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Cassava Sciences Inc

1.61

-0.0100-0.62%

Post-market: 1.60-0.0100-0.62%19:57 EDT

Volume:435.09K

Turnover:707.13K

Market Cap:77.78M

PE:-1.10

High:1.67

Open:1.64

Low:1.60

Close:1.62

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Overview Company News Filings

Sector Update: Health Care Stocks Higher Thursday Afternoon

MT Newswires Live

Cassava Sciences Licenses Simufilam Patent From Yale University for Potential Treatment of Seizures; Shares Rise

MT Newswires Live

Cassava Sciences licenses simufilam method of treatment patent

Cassava Sciences Inc - Company to Pay Yale up to $4.5 Million in Milestones

THOMSON REUTERS

Cassava Sciences Inc - Enters License Agreement With Yale University

THOMSON REUTERS

Cassava Sciences Inc - Granted Exclusive Worldwide Rights to Yale's Patent Interests

THOMSON REUTERS

Cassava Sciences Licenses Simufilam Method of Treatment Patent

Cassava Gears Up to Report Q4 Earnings: What's in the Cards?

Clinical trials site shows Cassava Sciences REFOCUS-ALZ trial terminated

Cassava Sciences to Reduce Staff, Halt Further Analysis

MT Newswires Live

BRIEF-Cassava Sciences Provides A Business Update

Cassava Sciences Inc: in Final Stages of Discontinuing Refocus-Alz Study

THOMSON REUTERS

Cassava Sciences Provides a Business Update

THOMSON REUTERS

Cassava- Topline Data From Phase 3 Refocus-Alz Study of Simufilam in Patients With Mild-to-Moderate Alzheimer's Disease Expected Late Q1/Early Q2 2025

THOMSON REUTERS

Cassava Sciences Inc: Implementing Cost Curtailment Including a Workforce Reduction of Approximately 33%

THOMSON REUTERS

Cassava Sciences Provides a Business Update

Lost Money on Cassava Sciences, Inc.(SAVA)? Join Class Action Suit Seeking Recovery – Contact Levi & Korsinsky LLP

Biotech Stock Roundup: BBIO Stock Up on Drug Approval, SAVA, APLT Plunge on Setbacks & More

