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Purple Biotech Ltd.

2.27

+0.06983.17%

Volume:28.18K

Turnover:63.76K

Market Cap:6.16M

PE:-0.51

High:2.39

Open:2.19

Low:2.19

Close:2.20

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Overview Company News Filings

Purple Biotech Ltd expected to post a loss of $1.80 a share - Earnings Preview

Purple Biotech Reports Final Data from Phase 2 Study of CM24 in Pancreatic Cancer Patients at AACR 2025 Annual Meeting: Improved Outcomes and Significant Efficacy in Biomarker-Enriched Subgroups

Purple Biotech reports NT219 data at AACR meeting

Purple Biotech Reports Positive NT219 Data at AACR for Colorectal and Head and Neck Cancers

Purple Biotech Announces Publication in the Neuro Oncology Journal Demonstrating the Potential of NT219 to Suppress Brain Metastasis of Colorectal Cancer

Purple Biotech Q4 EPADS $(0.26)

Press Release: Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results

Purple Biotech Granted New U.S. Patent for NT219 in Combination with EGFR Antibody Therapy, Enhancing Global IP Protection in Major Markets

Purple Biotech Ltd expected to post a loss of $1.80 a share - Earnings Preview

Purple Biotech Moves NT219 Into Phase 2 Trial Aimed at Overcoming Tumor Resistance in Head, Neck Cancer Therapies

MT Newswires Live

Purple Biotech advances NT219 into Phase 2 head, neck cancer trial

Purple Biotech Advances NT219 into Phase 2 Head and Neck Cancer Trial

Purple Biotech Announces Research Collaboration with the Icahn School of Medicine at Mount Sinai for CAPTN-3 Tri-Specific Antibody Platform

