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Sionna Therapeutics

36.06

-1.9550-5.14%

Volume:48.33K

Turnover:1.78M

Market Cap:1.61B

PE:-22.68

High:38.77

Open:38.05

Low:35.82

Close:38.02

52wk High:45.00

52wk Low:7.26

Shares:44.63M

Float Shares:12.61M

Volume Ratio:0.54

T/O Rate:0.38%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-1.5900

EPS(LYR):-15.9861

ROE:-28.07%

ROA:-19.45%

PB:5.00

PE(LYR):-2.26

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Overview Company News Filings

Analysts Offer Insights on Healthcare Companies: Sionna Therapeutics, Inc. (SION) and Incyte (INCY)

Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares

OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Inc. Common Shares

Sionna Therapeutics to Present at the Guggenheim Securities Emerging Outlook: Biotech Summit 2026

BTIG Remains a Buy on Sionna Therapeutics, Inc. (SION)

Major Stake Unloaded in Sionna Therapeutics Sparks Fresh Market Buzz

TPG GP A, LLC Reports Disposal of Sionna Therapeutics Inc. Common Shares

Sionna Therapeutics Price Target Maintained With a $58.00/Share by BTIG

Sionna Therapeutics Inc : Btig Raises Target Price to $58 From $50

THOMSON REUTERS

Sionna Therapeutics Is Maintained at Buy by BTIG

OrbiMed Advisors Reports Disposal of Sionna Therapeutics Inc. Common Shares

Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares

Sionna Therapeutics Initiated at Outperform by LifeSci Capital

LifeSci Capital Initiates Coverage on Sionna Therapeutics With Outperform Rating, $60 Price Target

MT Newswires Live

OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Common Shares

Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares

Chief Legal Officer Jennifer Fitzpatrick Reports Disposal of Sionna Therapeutics Inc. Common Shares