A Post-Mortem on Cassava Sciences

SAVA Stock Plunges 84% on Alzheimer's Drug Failure in Late-Stage Study

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Walgreens shares advanced 5%.Cassava Sciences  shares jumped past 15%. The company said Thursday it has signed a license agreement with Yale University for intellectual property rights, including an exclusive US method of treatment patent covering simufilam as a potential treatment for seizures linked to rare neurodevelopmental disorders such as tuberous sclerosis complex.Viatris  shares dropped past 13% after it reported lower Q4 results, which also fell short of market expectations.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SAVA","WBA","LU0321505439.SGD","LU2087621335.USD","BK4583","BK4007","LU1839511570.USD","BK4581","BK4585","LU0321505868.SGD","BK4588","VTRS","IBB","WBA.AU","BK4547","BK4128","XLV"],"gpt_icon":0},{"id":"2514382913","title":"Cassava Sciences Licenses Simufilam Patent From Yale University for Potential Treatment of Seizures; Shares Rise","url":"https://stock-news.laohu8.com/highlight/detail?id=2514382913","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514382913?lang=en_us&edition=fundamental","pubTime":"2025-02-28 00:14","pubTimestamp":1740672845,"startTime":"0","endTime":"0","summary":"Cassava Sciences  said Thursday it has entered into a license agreement with Yale University for intellectual property rights, including an exclusive US method of treatment patent covering simufilam as a potential treatment for seizures linked to rare neurodevelopmental disorders such as tuberous sclerosis complex.The licensed patent is based on research and development carried out by a neurosurgery professor at Yale, which showed that Cassava's drug candidate, simufilam, reduced TSC-related seizure frequency in animal models.Shares of Cassava Sciences were up more than 12% in recent Thursday trading.Price: 2.58, Change: +0.28, Percent Change: +12.13","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4547","BK4585","BK4007","SAVA","BK4588"],"gpt_icon":0},{"id":"2514801521","title":"Cassava Sciences  licenses simufilam method of treatment patent","url":"https://stock-news.laohu8.com/highlight/detail?id=2514801521","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514801521?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:51","pubTimestamp":1740660692,"startTime":"0","endTime":"0","summary":"Cassava Sciences (SAVA) has entered into an agreement with Yale University for a license to intellectual property rights, including an exclusive li...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/cassava-sciences-licenses-simufilam-method-of-treatment-patent?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/cassava-sciences-licenses-simufilam-method-of-treatment-patent?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4585","SAVA","BK4547","BK4588","BK4007"],"gpt_icon":0},{"id":"2514809186","title":"Cassava Sciences Inc - 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Granted Exclusive Worldwide Rights to Yale's Patent Interests","url":"https://stock-news.laohu8.com/highlight/detail?id=2514099798","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514099798?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:36","pubTimestamp":1740659766,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250227:nFWN3PI1S1:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4547","BK4588","BK4007","SAVA","BK4585"],"gpt_icon":0},{"id":"2514805455","title":"Cassava Sciences Licenses Simufilam Method of Treatment Patent","url":"https://stock-news.laohu8.com/highlight/detail?id=2514805455","media":"GlobeNewswire","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2514805455?lang=en_us&edition=fundamental","pubTime":"2025-02-27 20:00","pubTimestamp":1740657600,"startTime":"0","endTime":"0","summary":"Cassava enters into a license agreement with Yale University granting intellectual property rights, including rights to an issued US method of treatment patent for potential treatment with simufilam of seizures related to rare neurodevelopmental disorders. The licensed patent is based on research led by Yale University and published in Science Translational Medicine showing that treatment with simufilam appeared to meaningfully reduce seizure frequency in an animal model. Cassava will prioritize initial development efforts on tuberous sclerosis complex -related seizures. The intellectual property that Cassava has licensed is based on the promising research and development work of Angélique Bordey, PhD, Professor of Neurosurgery and Vice Chair of Research, Neurosurgery at Yale, and her collaborators. In a paper published in Science Translational Medicine2 in 2020, the researchers showed that treatment with simufilam  appeared to meaningfully reduce TSC-related seizure frequency in an an","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/cassava-sciences-licenses-simufilam-method-120000627.