Purple Biotech Secures $2.8 Million for Oncology Advancements

ADRs End Lower; Purple Biotech Ltd. Declines 27%

Purple Biotech Signs Securities Purchase Agreement

Purple Biotech Secures $2.8 Million Through ADS Offering

PPBT Stock Surges 150% on Superior Efficacy of PDAC Combo Therapy

ADRs Advance; Purple Biotech Ltd. Climbs 150%

Economic Data in Focus as US Equity Futures Waver Pre-Bell

MT Newswires Live

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The biomarkers identified in the Phase 2 study are planned to be used for patient selection in the next Phase 2b study. Prolongation of 2.4 months in OS HR=0.81  and prolongation of 1.9 months in PFS HR=0.75  vs. control arm","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-reports-final-data-110000531.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00BYTNYN87.SGD","BK4554","LU0359202008.SGD","BK4585","BK4124","BK4571","BK4588","BK4535","OS","LU2286300806.USD","SG9999011746.SGD","BK4565","BK4211","01698","BK4195","BK4563","TME","BK4531","BK4526","BK4613","BK4552","BK4560","PFS","BK4007","LU2039709279.SGD","CPS","BK4509","BK4097","LU0359201612.USD","IE00B12V2V27.USD","PPBT","BK4607","ORR","BK4108","IE00BYQNZ168.SGD","LU1023057109.AUD","NET","BK4116","BK4548"],"gpt_icon":0},{"id":"2530404968","title":"Purple Biotech reports NT219 data at AACR meeting","url":"https://stock-news.laohu8.com/highlight/detail?id=2530404968","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530404968?lang=en_us&edition=fundamental","pubTime":"2025-04-28 20:38","pubTimestamp":1745843926,"startTime":"0","endTime":"0","summary":"Purple Biotech (PPBT) announced that two posters reporting new NT219 data being presented at the American Association for Cancer Research Annual Me...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/purple-biotech-reports-nt219-data-at-aacr-meeting?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/purple-biotech-reports-nt219-data-at-aacr-meeting?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2530027654","title":"Purple Biotech Reports Positive NT219 Data at AACR for Colorectal and Head and Neck Cancers","url":"https://stock-news.laohu8.com/highlight/detail?id=2530027654","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2530027654?lang=en_us&edition=fundamental","pubTime":"2025-04-28 20:28","pubTimestamp":1745843280,"startTime":"0","endTime":"0","summary":"Activated b-catenin or loss of its negative regulator adenomatous polyposis coli  is a potential biomarker for NT219 in the treatment of colorectal cancer. NT219’s mechanism of action informs how it can restore efficacy of immunotherapies and expand the patient population that can benefit from immunotherapies. REHOVOT, Israel, April 28, 2025  -- Purple Biotech Ltd.  , a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance, announced today that two posters reporting new NT219 data being presented at the American Association for Cancer Research  Annual Meeting on Sunday and Monday, April 27-28, 2025.NT219, a novel dual inhibitor of IRS1/2 and STAT3, is being evaluated in a Phase 2 study in patients with recurrent and/or metastatic head and neck squamous cell cancer  in combination with pembrolizumab  and in combination with cetuximab .“These biomarker and mechanism data are important guides for study design, patient sel","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-reports-positive-nt219-122800847.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["APC","LU2420271590.USD","PPBT","LU2237443382.USD","LU0157215616.USD","LU1366192091.USD","LU0077335932.USD","BK4213","LU1496350171.SGD","LU2237443622.USD","CRC","LU1366333091.USD","BK4007","PDX","LU2417539215.USD","LU2237443978.SGD","LU2456880835.USD","LU2236285917.USD","LU2237443549.SGD","LU0266512127.USD","LU0456854461.SGD"],"gpt_icon":0},{"id":"2527829769","title":"Purple Biotech Announces Publication in the Neuro Oncology Journal Demonstrating the Potential of NT219 to Suppress Brain Metastasis of Colorectal Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2527829769","media":"GlobeNewswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2527829769?lang=en_us&edition=fundamental","pubTime":"2025-04-16 19:00","pubTimestamp":1744801200,"startTime":"0","endTime":"0","summary":"Findings show combination therapy of NT219 and 5-flourouracil  inhibits colorectal cancer brain metastasis through the IRS2 pathway. IRS2, a novel target of NT219, is identified as a driver of brain metastasis in colorectal cancer, by comprehensive research conducted by Prof. Wolf and Dr. Rubinek team at Tel Aviv University and Sourasky Medical Center. The study analyzed over 35,000 CRC samples, providing insight into the biology of CRC BM. The study identifies a distinct genomic profile associated with CRC BM, highlighting the possible role of IRS2 in promoting BM formation. Additionally, the study found that heightened levels of IRS2 expression are more prevalent and clinically significant phenomenon in CRC BM. At","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-announces-publication-neuro-110000242.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["PPBT"],"gpt_icon":0},{"id":"2518722912","title":"Purple Biotech Q4 EPADS $(0.26)","url":"https://stock-news.laohu8.com/highlight/detail?id=2518722912","media":"Benzinga","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518722912?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:58","pubTimestamp":1741611533,"startTime":"0","endTime":"0","summary":"Purple Biotech Q4 EPADS $(0.26)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/news/earnings/25/03/44218072/purple-biotech-q4-epads-0-26","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2518817229","title":"Press Release: Purple Biotech Reports Fourth Quarter and Full-Year 2024 Financial Results","url":"https://stock-news.laohu8.com/highlight/detail?id=2518817229","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518817229?