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ITT Inc.

149.41

+6.244.36%

Post-market: 149.410.00000.00%16:20 EDT

Volume:499.21K

Turnover:74.49M

Market Cap:11.76B

PE:23.79

High:150.04

Open:148.13

Low:147.50

Close:143.17

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Overview Company News Filings

IMNN: Protocol in Place for Phase 3 Trial of IMNN-001 in Ovarian Cancer…

Zacks Small Cap Research

Candel Therapeutics Reports Both Prolonged Median Overall Survival and Long Tail of Survival in Phase 2a Clinical Trial of CAN-2409 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Non-Responsive to Immune Checkpoint Inhibitor (ICI) Treatment

IMUNON Finalizes Phase 3 Study Design with FDA for IMNN-001 in Newly Diagnosed Advanced Ovarian Cancer

Pharma Stock Roundup: RHHBY Obesity Drug Rights Buyout, NVO Pipeline Update

Arvinas and Pfizer Announce Positive Topline Results from Phase 3 VERITAC-2 Clinical Trial

TEVIMBRA Approved in U.S. for First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma in Combination with Chemotherapy

IMNN: Phase 3 Ovarian Cancer Trial to get Underway in Mar 2025…

Zacks Small Cap Research

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Trial sites are currently being initiated with the first patient to be enrolled in the near term.The following slide provides the overall design of the trial. Eligible patients will have either Stage IIIc and IV advanced ovarian cancer and will be randomized to receive neoadjuvant chemotherapy , interval debulking surgery, and adjuvant chemotherapy. Patients who are positive for homologous recombination deficiency  are also eligible and will receive poly ADP-ribose polymerase  inhibitor therapy as part of standard-of-care  maintenance therapy. The primary endpoint is overall survival , with secondary endpoints evaluating surgical response score, chemotherapy response score, clinical response , and time to second-line treatment.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/imnn-protocol-place-phase-3-141900552.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IMNN","BK4161","BK4213","SOC","LU0054578231.USD","BK4225","LU0053671581.USD","OS","HR","BK4097","ORR","BK4139","ITT","GSD","BK4203"],"gpt_icon":0},{"id":"2522534823","title":"Candel Therapeutics Reports Both Prolonged Median Overall Survival and Long Tail of Survival in Phase 2a Clinical Trial of CAN-2409 in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Non-Responsive to Immune Checkpoint Inhibitor (ICI) Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2522534823","media":"GlobeNewswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2522534823?lang=en_us&edition=fundamental","pubTime":"2025-03-27 04:05","pubTimestamp":1743019500,"startTime":"0","endTime":"0","summary":"Experimental treatment with CAN-2409 was associated with a median overall survival  of 24.5 months in patients with advanced NSCLC who had an inadequate response to ICI treatment, failed several chemotherapy regimens, and presented with multiple negative prognostic factors at enrollment . mOS of 21.5 months was observed in patients with progressive disease at baseline despite ICI therapy , markedly exceeding mOS which has been reported in published literature for this population with standard of care of docetaxel chemotherapy . Long tail of survival observed in 37%  of patients with progressive disease despite ICI treatment at enrollment, who were still alive more than 2 years after CAN-2409 administration at the time of data cutoff ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/candel-therapeutics-reports-both-prolonged-200500872.