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CNS","BK4588","BK4007","BK4135","SAVA","BK4585","BK4547","SAVAW"],"gpt_icon":0},{"id":"2513221890","title":"Cassava Gears Up to Report Q4 Earnings: What's in the Cards?","url":"https://stock-news.laohu8.com/highlight/detail?id=2513221890","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2513221890?lang=en_us&edition=fundamental","pubTime":"2025-02-21 23:37","pubTimestamp":1740152220,"startTime":"0","endTime":"0","summary":"Cassava SciencesSAVA, a clinical-stage biotech focusing on developing novel products to detect and treat neurodegenerative diseases, such as Alzheimer’s disease , is expected to report fourth-quarter earnings results soon.See the ZacksEarnings Calendar to stay ahead of market-making news.The Zacks Consensus Estimate for SAVA’s loss per share in the to-be-reported quarter is currently pegged at $1.58. The company currently does not generate any revenues.Let's see how things have shaped up for the upcoming quarterly release.In the absence of a marketed product, investors are advised to look forward to the company’s pipeline updates in the upcoming earnings call.Please note that in November 2024, Cassava faced a massive setback after it reported that its lead and only pipeline drug, simufilam, failed to meet the primary endpoints in a late study for AD.Cassava beat estimates in one of the trailing four quarters and missed on the other three occasions, delivering an average negative surpri","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/cassava-gears-report-q4-earnings-153700983.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["SAVA","SAVAW"],"gpt_icon":0},{"id":"2509523335","title":"Clinical trials site shows Cassava Sciences REFOCUS-ALZ trial terminated","url":"https://stock-news.laohu8.com/highlight/detail?id=2509523335","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2509523335?lang=en_us&edition=fundamental","pubTime":"2025-02-05 23:40","pubTimestamp":1738770032,"startTime":"0","endTime":"0","summary":"Cassava Sciences (SAVA)’ trial for simufilam 50 mg or 100 mg for mild-to-moderate Alzheimer’s disease, named “REFOCUS-ALZ,” has been “terminated” i...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/clinical-trials-site-shows-cassava-sciences-refocus-alz-trial-terminated?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/clinical-trials-site-shows-cassava-sciences-refocus-alz-trial-terminated?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4007","BK4547","BK4588","BK4585","SAVA"],"gpt_icon":0},{"id":"2501747302","title":"Cassava Sciences to Reduce Staff, Halt Further Analysis","url":"https://stock-news.laohu8.com/highlight/detail?id=2501747302","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501747302?lang=en_us&edition=fundamental","pubTime":"2025-01-08 19:09","pubTimestamp":1736334591,"startTime":"0","endTime":"0","summary":"Cassava Sciences  said late Tuesday that it is reducing its workforce by ten employees, laying off 33% of its workforce in Q1, incurring one-time expenses of $400,000 for the reduction.The clinical-stage company said it will reduce expenses by halting the planned biomarker analysis of additional plasma samples from previous mid-stage studies of its investigational potential treatments for central nervous system diseases including Alzheimer's disease.The measures come after the company said a late-stage study of its drug simufilam as a potential treatment for Alzheimer's patients did not meet its endpoints.","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4588","BK4007","BK4547","BK4585","SAVA"],"gpt_icon":1},{"id":"2501759217","title":"BRIEF-Cassava Sciences Provides A Business Update","url":"https://stock-news.laohu8.com/highlight/detail?id=2501759217","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501759217?lang=en_us&edition=fundamental","pubTime":"2025-01-08 06:49","pubTimestamp":1736290179,"startTime":"0","endTime":"0","summary":"BRIEF-Cassava Sciences Provides A Business UpdateJan 7 (Reuters) - Cassava Sciences Inc SAVA.O:CASSAVA SCIENCES PROVIDES A BUSINESS UPDATECASSAVA SCIENCES INC: IMPLEMENTING COST CURTAILMENT INCLUDING ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250107:nTUA4QCJDC:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","BK4547","SAVA","BK4588","BK4585"],"gpt_icon":0},{"id":"2501758928","title":"Cassava Sciences Inc: in Final Stages of Discontinuing Refocus-Alz Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2501758928","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501758928?lang=en_us&edition=fundamental","pubTime":"2025-01-08 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33%","url":"https://stock-news.laohu8.com/highlight/detail?id=2501589257","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501589257?lang=en_us&edition=fundamental","pubTime":"2025-01-08 05:30","pubTimestamp":1736285400,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250107:nTUA4QCJDC:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4585","BK4588","SAVA","BK4547","BK4007"],"gpt_icon":0},{"id":"2501475826","title":"Cassava Sciences Provides a Business 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Join Class Action Suit Seeking Recovery – Contact Levi & Korsinsky LLP","url":"https://stock-news.laohu8.com/highlight/detail?id=2491779357","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2491779357?lang=en_us&edition=fundamental","pubTime":"2024-12-13 05:50","pubTimestamp":1734040204,"startTime":"0","endTime":"0","summary":"THE LAWSUIT: A class action securities lawsuit was filed against Cassava Sciences, Inc. (SAVA) that seeks to recover losses of Cassava Sciences, In...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/class-action/lost-money-on-cassava-sciences-inc-sava-join-class-action-suit-seeking-recovery-contact-levi-korsinsky-llp?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/class-action/lost-money-on-cassava-sciences-inc-sava-join-class-action-suit-seeking-recovery-contact-levi-korsinsky-llp?