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:57","pubTimestamp":1741611420,"startTime":"0","endTime":"0","summary":"Completed successful clinical trials for CM24 and NT219 oncology assets, demonstrating clinical benefits and identifying potential biomarkers. CM24 is well positioned for personalized treatment, with planned biomarker-driven Phase 2b study based on serum biomarkers CEACAM1 and myeloperoxidase. NT219 headed into Phase 2 head and neck cancer study in combination with pembrolizumab  and in combination with cetuximab . \"We believe that our CAPTN-3 platform is well-positioned and differentiated in the T cell engagers  and multi-specific space, uniquely unleashes both innate and adaptive immune cells against the tumor, demonstrating synergistic effect of the T cell and NK cell activating arms. The unique NKG2A arm in the lead compound acts as a checkpoint inhibitor, enabling simultaneous NK and T cell activation, including effector subsets with high antitumor activity. We are excited about our CAPTN-3 collaboration with the Icahn School of Medicine at Mount Sinai. Our cash runway is expected","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PFS","BK4211","ORR","PPBT","BK4007","BK4195","OS","BK4097"],"gpt_icon":0},{"id":"2517717913","title":"Purple Biotech Granted New U.S. Patent for NT219 in Combination with EGFR Antibody Therapy, Enhancing Global IP Protection in Major Markets","url":"https://stock-news.laohu8.com/highlight/detail?id=2517717913","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2517717913?lang=en_us&edition=fundamental","pubTime":"2025-03-05 20:00","pubTimestamp":1741176000,"startTime":"0","endTime":"0","summary":"NT219 in combination with EGFR antibody cetuximab  is currently entering a Phase 2 study for head and neck cancer. About Purple BiotechPurple Biotech Ltd.  is a clinical-stage company developing first-in-class therapies that seek to overcome tumor immune evasion and drug resistance. The Company's oncology pipeline includes CM24, NT219, and CAPTN-3. CM24 is a humanized monoclonal antibody that blocks CEACAM1, which supports tumor immune evasion and survival through multiple pathways. CEACAM1 on tumor cells, immune cells and neutrophil extracellular traps is a novel target for the treatment of multiple cancer indications. As proof of concept of these novel pathways, the Company completed a Phase 2 study for the treatment of pancreatic ductal adenocarcinoma  with CM24 as a combination therapy with the anti-PD-1 checkpoint inhibitor nivolumab and chemotherapy, demons","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-granted-u-patent-120000949.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4588","LU1481600234.SGD","PPBT","BK4136","LU1487256676.USD","BK4585","LU2463526074.USD","IP","LU1481599808.USD","BK4007"],"gpt_icon":0},{"id":"2514881324","title":"Purple Biotech Ltd  expected to post a loss of $1.80 a share - Earnings Preview","url":"https://stock-news.laohu8.com/highlight/detail?id=2514881324","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514881324?lang=en_us&edition=fundamental","pubTime":"2025-02-28 21:33","pubTimestamp":1740749589,"startTime":"0","endTime":"0","summary":"Purple Biotech Ltd  expected to post a loss of $1.80 a share - Earnings Preview Purple Biotech Ltd PPBT.OQ, PPBT.O is expected to show no change in quarterly revenue when it reports  results on March ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250228:nL5N3PJ1BA:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PPBT"],"gpt_icon":0},{"id":"2512157030","title":"Purple Biotech Moves NT219 Into Phase 2 Trial Aimed at Overcoming Tumor Resistance in Head, Neck Cancer Therapies","url":"https://stock-news.laohu8.com/highlight/detail?id=2512157030","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2512157030?lang=en_us&edition=fundamental","pubTime":"2025-02-18 21:41","pubTimestamp":1739886081,"startTime":"0","endTime":"0","summary":"Purple Biotech  said Tuesday it is advancing its drug candidate NT219 into a phase 2 clinical trial aimed at overcoming tumor resistance in therapies for recurring metastatic squamous cell cancer of the head and neck.The study will evaluate the safety and efficacy of NT219 in combination with standard therapies like pembrolizumab and cetuximab, focusing on overcoming the resistance mechanisms tumors develop against such treatments, the company said.Purple Biotech's shares were up over 10% in recent Tuesday premarket activity.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2512919151","title":"Purple Biotech advances NT219 into Phase 2 head, neck cancer trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2512919151","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2512919151?lang=en_us&edition=fundamental","pubTime":"2025-02-18 20:25","pubTimestamp":1739881519,"startTime":"0","endTime":"0","summary":"Purple Biotech (PPBT) is advancing into a Phase 2 study with NT219 in patients with recurrent/metastatic squamous cell carcinoma of the head and ne...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/purple-biotech-advances-nt219-into-phase-2-head-neck-cancer-trial?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/purple-biotech-advances-nt219-into-phase-2-head-neck-cancer-trial?