningful reduction in AP events over 12 months; one patient (5%) experienced one episode of AP in the Tryngolza group compared with seven patients (30%) who experienced 11 total episodes of AP in the placebo group.Tryngolza will be available in the U.S. before year end.In November, Ionis Pharmaceuticals announced the pivotal Phase 3 study design following alignment with the FDA on ION582 for Angelman syndrome . The trial is expected to start in the","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/O8ruVFTE_OfGE.Eo_ZUo9w--~B/aD01NTM7dz05ODM7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/Benzinga/37254c50c996995ed7a1daeeedfee753","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/O8ruVFTE_OfGE.Eo_ZUo9w--~B/aD01NTM7dz05ODM7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/Benzinga/37254c50c996995ed7a1daeeedfee753"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/fda-approves-ionis-pharmaceuticals-rare-122443485.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["AP","BK4006","BK4202","GENE","BK4121","IONS","BK4139","AS"],"gpt_icon":0},{"id":"2492041143","title":"BUZZ-Ionis Pharma rises as FDA approves genetic disorder drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2492041143","media":"Reuters","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492041143?lang=en_us&edition=fundamental","pubTime":"2024-12-20 19:54","pubTimestamp":1734695648,"startTime":"0","endTime":"0","summary":"BUZZ-Ionis Pharma rises as FDA approves genetic disorder drug** Shares of drugmaker Ionis Pharmaceuticals IONS.O rise ~8% to $38.43 premarket** On Thursday, IONS said the U.S. FDA approved co's genetic disorder drug, olezarsen, to treat familial chylomicronemia syndrome ** FCS is a condition that prevents the body from breaking down fats and is characterized by extremely high levels of triglycerides** Brokerage TD Cowen forecasts peak sales of $82 mln in FY32 for FCS market** 17 of 25 brokerages rate the stock \"buy\" or higher, 7 \"hold\" and 1 \"sell\"; their median PT is $62 - LSEG** As of last close, stock has fallen 29.7% YTD  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Administration (FDA) has approved Tryngolza as an adjunct to diet to reduce trig...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-reports-fda-approval-of-tryngolza?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-reports-fda-approval-of-tryngolza?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139"],"gpt_icon":0},{"id":"2492494762","title":"Ionis Pharmaceuticals Says FDA Approved Familial Chylomicronemia Syndrome Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2492494762","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492494762?lang=en_us&edition=fundamental","pubTime":"2024-12-20 17:36","pubTimestamp":1734687388,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals (IONS) said late Thursday the US Food and Drug Administration has approved Tryngolza as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia 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financ...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-trading-resumes?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-trading-resumes?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","IONS"],"gpt_icon":0},{"id":"2492435000","title":"BRIEF-Tryngolza (Olezarsen) Approved In U.S. As First-Ever Treatment For Adults Living With Familial Chylomicronemia Syndrome As An Adjunct To 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