Sionna Therapeutics Valuation Topping $2 Billion Is 'Too Optimistic', RBC Says

MT Newswires Live

Sionna Therapeutics Shares Lower After RBC Downgrade

MT Newswires Live

Sionna Therapeutics Cut to Underperform From Sector Perform by RBC Capital

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Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on February 04, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260205:nNDL6GV70V:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SION"],"gpt_icon":0},{"id":"2609310886","title":"OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Inc. 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Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on February 04, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260205:nNDL7n3DY3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Inc. 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According to TipRanks, Y...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/btig-remains-a-buy-on-sionna-therapeutics-inc-sion-blurbs-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/btig-remains-a-buy-on-sionna-therapeutics-inc-sion-blurbs-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2606276307","title":"Major Stake Unloaded in Sionna Therapeutics Sparks Fresh Market Buzz","url":"https://stock-news.laohu8.com/highlight/detail?id=2606276307","media":"TIPRANKS","labels":["shareholding"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2606276307?lang=en_us&edition=fundamental","pubTime":"2026-01-27 10:03","pubTimestamp":1769479399,"startTime":"0","endTime":"0","summary":"New insider activity at Sionna Therapeutics, Inc. ( ($SION) ) has taken place on January 26, 2026. Significant shareholder TPG GP A, LLC has offloa...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/insider-trading/major-stake-unloaded-in-sionna-therapeutics-sparks-fresh-market-buzz-insider-trading?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/insider-trading/major-stake-unloaded-in-sionna-therapeutics-sparks-fresh-market-buzz-insider-trading?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"shareholding","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4139","SION"],"gpt_icon":0},{"id":"2606022149","title":"TPG GP A, LLC Reports Disposal of Sionna Therapeutics Inc. Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2606022149","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2606022149?lang=en_us&edition=fundamental","pubTime":"2026-01-27 06:25","pubTimestamp":1769466329,"startTime":"0","endTime":"0","summary":"TPG GP A, LLC, a 10% owner, has reported a disposal of common shares of Sionna Therapeutics Inc. The filing was submitted by more than one reporting person, including Gerald Neugebauer  and other reporting beneficial owners. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on January 26, 2026, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260126:nNDL60Mwww:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":"TPG GP A, LLC Reports Disposal of Sionna Therapeutics Inc. Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2603694137","title":"Sionna Therapeutics Price Target Maintained With a $58.00/Share by BTIG","url":"https://stock-news.laohu8.com/highlight/detail?id=2603694137","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2603694137?lang=en_us&edition=fundamental","pubTime":"2026-01-14 18:12","pubTimestamp":1768385520,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SION/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  January 14, 2026 05:12 ET (10:12 GMT)","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION"],"gpt_icon":0},{"id":"2601870101","title":"Sionna Therapeutics Inc : Btig Raises Target Price to $58 From $50","url":"https://stock-news.laohu8.com/highlight/detail?id=2601870101","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2601870101?lang=en_us&edition=fundamental","pubTime":"2026-01-07 20:12","pubTimestamp":1767787926,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260107:nFWN3Y80YF:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2601210877","title":"Sionna Therapeutics Is Maintained at Buy by BTIG","url":"https://stock-news.laohu8.com/highlight/detail?id=2601210877","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2601210877?lang=en_us&edition=fundamental","pubTime":"2026-01-07 19:56","pubTimestamp":1767786960,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SION/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  January 07, 2026 06:56 ET (11:56 GMT)","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION"],"gpt_icon":0},{"id":"2595752231","title":"OrbiMed Advisors Reports Disposal of Sionna Therapeutics Inc. Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2595752231","media":"Reuters","labels":["insiderTrades"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2595752231?lang=en_us&edition=fundamental","pubTime":"2025-12-30 09:44","pubTimestamp":1767059079,"startTime":"0","endTime":"0","summary":"OrbiMed Advisors LLC has reported a disposal of common shares of Sionna Therapeutics Inc. , according to a recent SEC filing. The transaction was jointly filed by OrbiMed Advisors LLC and other reporting beneficial owners. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 29, 2025, and is solely responsible for the information contained therein.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251230:nNDL2KFP76:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"insiderTrades","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","SION"],"gpt_icon":0},{"id":"2595524607","title":"Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2595524607","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2595524607?lang=en_us&edition=fundamental","pubTime":"2025-12-30 09:42","pubTimestamp":1767058963,"startTime":"0","endTime":"0","summary":"Peter A. Thompson, Director of Sionna Therapeutics Inc., has reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 29, 2025, and is solely responsible for the information contained therein.