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["PPBT","BK4007"],"gpt_icon":0},{"id":"2512151337","title":"Purple Biotech Advances NT219 into Phase 2 Head and Neck Cancer Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2512151337","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2512151337?lang=en_us&edition=fundamental","pubTime":"2025-02-18 20:00","pubTimestamp":1739880000,"startTime":"0","endTime":"0","summary":"NT219, a novel agent designed to overcome tumor resistance to drug therapy, will be evaluated in combination with the standard-of-care head and neck cancer drugs pembrolizumab  or cetuximab . The study is conducted in collaboration with the University of Colorado Anschutz Medical Campus and is led by Dr. Antonio Jimeno, Professor and Director of the Head and Neck Cancer Program. Dr. Jimeno focuses his research on achieving durable tumor control for head and neck cancers , with an in-depth view of the cancer and immune cell interaction. He recently demonstrated the central role of STAT3 in the PD1-PDL1 axis and tumor clonogenicity, motility, invasion, as well as resistance to immunotherapy, radiation and chemotherapy.Dr. Jimeno commented, “NT219 is a novel and unique compound inhi","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-advances-nt219-phase-120000411.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2508128791","title":"Purple Biotech Announces Research Collaboration with the Icahn School of Medicine at Mount Sinai for CAPTN-3 Tri-Specific Antibody Platform","url":"https://stock-news.laohu8.com/highlight/detail?id=2508128791","media":"GlobeNewswire","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2508128791?lang=en_us&edition=fundamental","pubTime":"2025-02-03 20:00","pubTimestamp":1738584000,"startTime":"0","endTime":"0","summary":"Collaboration to explore the immunoregulation of NK and T cells within thetumor microenvironment  by CAPTN-3, with the goal of enhancing tumor-specific immunity against multiple cancer types.CAPTN-3 antibodies are designed to promote innate-like antitumor functions by NK and CD8 T cells, through conditional activation of the anti-CD3 arm at the TME, blockade of NKG2A, and targeting tumor-specific antigens, potentially leading to improved responses in resistant cancer patients andovercoming the limitations of current therapies.REHOVOT, Israel, Feb. 03, 2025  -- Purple Biotech Ltd.  , a clinical-stage company developing first-in-class therapies that overcome tumor immune evasion and drug resistance, announced today that it has entered into a Research Collaboration Agreement with the Icahn School of Medicine at Mount Sinai  in New York, NY, to explore the immunoregulation of NK and T cells within the TME by Purple’s CAPTN-3 multi-specific engagers with the purpose of enhancing tumor-speci","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/purple-biotech-announces-research-collaboration-120000171.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4548","BK4563","BK4007","BK4571","IE00B12V2V27.USD","LU0359202008.SGD","BK4509","PPBT","BK4531","BK4535","BK4108","BK4526","IE00BYTNYN87.SGD","BK4552","TME","LU0359201612.USD","IE00BYQNZ168.SGD","LU1023057109.AUD","01698","LU2039709279.SGD","BK4565","SG9999011746.SGD"],"gpt_icon":0},{"id":"2489745523","title":"Purple Biotech Secures $2.8 Million for Oncology Advancements","url":"https://stock-news.laohu8.com/highlight/detail?id=2489745523","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489745523?lang=en_us&edition=fundamental","pubTime":"2024-12-05 20:47","pubTimestamp":1733402840,"startTime":"0","endTime":"0","summary":"Purple Biotech (PPBT) has released an update. Purple Biotech has successfully closed a $2.8 million registered direct offering of American Deposita...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/purple-biotech-secures-2-8-million-for-oncology-advancements?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/purple-biotech-secures-2-8-million-for-oncology-advancements?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2489140283","title":"ADRs End Lower; Purple Biotech Ltd. Declines 27%","url":"https://stock-news.laohu8.com/highlight/detail?id=2489140283","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489140283?lang=en_us&edition=fundamental","pubTime":"2024-12-05 05:31","pubTimestamp":1733347860,"startTime":"0","endTime":"0","summary":"This article was automatically generated by Dow Jones using technology from Automated Insights.International stocks trading in New York closed lower on Wednesday, as the S&P/BNY Mellon index of American depositary receipts fell 0.2% to 183.78.The European index dropped 0.2% to 168.52. The Asian index fell 0.1% to 236.58. The Latin American index fell 0.4% to 184.27, while the emerging-markets index gained 0.2% to 383.12.Purple Biotech Ltd., based in Israel, posted the largest decline, plummeting 27% to $4.82, followed by shares of Israel's Can-Fite Biopharma Ltd., which plummeted 20% to $1.59. Shares of United Kingdom-based Argo Blockchain PLC plunged 17% to 68 cents.China's Hesai Group was the biggest leader during the session, jumping 19% to $9.53, and Australia-based Alterity Therapeutics Ltd. jumped 17% to $1.88. iClick Interactive Asia Group Ltd., which is based in Hong Kong, rounded out the top three leaders on Wednesday, with shares jumping 16% to $5.58.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PPBT","BK4007"],"gpt_icon":1},{"id":"2489126371","title":"Purple Biotech Signs Securities Purchase Agreement","url":"https://stock-news.laohu8.com/highlight/detail?id=2489126371","media":"TIPRANKS","labels":["corporation"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489126371?lang=en_us&edition=fundamental","pubTime":"2024-12-05 00:58","pubTimestamp":1733331504,"startTime":"0","endTime":"0","summary":"Purple Biotech (PPBT) has released an update. Purple Biotech Ltd., an Israeli company, has entered into a Securities Purchase Agreement to issue an...