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First-in-class examples of direct SHOC2 binders and modulators of SMP complex assembly identified with potential to block oncogenic RAS/MAPK pathway signaling. Poster Presentation Highlights Abstract 390 – ERAS-0015 is a pan-RAS molecular glue with best-in-class potential in RAS mutant solid tumors. ERAS-0015 demonstrated favorable pharmacokinetic properties including longer residence time and greater tissue exposure that led to robust anti-tumor activity alone and in combination at doses lower than the leading pan-RAS molecular glue in development. ERAS-0015 is a pan-RAS molecular glue designed to shut down pathogenic signaling mediated by mutant and wildtype RAS by targeting RAS in the GTP-bound state.8-21-fold greater cyclophilin A  binding for ERAS-0015 vs. pan-RAS molecular glue comparator RMC-6236. ERAS-0015 dose-dependently formed a ternary complex with active state RAS and CypA, wh","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/erasca-presents-preclinical-data-reinforcing-200500174.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","BK4135","ERAS","IE00BHPRN162.USD","WT","BK4539"],"gpt_icon":0},{"id":"2526482948","title":"Erasca Slides As Insider Purchases Lose Another US$84k","url":"https://stock-news.laohu8.com/highlight/detail?id=2526482948","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2526482948?lang=en_us&edition=fundamental","pubTime":"2025-04-09 00:01","pubTimestamp":1744128088,"startTime":"0","endTime":"0","summary":"Insiders who bought US$181.9k worth of Erasca, Inc.'s  stock at an average buy price of US$2.27 over the last year may be disappointed by the recent 11% decrease in the stock. This is not good as insiders invest based on expectations that their money will appreciate over time. However, as a result of recent losses, their original investment is now worth only US$98.0k.While we would never suggest that investors should base their decisions solely on what the directors of a company have been doing, we would consider it foolish to ignore insider transactions altogether.Trump has pledged to \"unleash\" American oil and gas and these 15 US stocks have developments that are poised to benefit.The fact that there have been no Erasca insider transactions recently certainly doesn't bother us. On a brighter note, the transactions over the last year are encouraging. Insiders own shares in Erasca and we see no evidence to suggest they are worried about the future. 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