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251230:nNDL6yyWDZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2593411902","title":"Sionna Therapeutics Initiated at Outperform by LifeSci Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2593411902","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2593411902?lang=en_us&edition=fundamental","pubTime":"2025-12-24 00:17","pubTimestamp":1766506620,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SION/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 23, 2025 11:17 ET (16:17 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION"],"gpt_icon":0},{"id":"2593413578","title":"LifeSci Capital Initiates Coverage on Sionna Therapeutics With Outperform Rating, $60 Price Target","url":"https://stock-news.laohu8.com/highlight/detail?id=2593413578","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2593413578?lang=en_us&edition=fundamental","pubTime":"2025-12-23 21:53","pubTimestamp":1766497992,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics, Inc. (SION) has an average rating of overweight and mean price target of $42.57, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic resear","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SION"],"gpt_icon":0},{"id":"2592115254","title":"OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2592115254","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592115254?lang=en_us&edition=fundamental","pubTime":"2025-12-20 08:29","pubTimestamp":1766190594,"startTime":"0","endTime":"0","summary":"OrbiMed Advisors LLC reported a disposal of common shares of Sionna Therapeutics Inc. , according to a recent SEC Form 4 filing. The form was filed by multiple reporting persons, including OrbiMed Advisors LLC and other reporting beneficial owners. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 19, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251220:nNDL42b98f:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":"OrbiMed Advisors LLC Reports Sale of Sionna Therapeutics Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2592115233","title":"Director Peter A. Thompson Reports Disposal of Sionna Therapeutics Inc. Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2592115233","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2592115233?lang=en_us&edition=fundamental","pubTime":"2025-12-20 08:25","pubTimestamp":1766190331,"startTime":"0","endTime":"0","summary":"Peter A. Thompson, a Director of Sionna Therapeutics Inc., has reported a disposal of common shares of the company. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 19, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251220:nNDL9xvb4q:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2590532280","title":"Chief Legal Officer Jennifer Fitzpatrick Reports Disposal of Sionna Therapeutics Inc. Common Shares","url":"https://stock-news.laohu8.com/highlight/detail?id=2590532280","media":"Reuters","labels":["shareholding","insiderTrades","express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2590532280?lang=en_us&edition=fundamental","pubTime":"2025-12-10 05:57","pubTimestamp":1765317449,"startTime":"0","endTime":"0","summary":"Jennifer Fitzpatrick, Chief Legal Officer of Sionna Therapeutics Inc., has reported a disposal of common shares of Sionna Therapeutics Inc. The full filing can be accessed through the link below.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Sionna Therapeutics Inc. published the original content used to generate this news brief via EDGAR, the Electronic Data Gathering, Analysis, and Retrieval system operated by the U.S. Securities and Exchange Commission , on December 09, 2025, and is solely responsible for the information contained therein.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20251209:nNDL7T1rjs:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":"Chief Legal Officer Jennifer Fitzpatrick Reports Disposal of Sionna Therapeutics Inc. Common Shares","news_tag":"shareholding,insiderTrades,express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION","BK4139"],"gpt_icon":0},{"id":"2589183618","title":"Sionna Therapeutics Valuation Topping $2 Billion Is 'Too Optimistic', RBC Says","url":"https://stock-news.laohu8.com/highlight/detail?id=2589183618","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2589183618?lang=en_us&edition=fundamental","pubTime":"2025-12-05 00:45","pubTimestamp":1764866728,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics'  valuation topping $2 billion is \"too optimistic\" as the company's early-stage cystic fibrosis program faces significant hurdles before proving itself in clinical trials, RBC Capital Markets said Thursday in a report.Interest in Sionna has been fueled by hopes of major upside and the stock's perceived connection to widely held Vertex Pharmaceuticals , and investor feedback to RBC's downgrade of Sionna on Monday to underperform from sector perform triggered \"significant feedback,\" according to the report.Sionna is developing small-molecule drugs designed to work alongside Vertex's widely used therapy Trikafta, aiming to improve outcomes for cystic fibrosis patients, the report said.RBC cited variability in Sionna's human bronchial epithelial assays, where Trikafta's performance appeared weaker than in Vertex's published studies, raising questions about the reliability of Sionna's comparisons and the likelihood of clinical benefit.Despite investor pushback, RBC maint","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["VERX","LU2462157665.USD","BK4533","LU2236285917.USD","LU2362541513.USD","LU2456880835.USD","BK4585","BK4023","LU0289739699.SGD","LU0109394709.USD","LU0889565916.HKD","SGXZ57979304.SGD","LU0417517546.SGD","LU1093756168.USD","LU1093756325.SGD","LU0757428866.USD","LU2362541273.HKD","IE00B19Z9Z06.USD","IE00BJT1NW94.SGD","IE00BJJMRZ35.SGD","LU1430594728.SGD","IE00B894F039.SGD","BK4532","IE00B19Z9P08.USD","IE00BFTCPJ56.SGD","LU2362540622.SGD","SG9999001176.USD","SG9999013999.USD","VRTX","IE00B19Z3581.USD","LU0320765992.SGD","IE0002141913.USD","LU0256863811.USD","LU2417539215.USD","BK4567","LU0823416689.USD","LU0234570918.USD","IE0009355771.USD","SG9999001176.SGD","SION","IE0002270589.USD","LU1674673691.USD","LU1069344957.HKD","LU2324357040.USD","LU1778281490.HKD","LU1585245621.USD","IE00B4R5TH58.HKD","LU1815336091.USD","BK4139","IE00B19Z3B42.SGD"],"gpt_icon":0},{"id":"2588770472","title":"Sionna Therapeutics Shares Lower After RBC Downgrade","url":"https://stock-news.laohu8.com/highlight/detail?id=2588770472","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588770472?lang=en_us&edition=fundamental","pubTime":"2025-12-02 04:03","pubTimestamp":1764619389,"startTime":"0","endTime":"0","summary":"Sionna Therapeutics  shares fell nearly 14% in recent Monday trading after RBC Capital Markets downgraded the stock to underperform from sector perform, while keeping its $24 price target.Trading volume stood at over 526,000, versus the daily average of about 300,000.Price: 37.53, Change: -6.04, Percent Change: -13.86","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SION"],"gpt_icon":0},{"id":"2588977511","title":"Sionna Therapeutics Cut to Underperform From Sector Perform by RBC Capital","url":"https://stock-news.laohu8.com/highlight/detail?id=2588977511","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2588977511?lang=en_us&edition=fundamental","pubTime":"2025-12-01 22:37","pubTimestamp":1764599820,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/SION/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  December 01, 2025 09:37 ET (14:37 GMT)","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["SION"],"gpt_icon":0}],"pageSize":20,"totalPage":4,"pageCount":1,"totalSize":76,"code":"91000000","status":"200"}]}}