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/purple-biotech-signs-securities-purchase-agreement?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/purple-biotech-signs-securities-purchase-agreement?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2488670971","title":"Purple Biotech Secures $2.8 Million Through ADS Offering","url":"https://stock-news.laohu8.com/highlight/detail?id=2488670971","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488670971?lang=en_us&edition=fundamental","pubTime":"2024-12-04 05:36","pubTimestamp":1733261805,"startTime":"0","endTime":"0","summary":"Purple Biotech (PPBT) has released an update. Purple Biotech has announced a $2.8 million registered direct offering of American Depositary Shares,...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/purple-biotech-secures-2-8-million-through-ads-offering?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/purple-biotech-secures-2-8-million-through-ads-offering?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","PPBT"],"gpt_icon":0},{"id":"2488921230","title":"PPBT Stock Surges 150% on Superior Efficacy of PDAC Combo Therapy","url":"https://stock-news.laohu8.com/highlight/detail?id=2488921230","media":"Zacks","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488921230?lang=en_us&edition=fundamental","pubTime":"2024-12-04 00:27","pubTimestamp":1733243220,"startTime":"0","endTime":"0","summary":"Purple BiotechPPBT, a clinical-stage oncology company, reported positive final results from the mid-stage study of its lead candidate, CM24, for treating pancreatic ductal adenocarcinoma  patients. CM24 is a humanized monoclonal antibody that blocks CEACAM1, supporting tumor immune evasion and survival through multiple pathways.Purple Biotech states that treatment with CM24 in the phase II study demonstrated a clear and consistent improvement across all efficacy endpoints. A potential patient subgroup was also identified which may benefit from targeting CEACAM1 and NET serum levels. Such findings have the potential to position CM24 as an encouraging treatment option. Shares of PPBT surged 150.4% on Monday in response to the news.The enrolled patients were randomly divided into two study cohorts, with two arms per cohort. In the experimental arms, second-line PDAC patients received CM24 and Bristol Myers’ Opdivo in combination with either gemcitabine/nab-paclitaxel or liposomal irinotec","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/QieiOVP5CdM1cfxTnlcVfQ--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/e797ee31d4bee954c41ecfac218dc795","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/QieiOVP5CdM1cfxTnlcVfQ--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/e797ee31d4bee954c41ecfac218dc795"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/ppbt-stock-surges-150-superior-162700046.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00BLSP4239.USD","LU2133065610.SGD","BMY","LU0889565916.HKD","BK4583","LU0882574055.USD","BK4211","GILD","BK4007","BK4532","LU0321505868.SGD","BK4588","SG9999013999.USD","BK4568","LU1883839398.USD","LU1066051498.USD","LU0306806265.USD","LU2360032135.SGD","PFE","IE00B19Z3B42.SGD","LU0868494617.USD","LU1291159041.SGD","BK4550","LU1718418525.SGD","LU2468319806.SGD","SGXZ57979304.SGD","LU1868836914.USD","IE00BZ1G4Q59.USD","LU0234570918.USD","LU1093756168.USD","PFS","OS","IE00B7SZLL34.SGD","LU0306807586.USD","LU1585245621.USD","LU1894683348.USD","IE00BBT3K403.USD","IE00BFTCPJ56.SGD","IE00BSNM7G36.USD","PPBT","LU0061475181.USD","LU0114720955.EUR","SG9999011175.SGD","LU2125154778.USD","LU0234572021.USD","LU2242652126.USD","IE00BKVL7J92.USD","SG9999001176.SGD","LU1670710661.SGD","BK4559"],"gpt_icon":1},{"id":"2488730986","title":"ADRs Advance; Purple Biotech Ltd. Climbs 150%","url":"https://stock-news.laohu8.com/highlight/detail?id=2488730986","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488730986?lang=en_us&edition=fundamental","pubTime":"2024-12-03 05:31","pubTimestamp":1733175060,"startTime":"0","endTime":"0","summary":"This article was automatically generated by Dow Jones using technology from Automated Insights.International stocks trading in New York closed higher on Monday, as the S&P/BNY Mellon index of American depositary receipts rose 1.1% to 182.61.The European index increased 0.3% to 167.84. The Asian index gained 2.3% to 234.30. The Latin American index dropped 0.3% to 183.90, while the emerging-markets index rose 2.1% to 378.26.Israel's Purple Biotech Ltd. was the biggest leader during the session, rocketing 150% to $8.40, and Australia-based Mobilicom Ltd. soared 30% to $2.41. Intchains Group Ltd., which is based in China, rounded out the top three leaders on Monday, with shares surging 15% to $5.11.Mynd.ai Inc., based in China, posted the largest decline, plunging 19% to $2.36, followed by shares of Hong Kong's iClick Interactive Asia Group Ltd., which plunged 16% to $5.92. Shares of United Kingdom-based Argo Blockchain PLC plunged 15% to 95 cents.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PPBT","BK4007"],"gpt_icon":1},{"id":"2488674799","title":"Economic Data in Focus as US Equity Futures Waver Pre-Bell","url":"https://stock-news.laohu8.com/highlight/detail?id=2488674799","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2488674799?lang=en_us&edition=fundamental","pubTime":"2024-12-02 22:13","pubTimestamp":1733148818,"startTime":"0","endTime":"0","summary":"US equity futures were flat before Monday's opening 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