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4547","BK4585","BK4588","SAVA","BK4007"],"gpt_icon":0},{"id":"2487592243","title":"Biotech Stock Roundup: BBIO Stock Up on Drug Approval, SAVA, APLT Plunge on Setbacks & More","url":"https://stock-news.laohu8.com/highlight/detail?id=2487592243","media":"Zacks","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2487592243?lang=en_us&edition=fundamental","pubTime":"2024-11-30 02:51","pubTimestamp":1732906260,"startTime":"0","endTime":"0","summary":"Pipeline and regulatory updates are in focus in the biotech sector. Among these, BridgeBio Pharma, Inc. BBIO gained on approval of cardiovascular drug while a few others faced setbacks.BridgeBio Pharma, Inc. announced that it has obtained FDA approval for its pipeline candidate acoramidis for the treatment of adults with transthyretin amyloidosis cardiomyopathy  to reduce cardiovascular death and cardiovascular-related hospitalization. The candidate has been approved under the brand name Attruby. BBIO stock surged on the news.The FDA approval is based on positive results from the phase III ATTRibute-CM study, in which Attruby significantly reduced death and cardiovascular-related hospitalization and improved quality of life. The approval came ahead of the targeted action date of Nov. 29.MariTide caused approximately 20% average weight loss over 52 weeks without reaching a weight loss plateau. In patients with type II diabetes who were obese or overweight, the weight loss reduction was ","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/0.VF5p.GUKhgU24gMni2XA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/59a827b8514d5d6d47690daa5eb16f24","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/0.VF5p.GUKhgU24gMni2XA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/59a827b8514d5d6d47690daa5eb16f24"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/biotech-stock-roundup-bbio-stock-185100614.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU2242646821.SGD","LU0320765992.SGD","LU0889565916.HKD","LU0109394709.USD","BK4599","LU2242652126.USD","LU1057294990.SGD","BK4534","LU0122379950.USD","LU2112291526.USD","BK4505","BK4566","BK4585","LU0058720904.USD","BK4007","BK4547","LU0289739699.SGD","IE00B2B36J28.USD","IE00BJJMRZ35.SGD","BK4533","BBIO","BK4588","LU1023059063.AUD","LU1983299246.USD","SAVAW","LU0868494617.USD","IE00B4R5TH58.HKD","IE0009355771.USD","APLT","SG9999001440.SGD","BK4139","IE00BFTCPJ56.SGD","IE0002141913.USD","IE00BJT1NW94.SGD","SAVA","LU1061106388.HKD","BK4581","LU1571399168.USD","AMGN"],"gpt_icon":1},{"id":"2486856869","title":"A Post-Mortem on Cassava Sciences","url":"https://stock-news.laohu8.com/highlight/detail?id=2486856869","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2486856869?lang=en_us&edition=fundamental","pubTime":"2024-11-27 05:36","pubTimestamp":1732656960,"startTime":"0","endTime":"0","summary":"There are few things in the investment world scarier than owning a biotech that misses the mark. That was the case this morning with once high-flying stock Cassava Sciences . This is a stock that once skyrocketed to $146. A little over three years later, this thing closed the day at $4.30, down 83% on the day.It’s Alzheimer’s drug Simufilam did not show a significant reduction in cognitive or functional decline versus placebo in patients with mild-to-moderate Alzheimer’s disease in its Phase 3 study. The good news, if there is any, is that Cassava still has $149 million in cash as of the end of last quarter. The bad news is, they’ve got a strikeout where they were hoping to hit a home run.Moving Averages: Bartosiak starts by examining the stock's moving averages, such as the 50-day and 200-day moving averages. He points out the significance of crossovers and divergences between these averages, which can indicate potential trend changes.To read this article on Zacks.com click here.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/post-mortem-cassava-sciences-213600264.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4585","SAVA","SAVAW","BK4547","BK4588","BK4212","BK4007","POST"],"gpt_icon":1},{"id":"2486835124","title":"SAVA Stock Plunges 84% on Alzheimer's Drug Failure in Late-Stage Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2486835124","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2486835124?lang=en_us&edition=fundamental","pubTime":"2024-11-27 02:42","pubTimestamp":1732646520,"startTime":"0","endTime":"0","summary":"Cassava Sciences’ SAVA stock shed more than 80% of market value on Monday after the company reported that its lead pipeline drug, simufilam, failed to meet the primary endpoints in a late study for Alzheimer’s disease .SAVA releases top-line results from the ReThink-ALZ study, which evaluated simufilam in patients with mild-to-moderate AD. Treatment with the drug failed to achieve a significant reduction in cognitive or functional decline in AD patients when compared to placebo over a 52-week period, as assessed by the ADAS-COG12 and ADCS-ADL scales. The study failed to meet any pre-specified secondary and exploratory biomarker endpoints.Based on the above study results, Cassava also decided to discontinue the phase III ReFocus-ALZ study, which evaluated simufilam in AD patients over a 76-week period. It will also be discontinuing the open-label extension study on the drug.In a related action, the SEC charged Dr. Hoau-Yan Wang, a consultant for Cassava and associate medical professor 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