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CADL","ITT","BK4600","IE00B19Z4B17.USD","LU0054578231.USD","BK4539","BK4588","BK4161","LU0053666078.USD","BK4157","BK4526","BK4585","BK4170","BK4595","IE0031619046.USD","IE00B7SZL793.SGD","BK4107","AEIS","BK4139","LU0053671581.USD","IE00B66KJ199.SGD","LENZ","L"],"gpt_icon":1},{"id":"2521747447","title":"IMUNON Finalizes Phase 3 Study Design with FDA for IMNN-001 in Newly Diagnosed Advanced Ovarian Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2521747447","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2521747447?lang=en_us&edition=fundamental","pubTime":"2025-03-24 20:00","pubTimestamp":1742817600,"startTime":"0","endTime":"0","summary":"First and only immunotherapy to show meaningful overall survival benefit in a Phase 2 trial in patients with advanced ovarian cancer Initiation of trial sites underway for ground-breaking Phase 3 pivo","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2025/03/24/3047774/0/en/IMUNON-Finalizes-Phase-3-Study-Design-with-FDA-for-IMNN-001-in-Newly-Diagnosed-Advanced-Ovarian-Cancer.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","IE00BKVL7J92.USD","IE00B7SZL793.SGD","ITT","LU0971096721.USD","CMC","BK4161","LU0170899867.USD","BK4157","IE00BZ1G4Q59.USD","LU0053671581.USD","LU0149725797.USD","IE0031619046.USD","IE00BHPRN162.USD","LU1363072403.SGD","IE00B66KJ199.SGD","IMNN","LU0267386448.USD","BK4097","LU0882574139.USD","OS","LU0054578231.USD","IE00B1BXHZ80.USD","BK4006","AEIS","IE00B19Z4B17.USD"],"gpt_icon":0},{"id":"2519863822","title":"Pharma Stock Roundup: RHHBY Obesity Drug Rights Buyout, NVO Pipeline Update","url":"https://stock-news.laohu8.com/highlight/detail?id=2519863822","media":"Zacks","labels":["merge"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2519863822?lang=en_us&edition=fundamental","pubTime":"2025-03-14 01:05","pubTimestamp":1741885500,"startTime":"0","endTime":"0","summary":"This week, Novo Nordisk NVO announced disappointing data from a phase III study on a novel obesity candidate, CagriSema. Roche RHHBY announced a license and collaboration deal with Denmark’s Zealand Pharma to co-develop its lead obesity candidate petrelintide. Pfizer PFE and partner Arvinas ARVN announced mixed phase III data for breast cancer therapy, vepdegestrant. J&J JNJ and partner Protagonist Therapeutics’ investigational targeted oral peptide, icotrokinra met the primary endpoint of clinical response in ulcerative colitis study.Here's a recap of the week’s most important stories.NVO's Novel Obesity Treatment Disappoints in Phase III Study. Novo Nordisk’sphase III REDEFINE 2 study evaluating its next-gen subcutaneous obesity candidate, CagriSema, met its primary endpoint. CagriSema is a fixed-dose combination of a long-acting amylin analog, cagrilintide  and semaglutide .In the study, 61.9% of patients were given the highest dose of the drug.For the deal, Roche will make an upfro","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/pharma-stock-roundup-rhhby-obesity-170500925.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"merge","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU1032466523.USD","BK4007","IE00B19Z3581.USD","BK4581","LU0054578231.USD","MBC","LU0345769631.USD","LU1718418525.SGD","ZLDPF","LU1244550221.USD","SG9999003800.SGD","PFE","BK4599","LU2129689605.HKD","IE00BGHQF631.EUR","NVO","IE00B4R5TH58.HKD","BK4559","ITT","03165","JNJ","LU0234570918.USD","LU1093756168.USD","IE00BDGV0183.EUR","ARVN","LU1732799900.SGD","LU1032955483.USD","SG9999001176.USD","LU2430703095.HKD","LU1066051811.HKD","LU2089984988.USD","LU1430594728.SGD","IE00BLSP4239.USD","SG9999011175.SGD","LU0466842654.USD","LU2505996509.AUD","IE00B42XCP33.USD","LU0912757837.SGD","RHHBY","LU0058720904.USD","SG9999002232.USD","LU0345770993.USD","LU1894683264.USD","LU2602419157.SGD","LU1261432733.SGD","LU0345769128.USD","LU0053671581.USD","LU0795875086.SGD","LU2112291526.USD","LU0225284248.USD"],"gpt_icon":1},{"id":"2518714832","title":"Arvinas and Pfizer Announce Positive Topline Results from Phase 3 VERITAC-2 Clinical Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2518714832","media":"GlobeNewswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518714832?lang=en_us&edition=fundamental","pubTime":"2025-03-11 18:45","pubTimestamp":1741689900,"startTime":"0","endTime":"0","summary":"– VERITAC-2 achieved its primary endpoint in the estrogen receptor 1-mutant population, demonstrating statistically significant and clinically meaningful improvement in progression-free survival – – V","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2025/03/11/3040386/0/en/Arvinas-and-Pfizer-Announce-Positive-Topline-Results-from-Phase-3-VERITAC-2-Clinical-Trial.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0289739699.SGD","LU0456855351.SGD","BK4007","LU0321505868.SGD","ITT","BK4599","BK4211","LU1066053197.SGD","SG9999003800.SGD","LU0306806265.USD","BK4592","LU0306807586.USD","LU1023059063.AUD","LU0985481810.HKD","LU0122379950.USD","LU0234572021.USD","BK4585","SG9999011175.SGD","LU0868494617.USD","BK4588","SG9999013999.USD","LU1883839398.USD","BK4534","BK4161","IE00BLSP4452.SGD","LU0170899867.USD","IE00B19Z3B42.SGD","IE00B19Z3581.USD","IE00BBT3K403.USD","LU0053671581.USD","LU1057294990.SGD","LU0058720904.USD","BK4581","PFS","SG9999001176.SGD","LU0321505439.SGD","SG9999002224.SGD","IE0002270589.USD","LU1066051498.USD","BK4195","BK4533","LU1894683348.USD","SGXZ57979304.SGD","BK4086","MBC","BK4550","PFE","IE00BLSP4239.USD","IE000M9KFDE8.USD","LU0054578231.USD"],"gpt_icon":1},{"id":"2516622921","title":"TEVIMBRA Approved in U.S. for First-line Treatment of Advanced Esophageal Squamous Cell Carcinoma in Combination with Chemotherapy","url":"https://stock-news.laohu8.com/highlight/detail?id=2516622921","media":"Business Wire","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2516622921?lang=en_us&edition=fundamental","pubTime":"2025-03-04 19:00","pubTimestamp":1741086000,"startTime":"0","endTime":"0","summary":"New indication based on results from a global Phase 3 trial demonstrating significantly improved overall survival benefit for PD-L1 positive patients treated with TEVIMBRA in combination with chemotherapy. SAN MATEO, Calif., March 04, 2025----BeiGene, Ltd. , a global oncology company that intends to change its name to BeOne Medicines Ltd., today announced the U.S. Food and Drug Administration  has approved TEVIMBRA , in combination with platinum-containing chemotherapy, for the first-line treatment of adults with unresectable or metastatic esophageal squamous cell carcinoma  whose tumors express PD-L1 (≥1).\"The approval of TEVIMBRA in combination with chemotherapy for adult patients with ESCC expands first-line treatment options for patients with this disease,\" said Dr. Nataliya Uboha, Associate Professor, University of Wisconsin, Carbone Cancer Center. \"There is a critical need for effective treatments of ESCC, and TEVIMBRA has been shown to improve outcomes in this patient population","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/tevimbra-approved-u-first-line-110000996.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["OS","L","BK4139","IE00B7SZL793.SGD","ITT","BK4588","AEIS","IE00B66KJ199.SGD","BK4144","IE0031619046.USD","BK4107","BK4585","LU0053666078.USD","LU0054578231.USD","LU0053671581.USD","BK4124","BK4161","ONC","BK4157","TEN","BK4097","IE00B19Z4B17.USD","HSCT"],"gpt_icon":0},{"id":"2514375360","title":"IMNN: Phase 3 Ovarian Cancer Trial to get Underway in Mar 2025…","url":"https://stock-news.laohu8.com/highlight/detail?id=2514375360","media":"Zacks Small Cap Research","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514375360?lang=en_us&edition=fundamental","pubTime":"2025-02-28 18:07","pubTimestamp":1740737220,"startTime":"0","endTime":"0","summary":"Imunon, Inc.  is continuing preparations to conduct a Phase 3 clinical trial of its lead development compound, IMNN-001, in patients with advanced ovarian cancer. IMNN-001 is a DNA immunotherapeutic drug that consists of an interleukin -12 expressing plasmid that allows for the durable, local, and targeted expression of IL-12 in the peritoneum. IL-12 is a potent pro-inflammatory cytokine that mediates a number of important cellular processes, including T cell and natural killer cell activation , the production of interferon-gamma , and alteration of myeloid-derived suppressor cells in the tumor microenvironment . While shown to be effective in pre-clinical tumor models, IL-12 therapy initially showed underwhelming results in the clinic along with very high levels of toxicity when administered systemically. This is likely due to the fact that the direct targets of IL-12 are not circulating lymphocytes, but rather immune cells located within the tumor and lymph nodes. Thus, while 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